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Radiology: LI-RADS分类告诉你原发肝癌是哪种类型!

2019-04-27 shaosai MedSci原创

本研究旨在评价原发肝细胞肝癌患者LI-RADS对术后预后意义,验证LI-RADS 2017版在鉴别钆塞酸增强MRI检查中肝细胞肝癌(HCC)与肝内胆管细胞癌(IHCC)及混合肝细胞-胆管细胞癌(cHCC-CC)的价值。

本研究旨在评价原发肝细胞肝癌患者LI-RADS对术后预后意义,验证LI-RADS 2017版在鉴别钆塞酸增强MRI检查中肝细胞肝癌(HCC)与肝内胆管细胞癌(IHCC)及混合肝细胞-胆管细胞癌(cHCC-CC)的价值。

本研究共纳入了194例肝硬化并手术证实为单发原发肝癌的患者(53例cHCC-CC、 44例IHCC和97例HCC患者),并行钆塞酸增强MRI检查。患者平均年龄为57岁,共有155名男性。由2名阅片者对每个结节进行LI-RADS分类。利用Kaplan-Meier法、Log等级检验和Cox比例危害模型评价整体生存期(OS)无复发生存期(RFS)和其相关指标。

结果为,在多元分析中,LI-RADS是OS (OR为 4.2; P < .001)、RFS(OR为2.6; P = .01)的独立指标。LR-M分类显示OS越差与RFS的相关性要强于LR-4或LR-5分类(P < .001)。LR-5分类对诊断HCC的敏感性和特异性分别为69% (67/97) 、 87% (84/97),其中的大假阳性诊断为cHCC-CCs的错误分类(85%, 11/13)。

本研究表明,LI-RADS分类与原发肝癌术后预后意义具有相关性。LI-RADS能够正确对肝细胞肝癌、肝内胆管细胞癌进行分类,但对于鉴别混合肝细胞胆管细胞癌尚不可靠。

原始出处:

Choi SH, Lee SS, Park SH,et al.LI-RADS Classification and Prognosis of Primary Liver Cancers at Gadoxetic Acid-enhanced MRI.Radiology.DOI:10.1148/radiol.2018181290

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    2019-10-04 江川靖瑶
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    2019-10-22 zhanfl
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    2019-04-27 留走人康

    肝癌,接下来就要细分了,对于体质好的病人,能否将PD-1类+抗血管新生+放疗等相结合,甚至有必要用TACE进行减负

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