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JAMA Intern Med:非阻塞性慢性支气管炎、吸烟与呼吸健康

2020-03-03 MedSci MedSci原创

研究结果表明,非阻塞性慢性支气管炎与不良的呼吸健康结局相关,特别是在吸烟者中

吸烟(电子烟)是年轻慢性支气管炎的重要因素,近日研究人员考察了非阻塞性慢性支气管炎、吸烟与呼吸系统功能之间的关系。

22325名成人参与研究,基线一秒用力呼气量[FEV1]与用力肺活量[FVC]之比<0.70,基线无初始气流阻塞或临床哮喘。非阻塞性慢性支气管炎的定义为咳嗽和痰至少3个月,至少连续2年。采用支气管扩张剂肺活量法测定肺功能,按吸烟状况分层。

参与者平均年龄53.0岁,58.2%为女性,49.6%为曾经吸烟者。在11082名曾经吸烟者中,随访99869人-年,FEV1 (4.1 mL/y)以及FVC(4.7 mL/y)快速下降的非阻塞性慢性支气管炎患者 (300 例,2.7%])的慢性下呼吸道疾病相关的住院或死亡率增加(危险比2.2)。与非阻塞性慢性支气管炎吸烟者相比,呼吸系统疾病相关(HR:2.0)的全因死亡率(HR:1.5)增加。非阻塞性慢性支气管炎与FEV1:FVC下降或气流阻塞无关。至少存在1种非阻塞性慢性支气管炎(即慢性咳嗽或痰)症状与不良的呼吸健康结局相关,这在曾经吸烟者(11.0%)和从未吸烟者(6.7%)中都很常见。

研究结果表明,非阻塞性慢性支气管炎与不良的呼吸健康结局相关,特别是在吸烟者中。

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    2020-04-29 tomyang96
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    2020-03-03 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

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