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Arch Gynecol Obstet:CRP预测宫颈功能不全患者的羊膜腔内感染

2015-03-18 MedSci MedSci原创

摘要目的:确定如何利用非侵入性方法,预测宫颈功能不全或无症状短子宫颈( ≤15毫米)女性的羊膜腔内感染或炎症(IAI)发生。方法:这项回顾性队列研究包括了共72例无症状宫颈功能不全(54例 )和无症状的宫颈短(18例 )的妇女,时间为其孕17-28周。收集并测定母血的C-反应蛋白(CPR)和白细胞计数,并在羊膜腔穿刺后超声测量宫颈长度。另外进行羊水(AF )培养,测定羊水内的白细胞介素-6(IL-

目的:
确定如何利用非侵入性方法,预测宫颈功能不全或无症状短子宫颈( ≤15毫米)女性的羊膜腔内感染或炎症(IAI)发生。

方法:
这项回顾性队列研究包括了共72例无症状宫颈功能不全(54例 )和无症状的宫颈短(18例 )的妇女,时间为其孕17-28周。收集并测定母血的C-反应蛋白(CPR)和白细胞计数,并在羊膜腔穿刺后超声测量宫颈长度。另外进行羊水(AF )培养,测定羊水内的白细胞介素-6(IL- 6)水平和白细胞计数。

结果:
羊膜腔内炎症和羊水培养阳性的发生率分别为22.2% (16/72)和8.3%(6/72)。预测羊膜腔内感染的羊水白细胞介素-6的最佳临界值为≥7.6 ng/mL,这被用于诊断羊膜腔内炎症的发生。无关培养结果,羊膜腔发炎的女性相比无感染女性发生早产和妊娠结局不良的机率将增加。在多变量回归分析中,CRP是与IAI显著相关的唯一非侵入性变量。此外,根据该曲线,CRP和羊水的白细胞计数没有统计学意义。

结论:

对于宫颈功能不全或短宫颈的女性,羊膜腔内感染的风险预测可以通过非侵入性方法——测量母体血清C-反应蛋白水平。总体而言,这种非侵入性的参数与白细胞计数在预测羊膜腔内感染时具有相似的精准性 。

原始出处:


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    2015-05-28 yhy100200
  2. [GetPortalCommentsPageByObjectIdResponse(id=2011183, encodeId=0723201118371, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Thu May 28 10:06:00 CST 2015, time=2015-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2043845, encodeId=a6fd204384540, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sun May 03 20:06:00 CST 2015, time=2015-05-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19223, encodeId=afd71922350, content=女性,羊膜腔内感染的, beContent=null, objectType=article, channel=null, level=null, likeNumber=143, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20150920/IMG55FDE671A89482379.jpg, createdBy=cef3108336, createdName=x35042875, createdTime=Tue Mar 31 23:29:00 CST 2015, time=2015-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269576, encodeId=314f12695e64d, content=<a href='/topic/show?id=ca6952e52f' target=_blank style='color:#2F92EE;'>#CRP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5275, encryptionId=ca6952e52f, topicName=CRP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1cc90, createdName=rebeccajiejie, createdTime=Fri Mar 20 11:06:00 CST 2015, time=2015-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407948, encodeId=1772140e948af, content=<a href='/topic/show?id=92194628826' target=_blank style='color:#2F92EE;'>#宫颈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46288, encryptionId=92194628826, topicName=宫颈)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11102737131, createdName=一闲, createdTime=Fri Mar 20 11:06:00 CST 2015, time=2015-03-20, status=1, ipAttribution=)]
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    2015-03-31 x35042875

    女性,羊膜腔内感染的

    0

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    2015-03-20 rebeccajiejie
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    2015-03-20 一闲
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