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J Indian Soc Periodontol:牙周组织中存在高危人乳头瘤病毒

2018-03-04 MedSci MedSci原创

人类乳头状瘤病毒(HPV)是已经在牙周袋和牙龈沟中鉴定的小型DNA病毒。高风险的HPV也与头颈部癌的发生有关。研究认为,牙周组织可能是HPV的藏身之地。 本研究旨在检测牙周袋中、健康人龈沟以及局部慢性牙周炎患者牙龈中人乳头状瘤病毒(HPV)的存在;定量评估HPV3受试者中E6和E7 mRNA的水平。评估牙周袋是否是HPV的藏身之所。 本病例对照研究包括30例局部慢性牙周炎(病例组)和30例牙周健康

人类乳头状瘤病毒(HPV)是已经在牙周袋和牙龈沟中鉴定的小型DNA病毒。高风险的HPV也与头颈部癌的发生有关。研究认为,牙周组织可能是HPV的藏身之地。

本研究旨在检测牙周袋中、健康人龈沟以及局部慢性牙周炎患者牙龈中人乳头状瘤病毒(HPV)的存在;定量评估HPV3受试者中E6和E7 mRNA的水平。评估牙周袋是否是HPV的藏身之所。

本病例对照研究包括30例局部慢性牙周炎(病例组)和30例牙周健康受试者(对照组)。病例组中取两个样本,一个来自牙周袋,另一个来自龈沟,对照组取一个样本。

病例和对照组样本分别以刮牙周袋内壁和纸尖提取牙龈沟的形式收集。使用原位杂交和流式细胞术鉴定和估计HPV的E6/E7 mRNA。统计分析使用平均值,百分比和卡方检验进行。统计软件包SPSS版本13.0来分析数据。P值<0.05被认为是统计学显著性。

结果显示,牙周袋和龈沟液中含有HPV E6/E7 mRNA。

该研究结果表明,牙周组织中存在HPV E6/E7 mRNA,支持了牙周组织作为潜伏HPV的藏身之所的假设,并且口腔癌、牙周炎和HPV之间可能存在协同作用。然而,仍需前瞻性研究进一步探索。

原始出处:


Shipilova A, Dayakar MM, Gupta D. High risk human papillomavirus in the periodontium : A case control study. J Indian Soc Periodontol. 2017 Sep-Oct;21(5):380-385. doi: 10.4103/jisp.jisp_56_17.

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    2018-12-04 feather89
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    2018-03-06 liuyong2982
  6. [GetPortalCommentsPageByObjectIdResponse(id=1969712, encodeId=41881969e1215, content=<a href='/topic/show?id=641e6e5300d' target=_blank style='color:#2F92EE;'>#牙周组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67530, encryptionId=641e6e5300d, topicName=牙周组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58df296, createdName=shock_melon, createdTime=Wed Sep 19 15:28:00 CST 2018, time=2018-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727119, encodeId=4d1a1e2711959, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Dec 04 03:28:00 CST 2018, time=2018-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638465, encodeId=8dda1638465f3, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Sep 25 13:28:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443485, encodeId=29b114434851f, content=<a href='/topic/show?id=4a65246327c' target=_blank style='color:#2F92EE;'>#人乳头瘤病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24632, encryptionId=4a65246327c, topicName=人乳头瘤病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fb15077773, createdName=ms3297076796458174, createdTime=Tue Mar 06 04:28:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450805, encodeId=6874145080519, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Mar 06 04:28:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469106, encodeId=fd5b1469106f9, content=<a href='/topic/show?id=211f98250b' target=_blank style='color:#2F92EE;'>#IND#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9825, encryptionId=211f98250b, topicName=IND)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16377007930, createdName=xiaogang319, createdTime=Tue Mar 06 04:28:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292953, encodeId=ea22292953d1, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba101609906, createdName=happsf, createdTime=Sun Mar 04 15:31:24 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292943, encodeId=93c2292943e7, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Mar 04 14:24:26 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292933, encodeId=74b9292933bf, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sun Mar 04 13:32:22 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-03-06 xiaogang319
  7. [GetPortalCommentsPageByObjectIdResponse(id=1969712, encodeId=41881969e1215, content=<a href='/topic/show?id=641e6e5300d' target=_blank style='color:#2F92EE;'>#牙周组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67530, encryptionId=641e6e5300d, topicName=牙周组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58df296, createdName=shock_melon, createdTime=Wed Sep 19 15:28:00 CST 2018, time=2018-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727119, encodeId=4d1a1e2711959, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Dec 04 03:28:00 CST 2018, time=2018-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638465, encodeId=8dda1638465f3, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Sep 25 13:28:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443485, encodeId=29b114434851f, content=<a href='/topic/show?id=4a65246327c' target=_blank style='color:#2F92EE;'>#人乳头瘤病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24632, encryptionId=4a65246327c, topicName=人乳头瘤病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fb15077773, createdName=ms3297076796458174, createdTime=Tue Mar 06 04:28:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450805, encodeId=6874145080519, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Mar 06 04:28:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469106, encodeId=fd5b1469106f9, content=<a href='/topic/show?id=211f98250b' target=_blank style='color:#2F92EE;'>#IND#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9825, encryptionId=211f98250b, topicName=IND)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16377007930, createdName=xiaogang319, createdTime=Tue Mar 06 04:28:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292953, encodeId=ea22292953d1, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba101609906, createdName=happsf, createdTime=Sun Mar 04 15:31:24 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292943, encodeId=93c2292943e7, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Mar 04 14:24:26 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292933, encodeId=74b9292933bf, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sun Mar 04 13:32:22 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-03-04 happsf

    学习

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1969712, encodeId=41881969e1215, content=<a href='/topic/show?id=641e6e5300d' target=_blank style='color:#2F92EE;'>#牙周组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67530, encryptionId=641e6e5300d, topicName=牙周组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58df296, createdName=shock_melon, createdTime=Wed Sep 19 15:28:00 CST 2018, time=2018-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727119, encodeId=4d1a1e2711959, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Dec 04 03:28:00 CST 2018, time=2018-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638465, encodeId=8dda1638465f3, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Sep 25 13:28:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443485, encodeId=29b114434851f, content=<a href='/topic/show?id=4a65246327c' target=_blank style='color:#2F92EE;'>#人乳头瘤病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24632, encryptionId=4a65246327c, topicName=人乳头瘤病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fb15077773, createdName=ms3297076796458174, createdTime=Tue Mar 06 04:28:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450805, encodeId=6874145080519, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Mar 06 04:28:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469106, encodeId=fd5b1469106f9, content=<a href='/topic/show?id=211f98250b' target=_blank style='color:#2F92EE;'>#IND#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9825, encryptionId=211f98250b, topicName=IND)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16377007930, createdName=xiaogang319, createdTime=Tue Mar 06 04:28:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292953, encodeId=ea22292953d1, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba101609906, createdName=happsf, createdTime=Sun Mar 04 15:31:24 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292943, encodeId=93c2292943e7, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Mar 04 14:24:26 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292933, encodeId=74b9292933bf, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sun Mar 04 13:32:22 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-03-04 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1969712, encodeId=41881969e1215, content=<a href='/topic/show?id=641e6e5300d' target=_blank style='color:#2F92EE;'>#牙周组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67530, encryptionId=641e6e5300d, topicName=牙周组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58df296, createdName=shock_melon, createdTime=Wed Sep 19 15:28:00 CST 2018, time=2018-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727119, encodeId=4d1a1e2711959, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Tue Dec 04 03:28:00 CST 2018, time=2018-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638465, encodeId=8dda1638465f3, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Tue Sep 25 13:28:00 CST 2018, time=2018-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443485, encodeId=29b114434851f, content=<a href='/topic/show?id=4a65246327c' target=_blank style='color:#2F92EE;'>#人乳头瘤病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24632, encryptionId=4a65246327c, topicName=人乳头瘤病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fb15077773, createdName=ms3297076796458174, createdTime=Tue Mar 06 04:28:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1450805, encodeId=6874145080519, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Mar 06 04:28:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469106, encodeId=fd5b1469106f9, content=<a href='/topic/show?id=211f98250b' target=_blank style='color:#2F92EE;'>#IND#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9825, encryptionId=211f98250b, topicName=IND)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16377007930, createdName=xiaogang319, createdTime=Tue Mar 06 04:28:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292953, encodeId=ea22292953d1, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ba101609906, createdName=happsf, createdTime=Sun Mar 04 15:31:24 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292943, encodeId=93c2292943e7, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Mar 04 14:24:26 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=292933, encodeId=74b9292933bf, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Sun Mar 04 13:32:22 CST 2018, time=2018-03-04, status=1, ipAttribution=)]
    2018-03-04 sunfeifeiyang

    0

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