JAMA Neurol：早期脑结构改变与阿尔茨海默病遗传易感性相关

2013-11-28 高晓方译医学论坛网

美国一项研究表明，早期脑结构改变与阿尔茨海默病遗传易感性相关，并有可能成为阿尔茨海默病预防治疗的靶位。论文11月25日在线发表于《美国医学会杂志·神经病学》（JAMA Neurol）。此项研究共纳入162例典型发育的2～25个月婴儿，并在睡眠时实施了脑MRI检查。受试婴儿均无阿尔茨海默病以及其它神经或精神疾病家族史。在载脂蛋白E（APOE）ε4携带者和非携带者中对白质髓鞘水部

美国一项研究表明，早期脑结构改变与阿尔茨海默病遗传易感性相关，并有可能成为阿尔茨海默病预防治疗的靶位。论文11月25日在线发表于《美国医学会杂志·神经病学》（JAMA Neurol）。

此项研究共纳入162例典型发育的2～25个月婴儿，并在睡眠时实施了脑MRI检查。受试婴儿均无阿尔茨海默病以及其它神经或精神疾病家族史。在载脂蛋白E（APOE）ε4携带者和非携带者中对白质髓鞘水部分（MWF）和灰质容积（GMV）进行比较。ε4携带和非携带者在年龄、妊娠期、出生体重和孕母年龄等方面相互匹配。

结果显示，在易受阿尔茨海默病累及的楔前叶、后/中扣带、侧颞叶和中枕颞区中，ε4携带者的MWF和GWM低于非携带者。在广泛前额区中，ε4携带者的MWF和GWM高于非携带者。在2～6个月婴儿中上述结果亦具有统计学意义。在ε4携带者的后白质区中，MWF与年龄的相关性出现减弱。

原文出处：

Douglas C. Dean III; Beth A. Jerskey; Kewei Chen; Hillary Protas; Pradeep Thiyyagura; Auttawat Roontiva; Jonathan O'Muircheartaigh; Holly Dirks; Nicole Waskiewicz; Katie Lehman; Ashley L. Siniard; Mari N. Turk; Xue Hua; Sarah K. Madsen; Paul M. Thompson; Adam S. Fleisher; Matthew J. Huentelman; Sean C. L. Deoni; Eric M. Reiman.Brain Differences in Infants at Differential Genetic Risk for Late-Onset Alzheimer Disease A Cross-sectional Imaging Study.JAMA Neurol. Published online November 25, 2013. doi:10.1001/jamaneurol.2013.4544

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2014-03-17 ms1948154235210413

#阿尔茨#

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2014-03-23 12498da4m32(暂无昵称)

#阿尔茨海#

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2014-06-08 yinhl1978

#Neurol#

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2013-11-30 kcb071

#遗传易感性#

55 0
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2013-11-30 FukaiBao

#易感性#

65 0
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2013-11-30 yhj-time

#阿尔茨海默#

55 0
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2013-11-30 wmr116

#脑结构#

57 0

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