JACC：RLP-C和LDL-TG可以预测心血管事件的发生

2018-07-06 MedSci MedSci原创

高甘油三酯血症患者的残余类颗粒胆固醇（RLP-C）和低密度脂蛋白中的甘油三酯（LDL-TG）水平是增高的，近期的研究主要聚焦在RLP-C，而少有研究LDL-TG的。本研究的目的旨在评估RLP-C和LDL-TG与心血管事件（CVD）发生和ARIC临床研究中的遗传变异的相关性。本研究对9334名无CVD的研究对象进行了血浆快速RLP-C和LDL-TG水平的检测，经过平均16年时间的随访，RLP-C和L

高甘油三酯血症患者的残余类颗粒胆固醇（RLP-C）和低密度脂蛋白中的甘油三酯（LDL-TG）水平是增高的，近期的研究主要聚焦在RLP-C，而少有研究LDL-TG的。本研究的目的旨在评估RLP-C和LDL-TG与心血管事件（CVD）发生和ARIC临床研究中的遗传变异的相关性。

本研究对9334名无CVD的研究对象进行了血浆快速RLP-C和LDL-TG水平的检测，经过平均16年时间的随访，RLP-C和LDL-TG的水平与甘油三酯的水平呈相关性（r = 0.85和r = 0.64， p < 0.0001），最小调整分析后发现RLP-C和LDL-TG的水平与CVD的发生相关，但经传统危险因素调整分析后，仅有LDL-TG与冠心病和卒中的发生相关。另外，一个常见的APOE基因变异（rs7412）与RLP-C和LDL-TG的水平相关性最强（p < 5 × 10-8）。

本研究结果显示，RLP-C和LDL-TG的水平可以预测心血管事件的发生，并与APOE基因变异相关。

原始出处：

Anum S et al.Remnant-Like Particle Cholesterol, Low-Density Lipoprotein Triglycerides, and Incident Cardiovascular Disease.JACC.2018 July.

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2018-11-05 hbwxf

#JACC#

64 0
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2019-02-16 hukaixun

#血管事件#

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2018-07-10 润泽River

学习了.谢谢分享.

114 0
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2018-07-08 12498568m50暂无昵称

#ACC#

48 0
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2018-07-08 zhwj

#LDL#

57 0
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2018-07-06 明崖

学习了.谢谢分享

93 0
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2018-07-06 龙胆草

学习谢谢分享

91 0
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2018-07-06 13718711b3m

学习了.获益匪浅.感谢分享

93 0

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