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NEJM：CDX2作为预后标志物可用于识别高风险二期结肠癌患者

2016-01-22 MedSci MedSci原创

CDX2结肠癌化疗
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确定高风险二期结肠癌是选择患者术后接受辅助治疗的关键。来源于干细胞及祖细胞的基于微阵列的基因表达标志为此带来了希望，但是它们却很难应用于临床实践。

确定高风险二期结肠癌是选择患者术后接受辅助治疗的关键。来源于干细胞及祖细胞的基于微阵列的基因表达标志为此带来了希望，但是它们却很难应用于临床实践。

本研究中研究人员使用新的生物信息学方法来寻找在基因表达阵列中结肠上皮细胞分化的标志物，然后根据临床分级诊断试验的可用性来排列候选基因。研究使用亚组分析，分析了包含结肠癌二期或三期患者的独立和回顾性队列研究，检测了排名靠前的候选基因，以分析其与无病生存率和辅助化疗收益之间的关系。

本研究中CDX2是我们首要检测的转录因子。2115名肿瘤患者中87名（4.1%）患者缺乏CDX2的表达。在此包含466名患者的数据集中，32名CDX2阴性的结肠癌患者的5年无病生存率较434名CDX2阳性的结肠癌患者小。包含了314名患者的验证数据集中，38名CDX2阴性的结肠癌患者的5年无病生存率较276名CDX2阳性的结肠癌患者短。所有亚组分析中，其结果均独立于患者年龄、性别、肿瘤分期及分级。结肠癌二期的患者中，两组数据集中患者的5年无病生存率差异十分明显：发现数据集中（49%的CDX2阴性患者vs. 8.7%的CDX2阳性患者）；验证数据集中（51%的CDX2阴性患者vs. 80%的CDX2阳性患者）。汇集所有患者的数据，23名接受辅助化疗的二期CDX2阴性的结肠癌患者其5年无病生存率较25名未接受辅助化疗的二期CDX2阴性的结肠癌患者大（91% vs. 56%）。

总而言之，本研究发现，可根据患者是否缺乏CDX2的表达来确定高危二期结肠癌患者，这些缺乏CDX2表达的患者或许可从辅助化疗中获益。

原始出处：

Piero Dalerba, , Debashis Sahoo,et al.. CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer.  N Engl J Med 2016; 374:211-222January 21, 2016DOI: 10.1056/NEJMoa1506597

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    2016-06-03 wodejia-dayu

    #CDX2#

    0

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    2016-11-03 xuruicheng

    #预后标志#

    0

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    2016-07-21 hukaixun

    #标志物#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1652642, encodeId=01371652642dd, content=<a href='/topic/show?id=5982442e0f' target=_blank style='color:#2F92EE;'>#CDX2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4427, encryptionId=5982442e0f, topicName=CDX2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e0324309469, createdName=wodejia-dayu, createdTime=Fri Jun 03 10:57:00 CST 2016, time=2016-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819997, encodeId=a10c181999e4d, content=<a href='/topic/show?id=0b11100190a4' target=_blank style='color:#2F92EE;'>#预后标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100190, encryptionId=0b11100190a4, topicName=预后标志)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Thu Nov 03 11:57:00 CST 2016, time=2016-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840870, encodeId=45f018408e0f9, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu Jul 21 18:57:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861990, encodeId=256018619908e, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Dec 29 20:57:00 CST 2016, time=2016-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61317, encodeId=26606131e7f, content=不错，赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61318, encodeId=9d10613184c, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61319, encodeId=11bd6131985, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61320, encodeId=caab613201b, content=值得进一步关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61321, encodeId=e93e61321e0, content=非常实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542676, encodeId=775315426e65e, content=<a href='/topic/show?id=3ef610019167' target=_blank style='color:#2F92EE;'>#预后标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100191, encryptionId=3ef610019167, topicName=预后标志物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b24e13440329, createdName=ms7514935887898259, createdTime=Sun Jan 24 02:57:00 CST 2016, time=2016-01-24, status=1, ipAttribution=)]
    2016-12-29 docwu2019

    #高风险#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1652642, encodeId=01371652642dd, content=<a href='/topic/show?id=5982442e0f' target=_blank style='color:#2F92EE;'>#CDX2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4427, encryptionId=5982442e0f, topicName=CDX2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e0324309469, createdName=wodejia-dayu, createdTime=Fri Jun 03 10:57:00 CST 2016, time=2016-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819997, encodeId=a10c181999e4d, content=<a href='/topic/show?id=0b11100190a4' target=_blank style='color:#2F92EE;'>#预后标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100190, encryptionId=0b11100190a4, topicName=预后标志)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Thu Nov 03 11:57:00 CST 2016, time=2016-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840870, encodeId=45f018408e0f9, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu Jul 21 18:57:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861990, encodeId=256018619908e, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Dec 29 20:57:00 CST 2016, time=2016-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61317, encodeId=26606131e7f, content=不错，赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61318, encodeId=9d10613184c, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61319, encodeId=11bd6131985, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61320, encodeId=caab613201b, content=值得进一步关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61321, encodeId=e93e61321e0, content=非常实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542676, encodeId=775315426e65e, content=<a href='/topic/show?id=3ef610019167' target=_blank style='color:#2F92EE;'>#预后标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100191, encryptionId=3ef610019167, topicName=预后标志物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b24e13440329, createdName=ms7514935887898259, createdTime=Sun Jan 24 02:57:00 CST 2016, time=2016-01-24, status=1, ipAttribution=)]
    2016-01-27 doctording1

    不错，赞一个

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1652642, encodeId=01371652642dd, content=<a href='/topic/show?id=5982442e0f' target=_blank style='color:#2F92EE;'>#CDX2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4427, encryptionId=5982442e0f, topicName=CDX2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e0324309469, createdName=wodejia-dayu, createdTime=Fri Jun 03 10:57:00 CST 2016, time=2016-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819997, encodeId=a10c181999e4d, content=<a href='/topic/show?id=0b11100190a4' target=_blank style='color:#2F92EE;'>#预后标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100190, encryptionId=0b11100190a4, topicName=预后标志)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Thu Nov 03 11:57:00 CST 2016, time=2016-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840870, encodeId=45f018408e0f9, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu Jul 21 18:57:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861990, encodeId=256018619908e, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Dec 29 20:57:00 CST 2016, time=2016-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61317, encodeId=26606131e7f, content=不错，赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61318, encodeId=9d10613184c, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61319, encodeId=11bd6131985, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61320, encodeId=caab613201b, content=值得进一步关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61321, encodeId=e93e61321e0, content=非常实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542676, encodeId=775315426e65e, content=<a href='/topic/show?id=3ef610019167' target=_blank style='color:#2F92EE;'>#预后标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100191, encryptionId=3ef610019167, topicName=预后标志物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b24e13440329, createdName=ms7514935887898259, createdTime=Sun Jan 24 02:57:00 CST 2016, time=2016-01-24, status=1, ipAttribution=)]
    2016-01-27 doctording1

    这篇文章有一定深度

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1652642, encodeId=01371652642dd, content=<a href='/topic/show?id=5982442e0f' target=_blank style='color:#2F92EE;'>#CDX2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4427, encryptionId=5982442e0f, topicName=CDX2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e0324309469, createdName=wodejia-dayu, createdTime=Fri Jun 03 10:57:00 CST 2016, time=2016-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819997, encodeId=a10c181999e4d, content=<a href='/topic/show?id=0b11100190a4' target=_blank style='color:#2F92EE;'>#预后标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100190, encryptionId=0b11100190a4, topicName=预后标志)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Thu Nov 03 11:57:00 CST 2016, time=2016-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840870, encodeId=45f018408e0f9, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu Jul 21 18:57:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861990, encodeId=256018619908e, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Dec 29 20:57:00 CST 2016, time=2016-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61317, encodeId=26606131e7f, content=不错，赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61318, encodeId=9d10613184c, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61319, encodeId=11bd6131985, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61320, encodeId=caab613201b, content=值得进一步关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61321, encodeId=e93e61321e0, content=非常实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542676, encodeId=775315426e65e, content=<a href='/topic/show?id=3ef610019167' target=_blank style='color:#2F92EE;'>#预后标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100191, encryptionId=3ef610019167, topicName=预后标志物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b24e13440329, createdName=ms7514935887898259, createdTime=Sun Jan 24 02:57:00 CST 2016, time=2016-01-24, status=1, ipAttribution=)]
    2016-01-27 doctording1

    是一篇不错的文章

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1652642, encodeId=01371652642dd, content=<a href='/topic/show?id=5982442e0f' target=_blank style='color:#2F92EE;'>#CDX2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4427, encryptionId=5982442e0f, topicName=CDX2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e0324309469, createdName=wodejia-dayu, createdTime=Fri Jun 03 10:57:00 CST 2016, time=2016-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819997, encodeId=a10c181999e4d, content=<a href='/topic/show?id=0b11100190a4' target=_blank style='color:#2F92EE;'>#预后标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100190, encryptionId=0b11100190a4, topicName=预后标志)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Thu Nov 03 11:57:00 CST 2016, time=2016-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840870, encodeId=45f018408e0f9, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu Jul 21 18:57:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861990, encodeId=256018619908e, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Dec 29 20:57:00 CST 2016, time=2016-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61317, encodeId=26606131e7f, content=不错，赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61318, encodeId=9d10613184c, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61319, encodeId=11bd6131985, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61320, encodeId=caab613201b, content=值得进一步关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61321, encodeId=e93e61321e0, content=非常实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542676, encodeId=775315426e65e, content=<a href='/topic/show?id=3ef610019167' target=_blank style='color:#2F92EE;'>#预后标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100191, encryptionId=3ef610019167, topicName=预后标志物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b24e13440329, createdName=ms7514935887898259, createdTime=Sun Jan 24 02:57:00 CST 2016, time=2016-01-24, status=1, ipAttribution=)]
    2016-01-27 doctording1

    值得进一步关注

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1652642, encodeId=01371652642dd, content=<a href='/topic/show?id=5982442e0f' target=_blank style='color:#2F92EE;'>#CDX2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4427, encryptionId=5982442e0f, topicName=CDX2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e0324309469, createdName=wodejia-dayu, createdTime=Fri Jun 03 10:57:00 CST 2016, time=2016-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819997, encodeId=a10c181999e4d, content=<a href='/topic/show?id=0b11100190a4' target=_blank style='color:#2F92EE;'>#预后标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100190, encryptionId=0b11100190a4, topicName=预后标志)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Thu Nov 03 11:57:00 CST 2016, time=2016-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840870, encodeId=45f018408e0f9, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu Jul 21 18:57:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861990, encodeId=256018619908e, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Dec 29 20:57:00 CST 2016, time=2016-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61317, encodeId=26606131e7f, content=不错，赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61318, encodeId=9d10613184c, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61319, encodeId=11bd6131985, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61320, encodeId=caab613201b, content=值得进一步关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61321, encodeId=e93e61321e0, content=非常实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542676, encodeId=775315426e65e, content=<a href='/topic/show?id=3ef610019167' target=_blank style='color:#2F92EE;'>#预后标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100191, encryptionId=3ef610019167, topicName=预后标志物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b24e13440329, createdName=ms7514935887898259, createdTime=Sun Jan 24 02:57:00 CST 2016, time=2016-01-24, status=1, ipAttribution=)]
    2016-01-27 doctording1

    非常实用

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1652642, encodeId=01371652642dd, content=<a href='/topic/show?id=5982442e0f' target=_blank style='color:#2F92EE;'>#CDX2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4427, encryptionId=5982442e0f, topicName=CDX2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e0324309469, createdName=wodejia-dayu, createdTime=Fri Jun 03 10:57:00 CST 2016, time=2016-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819997, encodeId=a10c181999e4d, content=<a href='/topic/show?id=0b11100190a4' target=_blank style='color:#2F92EE;'>#预后标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100190, encryptionId=0b11100190a4, topicName=预后标志)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6595338, createdName=xuruicheng, createdTime=Thu Nov 03 11:57:00 CST 2016, time=2016-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1840870, encodeId=45f018408e0f9, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Thu Jul 21 18:57:00 CST 2016, time=2016-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1861990, encodeId=256018619908e, content=<a href='/topic/show?id=a374102813a1' target=_blank style='color:#2F92EE;'>#高风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102813, encryptionId=a374102813a1, topicName=高风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Thu Dec 29 20:57:00 CST 2016, time=2016-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61317, encodeId=26606131e7f, content=不错，赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61318, encodeId=9d10613184c, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61319, encodeId=11bd6131985, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61320, encodeId=caab613201b, content=值得进一步关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61321, encodeId=e93e61321e0, content=非常实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Wed Jan 27 20:08:00 CST 2016, time=2016-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542676, encodeId=775315426e65e, content=<a href='/topic/show?id=3ef610019167' target=_blank style='color:#2F92EE;'>#预后标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100191, encryptionId=3ef610019167, topicName=预后标志物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b24e13440329, createdName=ms7514935887898259, createdTime=Sun Jan 24 02:57:00 CST 2016, time=2016-01-24, status=1, ipAttribution=)]
    2016-01-24 ms7514935887898259

    #预后标志物#

    0

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