Baidu
map

Alzheimers Dementia:复旦华山医院:教育水平和居住环境,对认知影响颇大

2022-06-05 Freeman MedSci原创 发表于威斯康星

教育程度和居住环境对老年人认知能力下降的叠加效应。教育对于在弱势环境下保持认知健康尤为重要。

越来越多的证据表明,阿尔茨海默病(AD)和其他类型的痴呆症已成为全球健康的沉重负担和主要挑战。由于缺乏有效的晚年痴呆症的疾病修饰治疗,寻求潜在的可修改的风险因素是非常重要的。


图1: 论文封面图


教育的效果可能是由认知储备的改善和更有效地利用大脑网络或认知范式驱动的。以前的研究表明,邻里环境(NE)在多种健康结果中起着重要作用,特别是在晚年认知方面。这些现有的证据意味着,丰富的环境在认知刺激方面提供了一个优势,这与增加认知储备和减弱大脑病理的负担有关。

重要的是,教育与NE有复杂的相互作用。以前的研究中,通过比较两个相隔20年的社区队列的数据,复旦大学的崔梅等人,观察到痴呆症的患病率和发病率呈上升趋势,特别是在受教育年限≤6年的个体中。

然而,他们没有考虑到由于社会经济地位(SES)和社会及物质资源的改善,NE随时间变化的影响。

泰州影像研究(TIS)和上海老龄化研究(SAS)是在中国东南地区进行的两个独立的社区队列研究,其研究设计和程序相似,但研究地点分别在农村和城市地区。

因此,这两个队列研究提供了一个独特而有价值的来源,以研究教育程度对认知能力下降的影响在弱势人群(TIS)和先进的NEs(SAS)中是否有差异。

藉此,复旦大学的崔梅等人,利用泰州影像研究(TIS)和上海老龄化研究(SAS)的1286名参与者的数据,调查并比较了教育程度和认知能力下降之间的关系。

 

图2:论文结果图

他们发现:与低学历的参与者相比,在泰州影像研究中,高学历的参与者在全局认知(每年0.062分,P<0.001)、记忆(每年0.054分,P<0.05)和注意力(每年0.065分,P<0.01)方面表现出明显的缓慢下降。

而在上海老年研究中,高学历的人仅在注意力方面表现出缓慢的下降(每年0.028Z分,P<0.05)。

该研究的重要意义在于发现了: 教育程度和居住环境对老年人认知能力下降的叠加效应。教育对于在弱势环境下保持认知健康尤为重要。

原文出处:

Wang, Y., Jiang, Y., Wu, W., Xu, K., Zhao, Q., Tan, Z., Liang, X., Fan, M., Xiao, Z., Zheng, L., Ding, S., Dong, Q., Hong, Z., Jin, L., Chen, X., Ding, D., & Cui, M. (n.d.). _Education, neighborhood environment, and cognitive decline: Findings from two prospective cohort studies of older adults in China_.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1878526, encodeId=238818e8526be, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Mon Mar 27 17:21:33 CST 2023, time=2023-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779848, encodeId=aba91e7984821, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Thu Sep 01 09:21:33 CST 2022, time=2022-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718159, encodeId=22251e181597a, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Fri Nov 25 21:21:33 CST 2022, time=2022-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338566, encodeId=fc31133856672, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Mon Jun 06 04:21:33 CST 2022, time=2022-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538645, encodeId=369f1538645f7, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Mon Jun 06 04:21:33 CST 2022, time=2022-06-06, status=1, ipAttribution=)]
    2023-03-27 anminleiryan
  2. [GetPortalCommentsPageByObjectIdResponse(id=1878526, encodeId=238818e8526be, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Mon Mar 27 17:21:33 CST 2023, time=2023-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779848, encodeId=aba91e7984821, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Thu Sep 01 09:21:33 CST 2022, time=2022-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718159, encodeId=22251e181597a, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Fri Nov 25 21:21:33 CST 2022, time=2022-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338566, encodeId=fc31133856672, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Mon Jun 06 04:21:33 CST 2022, time=2022-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538645, encodeId=369f1538645f7, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Mon Jun 06 04:21:33 CST 2022, time=2022-06-06, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1878526, encodeId=238818e8526be, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Mon Mar 27 17:21:33 CST 2023, time=2023-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779848, encodeId=aba91e7984821, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Thu Sep 01 09:21:33 CST 2022, time=2022-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718159, encodeId=22251e181597a, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Fri Nov 25 21:21:33 CST 2022, time=2022-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338566, encodeId=fc31133856672, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Mon Jun 06 04:21:33 CST 2022, time=2022-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538645, encodeId=369f1538645f7, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Mon Jun 06 04:21:33 CST 2022, time=2022-06-06, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1878526, encodeId=238818e8526be, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Mon Mar 27 17:21:33 CST 2023, time=2023-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779848, encodeId=aba91e7984821, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Thu Sep 01 09:21:33 CST 2022, time=2022-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718159, encodeId=22251e181597a, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Fri Nov 25 21:21:33 CST 2022, time=2022-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338566, encodeId=fc31133856672, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Mon Jun 06 04:21:33 CST 2022, time=2022-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538645, encodeId=369f1538645f7, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Mon Jun 06 04:21:33 CST 2022, time=2022-06-06, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1878526, encodeId=238818e8526be, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Mon Mar 27 17:21:33 CST 2023, time=2023-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779848, encodeId=aba91e7984821, content=<a href='/topic/show?id=51b4238909' target=_blank style='color:#2F92EE;'>#alzheimers#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2389, encryptionId=51b4238909, topicName=alzheimers)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Thu Sep 01 09:21:33 CST 2022, time=2022-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718159, encodeId=22251e181597a, content=<a href='/topic/show?id=8f0658433a' target=_blank style='color:#2F92EE;'>#dementia#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5843, encryptionId=8f0658433a, topicName=dementia)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307e32501717, createdName=linlin2323, createdTime=Fri Nov 25 21:21:33 CST 2022, time=2022-11-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1338566, encodeId=fc31133856672, content=<a href='/topic/show?id=767711566a9' target=_blank style='color:#2F92EE;'>#MERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11566, encryptionId=767711566a9, topicName=MERS)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Mon Jun 06 04:21:33 CST 2022, time=2022-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538645, encodeId=369f1538645f7, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Mon Jun 06 04:21:33 CST 2022, time=2022-06-06, status=1, ipAttribution=)]
    2022-06-06 saikp

拓展阅读

IJNS:多成分运动干预对轻度认知障碍患者认知功能的影响

结果表明,多成分运动干预对轻度认知障碍的各认知领域都有积极影响,包括整体认知、认知灵活性、处理速度、语言流畅性、注意力和记忆力。

【今日分享】德国神经病学学会关于帕金森病患者认知障碍和情感障碍的诊断和治疗指南:诊断程序和非药物干预的新亮点

认知障碍和痴呆以及情感障碍是帕金森病 (PwPD) 患者中常见的致残综合征。作者总结了德国神经学会 (DGN) 2023 年更新的德国“帕金森病”指南的建议,重点关注这些疾病的

Phytomedicine:交泰丸及其有效组分黄连碱通过JAK2/STAT3信号通路减轻db/db小鼠认知功能障碍

探讨交泰丸(JTW)抗糖尿病(DM)和认知障碍(CI)的作用机制,筛选JTW的有效成分。

J Ethnopharmacol:固本健脑液可缓解与PI3K/AKT/mTOR信号通路激活有关的APP/PS1小鼠昼夜节律和睡眠节律紊乱

通过转录组测序和实验验证,探讨固本健脑液(GBJNY)在阿尔茨海默病昼夜节律睡眠觉醒障碍和认知功能障碍中的调节作用及其可能机制。

【论著】异钩藤碱对急性脑梗死大鼠认知障碍的影响及机制研究

本实验拟通过构建急性脑梗死大鼠模型,探究异钩藤碱对急性脑梗死大鼠认知障碍的影响以及相应的机制。

Mol Psychiatry:难治性首发精神病患者的神经认知和 NMDAR 共激动剂通路

这项研究为理解治疗抵抗型首次发病精神病患者的认知缺陷提供了新的视角,并揭示了NMDAR共激动剂通路在这些缺陷中的作用。

认知障碍老年人口腔健康管理的最佳证据总结

复旦大学护理学院 · 2023-12-25

故事疗法延缓轻中度认知障碍老年人认知衰退的最佳证据总结

南京理工大学循证社会科学与健康研究中心 · 2022-12-25

认知障碍患者住院期间走失风险管理的最佳证据总结

郑州大学第一附属医院神经内科 · 2022-11-15

新型冠状病毒肺炎后认知障碍诊治和管理共识

中国医师协会神经内科分会认知障碍专业委员会专家组 · 2022-08-19

2022 NHS 临床指南:Covid-19 和认知障碍 (839)

NHS 大格拉斯哥和克莱德 (NHSGGC) · 2022-07-06

Baidu
map
Baidu
map
Baidu
map