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JAHA:主动脉瓣置换术预后的性别差异!

2017-09-22 MedSci MedSci原创

目前,对于评估性别对主动脉瓣置换(AVR)术后预后影响的研究还甚少。本研究纳入了2003年至2014年行AVR的166809名患者(男性占63%),其中48.5%的患者伴随着其他心脏外科手术。相比于男性患者,女性患者年龄更大,发生非动脉粥样硬化并发症的风险更高,比如高血压、糖尿病、梗阻性肺动脉疾病、房颤和贫血,但是冠心病和外周血管疾病的发生风险更低。女性患者的住院死亡率更高(5.6% vs 4%,

目前,对于评估性别对主动脉瓣置换(AVR)术后预后影响的研究还甚少。本研究纳入了2003年至2014年行AVR的166809名患者(男性占63%),其中48.5%的患者伴随着其他心脏外科手术。相比于男性患者,女性患者年龄更大,发生非动脉粥样硬化并发症的风险更高,比如高血压、糖尿病、梗阻性肺动脉疾病、房颤和贫血,但是冠心病和外周血管疾病的发生风险更低。女性患者的住院死亡率更高(5.6% vs 4%, P<0.001)。为了进一步评估性别对AVR的影响,研究者对研究对象进行了性别匹配,最终产生了28237对患者。在匹配组中,女性的住院死亡率依然更高(3.3% vs 2.9%, P<0.001),血管疾病和输血的风险也更高(6% vs 5.6%, P=0.027 ; 40.4% vs 33.9%, P<0.001)。此外,卒中、起搏器植入和急性肾损伤的发生风险相似。研究结果显示,女性患者的AVR住院死亡率要高于男性,提示女性在接受AVR或经导管AVR治疗的标准要低于男性。原始出处:Zakeih C et al.Sex Differences in the Utilizati

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    2018-01-24 yxch48
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    2017-09-24 zhaohui6731
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