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SCI REP:同型半胱氨酸与常规易感因素的关系对高血压患者卒中风险的影响!

2018-03-02 xing.T MedSci原创

总之,在预测整体风险和选择卒中预防的某些治疗方法时,需要考虑性别和血压分层与Hcy复杂的相互作用。

以往的研究主要集中于卒中危险因素的独立影响,而对卒中预防中可能重要的个体因素之间的相互作用很少关注。近日,Scientific reports杂志上发表了一篇研究文章,研究人员收集了2258名原发性高血压患者的人口学特征、慢性病史和生活方式因素。

研究人员采用基于比值比(OR)和相应95%可信区间(CI)的logistic回归模型来评估同型半胱氨酸(Hcy)对卒中风险的独立影响,还包括Hcy与其他危险因素之间的相互作用。

对潜在的混杂因素调整后,在高血压患者(OR为1.027;95%CI为1.016-1.038;P<0.001  )和H型高血压患者(OR为1.026;95%CI为1.014-1.037;P<0.001)中,Hcy与卒中风险增加的OR值相关。在高血压参与者中,Hcy与其他危险因素相互作用的三次检验具有统计学意义:性别、收缩压和舒张压。

总之,在预测整体风险和选择卒中预防的某些治疗方法时,需要考虑性别和血压分层与Hcy复杂的相互作用。

原始出处:


Hui Pang,et al. Association between homocysteine and conventional predisposing factors on risk of stroke in patients with hypertension.Scientific reports.2018. https://www.nature.com/articles/s41598-018-22260-6

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


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    2018-03-02 yfjms

    学习

    0

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    2018-03-02 惠映实验室

    学习.谢谢分享.

    0

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    2018-03-02 惠映实验室

    学习.谢谢分享.

    0

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    2018-03-02 183****7028

    学习

    0

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    2018-03-02 1e17414fm02(暂无匿称)

    学习

    0

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