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Br J Surg:二甲双胍或能限制腹主动脉瘤生长

2017-11-06 吴星 环球医学

2017年10月,发表在《Br J Surg》的一项由澳大利亚和新西兰科学家进行的研究考察了二甲双胍与腹主动脉瘤(AAA)生长率之间的相关性。

2017年10月,发表在《Br J Surg》的一项由澳大利亚和新西兰科学家进行的研究考察了二甲双胍与腹主动脉瘤(AAA)生长率之间的相关性。

背景糖尿病药物,如二甲双胍,已被发现或具有抑制AAA生长的作用。本研究的目的为检测糖尿病治疗与AAA生长之间的相关性。

方法:对于AAA生长,队列1使用超声检测,队列2使用重复CT,队列3使用更详细的重复CT。使用最大年平均增长直径评估AAA的生长。

结果:共研究了1697例AAA患者,其中队列1、2和3分别有118、39和16人被开具二甲双胍处方治疗糖尿病。二甲双胍处方与降低3个队列AAA平均生长或更大生长的可能性相关(队列1:调整比值比[OR] 0.59;95% CI,0.39~0.87;P=0.008;队列2:调整OR 0.38,0.18~0.80;P=0.011;队列3:调整OR 0.13,0.03~0.61;P=0.010)。而其他糖尿病治疗药物在3个队列中与AAA生长都没有显着相关性。

结论:这些结果表明,二甲双胍中具有潜在限制AAA生长作用。

原始出处

Golledge J, Moxon J, Pinchbeck J, et al. Association between metformin prescription and growth rates of abdominal aortic aneurysms. Br J Surg. 2017 Oct;104(11):1486-1493. doi: 10.1002/bjs.10587. Epub 2017 Jun 26.

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    2017-11-06 三生有幸9135

    学习一下谢谢分享

    0

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    2017-11-06 doctorJiangchao

    继续学习.

    0

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