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Stroke:麻醉方法对进行机械取栓的缺血性脑卒中患者预后有啥影响?

2017-01-10 xing.T MedSci原创

在纽约州这一全面的接受机械取栓的缺血性脑卒中患者队列中,研究者发现全身麻醉可增加患者的病死率和住院时间,因此,在规范急性卒中护理时应考虑这些因素。

麻醉技术对进行机械血栓取出术的急性缺血性卒中患者预后的影响仍然是一个争论的问题。近日,卒中领域权威杂志Stroke上发表了一篇研究文章,研究人员探究了全身麻醉与接受机械取栓的缺血性脑卒中患者预后之间的相关性。

研究人员在2009年至2013年期间在接受机械取栓的缺血性脑卒中患者中进行了一项队列研究,这些参与者均在纽约州计划与研究合作系统数据库中进行过注册。研究者采用工具变量(医院的全麻率)分析来模拟随机效应,并探讨了麻醉技术与病死率及住院时间之间的相关性。

在1174例患者中,有441例(37.6%)患者接受全身麻醉,733例(62.4%)患者接受清醒镇静术。使用工具变量分析,研究者发现,相比于清醒镇静术的患者,全身麻醉可导致患者病死率增加6.4%(95%可信区间为1.9%-11.0%),以及住院时间延长8.4天(95%可信区间为2.9-14.0天)。这与为防止出现1例死亡而使15名患者需要进行清醒镇静术相对应。对回归模型调整后,在用混合效应回归和倾向性得分进行的敏感性分析中,这些研究结果同样明显。

由此可见,在纽约州这一全面的接受机械取栓的缺血性脑卒中患者队列中,研究者发现全身麻醉可增加患者的病死率和住院时间,因此,在规范急性卒中护理时应考虑这些因素。 

原始出处:

Kimon Bekelis, et al. Anesthesia Technique and Outcomes of Mechanical Thrombectomy in Patients With Acute Ischemic Stroke. Stroke.2017.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2017-01-13 inter158

    全身麻醉可增加患者的病死率和住院时间,

    0

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