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Prostate Cancer P D:前列腺癌患者中,家族癌症历史对第二癌症风险和死亡率的影响

2018-09-07 AlexYang MedSci原创

生存率在前列腺癌患者中不断增加,且在这些患者中第二原发癌症(SPCs)越来越普遍。然而,SPCs的病因和临床结果并没有很好的阐释。最近,有研究人员确定了家族历史对这些患者的SPC和死亡原因的影响。研究发现,SPC在6396名男性中诊断,并且超过1/3的患者具有癌症的以及家族历史;具有家族历史的风险为1.37(95% CI: 1.27-1.40),没有家族历史的为1.10(1.08-1.16)。前列

生存率在前列腺癌患者中不断增加,且在这些患者中第二原发癌症(SPCs)越来越普遍。然而,SPCs的病因和临床结果并没有很好的阐释。最近,有研究人员确定了家族历史对这些患者的SPC和死亡原因的影响。

研究发现,SPC在6396名男性中诊断,并且超过1/3的患者具有癌症的以及家族历史;具有家族历史的风险为1.37(95% CI: 1.27-1.40),没有家族历史的为1.10(1.08-1.16)。前列腺癌在年龄到83岁时累积的发病率达到了21%。在这些患者中,SPC占28%;而那些具有SPC和家族历史的占比35%。另外,家族历史与7中特异性的SPCs相关,包括结直肠、肺、肾、膀胱及皮肤(黑色素瘤及鳞状细胞)癌及白血病,并且家族历史能够成倍增加这些SPCs的风险。在患有SPC的患者中,死亡原因的一半是SPC引起,只有12.77%的死因归结于前列腺癌。另外,SPC中的大多数死亡是由肺癌和大肠癌引起。

最后,研究人员指出,SPCs是前列腺癌患者死亡的重要原因,并且家族历史是SPCs的重要风险因子。在前列腺癌生存率增加的同时,SPC的预防是必要的,可以通过前列腺癌诊断时对家族历史进行评估来着手进行。

原始出处:

Subhayan Chattopadhyay, Otto Hemminki, Asta FÖrsti et al. Impact of family history of cancer on risk and mortality of second cancers in patients with prostate cancer. Prostate Cancer P D. 05 Sep 2018.

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    2018-09-09 lsndxfj
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    2018-09-09 cathymary
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    2018-09-09 sunylz
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    2018-09-08 lietome2

    感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!

    0

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慢性炎症是前列腺癌病因学的一个重要因子。巨噬细胞游走抑制因子(MIF)在炎症响应方面具有重要的调节作用。最近,有研究人员调查了MIF-173G/C多样性与前列腺癌发生和生物学行为之间潜在相关性。研究人员在128名前列腺癌受试者和135名对照中利用PCR-RELP技术对MIF的多样性进行了分析。研究发现,MIF-173*C等位基因的频率在前列腺癌患者(19.5%)中要比健康对照个体(10%)显著更高

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前列腺癌(CaP)是老年男性中常见的非上皮癌症。由于前列腺癌的异质性和临床结果和治疗响应的高度可变性,泌尿学家对该疾病的控制仍旧是一个挑战。最近,有研究人员评估了类转酮醇酶1(TKTL1)在良性前列腺组织、瘤旁组织和CaP(疾病不同阶段)中的表达,并评估了与临床病理发现的关系,从而检测TKTL1的表达是否与CaP致瘤过程相关。研究总共包括了100个组织样本。研究发下,TKTL1蛋白的表达模式在良性

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