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SCI REP：Th17相关炎性细胞因子与成人哮喘的相关性分析！

2017-11-14 xing.T MedSci原创

Th17相关炎性细胞因子哮喘相关性
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该研究结果表明，IL-17A和IL-9高表达以及脂肪酶、CCL11水平下降与成人哮喘之间呈正相关。

慢性气道炎症被认为是哮喘发病的一个重要过程。细胞因子由免疫细胞和炎症细胞，如T辅助（TH）细胞、嗜酸性粒细胞和中性粒细胞合成分泌，在哮喘患者中，而不仅限于Th2型细胞。然而，很少有人了解Th2型炎性细胞因子与成人哮喘之间的相关性。近日，Scientific reports 杂志上发表了一篇研究文章，该研究针对这一问题对910例成年哮喘患者和881名健康对照者进行了病例对照研究。

研究人员高通量蛋白质芯片技术对炎性细胞因子进行筛选，以及最后确定了Th17细胞相关的炎性细胞因子（IL17A、IL-9、脂肪酶和CCL11）。研究人员采用多元logistic回归模型分析了四种细胞因子与成人哮喘风险之间的关系。

研究人员发现与对照组相比，哮喘患者血浆中IL-17A和IL-9水平显著增加。然而，哮喘患者血浆中脂肪酶和CCL11的表达均显著低于健康对照者。IL-17A、IL-9、脂肪酶、 CCL11的表达与成人哮喘之间相关性调整后的比值比（95%可信区间）分别为3.08（1.91-4.97）、1.93（1.41-2.64）、10.02（6.99-14.37）和3.29（2.36-4.59）（所有趋势P<0.0001）。

该研究结果表明，IL-17A和IL-9高表达以及脂肪酶、CCL11水平下降与成人哮喘之间呈正相关。

原始出处：

Ting Zhou,et al. Associations between Th17-related inflammatory cytokines and asthma in adults: A Case-Control Study.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-15570-8

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    2018-04-20 liuyg0228

    #成人哮喘#

    0

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    2018-05-14 ms7019579240139182

    #胞因子#

    0

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    2017-11-19 shenxlcyp

    #相关性#

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    2017-11-16 axin009

    #细胞因子#

    0

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    2017-11-16 zhaojie88

    #Th17#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1935121, encodeId=92a5193512156, content=<a href='/topic/show?id=85b75384ebe' target=_blank style='color:#2F92EE;'>#成人哮喘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53847, encryptionId=85b75384ebe, topicName=成人哮喘)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c31495, createdName=liuyg0228, createdTime=Fri Apr 20 06:24:00 CST 2018, time=2018-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809551, encodeId=03311809551b9, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Mon May 14 17:24:00 CST 2018, time=2018-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837388, encodeId=c2a6183e388e0, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Sun Nov 19 06:24:00 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283585, encodeId=bbe31283585db, content=<a href='/topic/show?id=2c00e784416' target=_blank style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Thu Nov 16 10:24:00 CST 2017, time=2017-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413551, encodeId=aa90141355172, content=<a href='/topic/show?id=9cd21e364df' target=_blank style='color:#2F92EE;'>#Th17#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17364, encryptionId=9cd21e364df, topicName=Th17)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Nov 16 10:24:00 CST 2017, time=2017-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1523567, encodeId=0876152356ed9, content=<a href='/topic/show?id=f6f1e2533e3' target=_blank style='color:#2F92EE;'>#相关性分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72533, encryptionId=f6f1e2533e3, topicName=相关性分析)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad8f11536374, createdName=anminleiryan, createdTime=Thu Nov 16 10:24:00 CST 2017, time=2017-11-16, status=1, ipAttribution=)]
    2017-11-16 anminleiryan

    #相关性分析#

    0

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