Kidney Inter：慢性肾病或可改变机体肠道菌群

2012年10月10日 讯 /生物谷BIOON/ --近日，来自加州大学欧文分校的研究者揭示了，慢性肾病可以改变机体肠道细菌菌群的组成，而肠道中细菌的菌群对于机体抵御致病菌及维持微营养平衡至关重要。而在长期效应中，肠道菌群的改变会导致尿毒症毒素、局部炎症及营养失衡的产生。相关研究成果发表在了杂志Kidney International上。

研究者对肾衰竭病人和健康个体的粪便样品进行微生物DNA的提取，经过研究发现，肾衰竭病人的肠道中190种肠道微生物水平明显失衡，而且相同结果在慢性肾脏疾病的大鼠中也得到了证实。

研究者Vaziri解释道，富含氮的废弃物，尤其是尿液或者尿酸，其通常可以在病人体液中积累，这就会导致大部分废弃物通过人类肠道来进行释放，这就使得利用其作为营养物质的微生物群落处于优势地位，慢慢地使得患者肠道的微生物菌群失调。

这项研究再次揭示了肠道微生物在疾病和人类健康中扮演的重要角色，其它研究也同样表明，在糖尿病、癌症、肥胖病人患者机体中，其肠道的微生物菌群也处于明显失调的状态。（生物谷Bioon.com）

编译自：Chronic Kidney Disease Alters Intestinal Microbial Flora

doi:10.1038/ki.2012.345
PMC:
PMID:

Chronic kidney disease alters intestinal microbial flora

Nosratola D Vaziri, Jakk Wong, Madeleine Pahl, Yvette M Piceno, Jun Yuan, Todd Z DeSantis, Zhenmin Ni, Tien-Hung Nguyen and Gary L Andersen

The population of microbes (microbiome) in the intestine is a symbiotic ecosystem conferring trophic and protective functions. Since the biochemical environment shapes the structure and function of the microbiome, we tested whether uremia and/or dietary and pharmacologic interventions in chronic kidney disease alters the microbiome. To identify different microbial populations, microbial DNA was isolated from the stools of 24 patients with end-stage renal disease (ESRD) and 12 healthy persons, and analyzed by phylogenetic microarray. There were marked differences in the abundance of 190 bacterial operational taxonomic units (OTUs) between the ESRD and control groups. OTUs from Brachybacterium, Catenibacterium, Enterobacteriaceae, Halomonadaceae, Moraxellaceae, Nesterenkonia, Polyangiaceae, Pseudomonadaceae, and Thiothrix families were markedly increased in patients with ESRD. To isolate the effect of uremia from inter-individual variations, comorbid conditions, and dietary and medicinal interventions, rats were studied 8 weeks post 5/6 nephrectomy or sham operation. This showed a significant difference in the abundance of 175 bacterial OTUs between the uremic and control animals, most notably as decreases in the Lactobacillaceae and Prevotellaceae families. Thus, uremia profoundly alters the composition of the gut microbiome. The biological impact of this phenomenon is unknown and awaits further investigation.

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