Baidu
map

Stroke:存在脑小血管疾病的急性脑出血患者,预后不良

2016-05-24 MedSci MedSci原创

背景:脑小血管病(SVD)相关的结构变化包括白质病变(WML),腔隙性脑梗死和脑萎缩,对急性脑出血的预后的影响尚不清楚。研究者在急性脑出血后强化降压的大型试验(INTERACT2试验),就早期强化降压治疗的不同作用,确定的脑SVD的CT表现和预后的相关性。方法:3个独立的神经科临床医师,根据基线脑CT(脑出血内6小时)评估WML分级(van Swieten量表),腔隙性梗死卒中和脑萎缩(2线性测量

背景:脑小血管病(SVD)相关的结构变化包括白质病变(WML),腔隙性脑梗死和脑萎缩,对急性脑出血的预后的影响尚不清楚。研究者在急性脑出血后强化降压的大型试验(INTERACT2试验),就早期强化降压治疗的不同作用,确定的脑SVD的CT表现和预后的相关性。

方法:3个独立的神经科临床医师,根据基线脑CT(脑出血内6小时)评估WML分级(van Swieten量表),腔隙性梗死卒中和脑萎缩(2线性测量和视觉等级)。

结果:WML分级和脑萎缩2线性测量与90天死亡或重大残疾相关:WML(3级和4级VS 0级),额比率及第三脑室外侧裂的距离(最严重脑萎缩四分位数 VS 最轻四分位数)的多变量校正OR值分别为:1.42(95%CI,1.02-1.98)、1.47(1.08-1.99)和1.64(1.21-2.22)。腔隙性梗死和急性脑出血患者预后没有任何相关性。在强化降压治疗组和其他亚组脑SVD没有显著差异。

结论:已有脑SVD表现即WML和脑萎缩预测急性脑出血不良预后差。根据INTERACT2协议强化降低血压,患有脑SVD的患者没有明显危险。

原始出处:

Sato S, Delcourt C, et al. Significance of Cerebral Small-Vessel Disease in Acute Intracerebral Hemorrhage. Stroke. 2016 Mar.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1774644, encodeId=bfb81e7464432, content=<a href='/topic/show?id=d0e24e171d1' target=_blank style='color:#2F92EE;'>#小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47171, encryptionId=d0e24e171d1, topicName=小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c7a38663370, createdName=kord1995, createdTime=Mon Apr 17 05:59:00 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148214, encodeId=1c501482141b, content=赞了,认真探究、学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Oct 14 14:12:50 CST 2016, time=2016-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480853, encodeId=771814808534c, content=<a href='/topic/show?id=de508482e61' target=_blank style='color:#2F92EE;'>#脑小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84827, encryptionId=de508482e61, topicName=脑小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76c57719730, createdName=thinkibmz_44722596, createdTime=Thu May 26 11:59:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488327, encodeId=0914148832e5e, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Thu May 26 11:59:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497996, encodeId=4bf3149e9964d, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu May 26 11:59:00 CST 2016, time=2016-05-26, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1774644, encodeId=bfb81e7464432, content=<a href='/topic/show?id=d0e24e171d1' target=_blank style='color:#2F92EE;'>#小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47171, encryptionId=d0e24e171d1, topicName=小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c7a38663370, createdName=kord1995, createdTime=Mon Apr 17 05:59:00 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148214, encodeId=1c501482141b, content=赞了,认真探究、学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Oct 14 14:12:50 CST 2016, time=2016-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480853, encodeId=771814808534c, content=<a href='/topic/show?id=de508482e61' target=_blank style='color:#2F92EE;'>#脑小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84827, encryptionId=de508482e61, topicName=脑小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76c57719730, createdName=thinkibmz_44722596, createdTime=Thu May 26 11:59:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488327, encodeId=0914148832e5e, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Thu May 26 11:59:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497996, encodeId=4bf3149e9964d, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu May 26 11:59:00 CST 2016, time=2016-05-26, status=1, ipAttribution=)]
    2016-10-14 ylzr123

    赞了,认真探究、学习。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1774644, encodeId=bfb81e7464432, content=<a href='/topic/show?id=d0e24e171d1' target=_blank style='color:#2F92EE;'>#小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47171, encryptionId=d0e24e171d1, topicName=小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c7a38663370, createdName=kord1995, createdTime=Mon Apr 17 05:59:00 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148214, encodeId=1c501482141b, content=赞了,认真探究、学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Oct 14 14:12:50 CST 2016, time=2016-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480853, encodeId=771814808534c, content=<a href='/topic/show?id=de508482e61' target=_blank style='color:#2F92EE;'>#脑小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84827, encryptionId=de508482e61, topicName=脑小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76c57719730, createdName=thinkibmz_44722596, createdTime=Thu May 26 11:59:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488327, encodeId=0914148832e5e, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Thu May 26 11:59:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497996, encodeId=4bf3149e9964d, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu May 26 11:59:00 CST 2016, time=2016-05-26, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1774644, encodeId=bfb81e7464432, content=<a href='/topic/show?id=d0e24e171d1' target=_blank style='color:#2F92EE;'>#小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47171, encryptionId=d0e24e171d1, topicName=小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c7a38663370, createdName=kord1995, createdTime=Mon Apr 17 05:59:00 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148214, encodeId=1c501482141b, content=赞了,认真探究、学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Oct 14 14:12:50 CST 2016, time=2016-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480853, encodeId=771814808534c, content=<a href='/topic/show?id=de508482e61' target=_blank style='color:#2F92EE;'>#脑小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84827, encryptionId=de508482e61, topicName=脑小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76c57719730, createdName=thinkibmz_44722596, createdTime=Thu May 26 11:59:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488327, encodeId=0914148832e5e, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Thu May 26 11:59:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497996, encodeId=4bf3149e9964d, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu May 26 11:59:00 CST 2016, time=2016-05-26, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1774644, encodeId=bfb81e7464432, content=<a href='/topic/show?id=d0e24e171d1' target=_blank style='color:#2F92EE;'>#小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47171, encryptionId=d0e24e171d1, topicName=小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0c7a38663370, createdName=kord1995, createdTime=Mon Apr 17 05:59:00 CST 2017, time=2017-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=148214, encodeId=1c501482141b, content=赞了,认真探究、学习。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Oct 14 14:12:50 CST 2016, time=2016-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1480853, encodeId=771814808534c, content=<a href='/topic/show?id=de508482e61' target=_blank style='color:#2F92EE;'>#脑小血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84827, encryptionId=de508482e61, topicName=脑小血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76c57719730, createdName=thinkibmz_44722596, createdTime=Thu May 26 11:59:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488327, encodeId=0914148832e5e, content=<a href='/topic/show?id=b34f1001e187' target=_blank style='color:#2F92EE;'>#预后不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100171, encryptionId=b34f1001e187, topicName=预后不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b86b8414062, createdName=caoliehu, createdTime=Thu May 26 11:59:00 CST 2016, time=2016-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497996, encodeId=4bf3149e9964d, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Thu May 26 11:59:00 CST 2016, time=2016-05-26, status=1, ipAttribution=)]

相关资讯

PLoS One:血清碱性磷酸酶(ALP)水平与脑小血管病相关

背景:血清碱性磷酸酶(ALP)是血管钙化的标志。血清ALP水平较高与心血管事件增加有关,并可预测脑卒中患者功能预后较差。研究者调查血清ALP是否与脑小血管病(CSVD)和大动脉狭窄(LCAS)相关。方法:研究者评估了1011名神经系统健康受试者的血管危险因素,脑MRI及MR血管造影。应用脑MRI评估无症状腔隙性脑梗死(SLI)的存在及中到重度的脑白质高信号(MS-cWMH)作为cSVD的指标。应用

Neurology:甘油三酯增加与脑小血管疾病相关

法国学者对血脂和脑小血管疾病的关系进行了探讨,结果表明,甘油三酯增加与MRI标志物确定的脑小血管疾病有相关性。相关论文10月15日在线发表于《神经病学》(Neurology)杂志。 研究纳入了2608例来自基于人群队列受试者,其中1842例来自3C-Dijon研究,其余766来自血管老化流行病学研究。分别对每项研究进行分析,并混合使用反向方差荟萃分析。对血脂成分作为连续变量进行研究,这些

Baidu
map
Baidu
map
Baidu
map