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NEJM:MERS-CoV可引起院内感染

2013-08-02 青楚 cmt

MERS-CoV即新型中东冠状病毒,在2012年9月被首次报道。沙特阿拉伯学者的一项研究显示,MERS-CoV可人传人,并已在当地的一间医院出现院内爆发。在统计期间共出现23个病例,其中21个为院内获得。除此之外,亦有医务人员感染。这种情况可带来较大的死亡负担。相关论文2013年8月1日在线发表于《新英格兰医学杂志》(NEJM)。 该研究记录了临床和人口统计学信息,并确定潜在的接触和暴露。患者和

MERS-CoV即新型中东冠状病毒,在2012年9月被首次报道。沙特阿拉伯学者的一项研究显示,MERS-CoV可人传人,并已在当地的一间医院出现院内爆发。在统计期间共出现23个病例,其中21个为院内获得。除此之外,亦有医务人员感染。这种情况可带来较大的死亡负担。相关论文2013年8月1日在线发表于《新英格兰医学杂志》(NEJM)。

该研究记录了临床和人口统计学信息,并确定潜在的接触和暴露。患者和接触者均受访,评估潜伏期和间隔(传播链中相继出现症状的时间),并对病毒RNA进行测序 。

结果显示,在2013年4月1日到5月23日之间,在沙特东部省份共报道了23例MERS-CoV感染病例。症状包括高烧20例(87%)、咳嗽20例(87%)、气短11例(48%)和胃肠道症状8例(35%)。20例患者(87%)出现 胸部X线检查异常 。到6月12日为止,共有15例患者 (65%)死亡,6例(26%)恢复,2例(9%)还在住院。平均潜伏期为5.2天(95%CI为 1.9-14.7),间隔期为7.6天(95% CI为2.5-23.1)。共有21例患者是在血透室或住院部经人传播感染。在217例家庭接触者和200多位接触患者的医务工作者中,MERS-CoV感染了5位家庭成员(3例为实验室确诊病例)和2位医务人员(均为实验室确诊)。

Assiri A, McGeer A, Perl TM, Price CS, Al Rabeeah AA, Cummings DA, Alabdullatif ZN, Assad M, Almulhim A, Makhdoom H, Madani H, Alhakeem R, Al-Tawfiq JA, Cotten M, Watson SJ, Kellam P, Zumla AI, Memish ZA; the KSA MERS-CoV Investigation Team.Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus.N Engl J Med. 2013 Aug;369(5):407-416. Epub 2013 Jun 19.

PMID:
23782161

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    2013-11-22 anminleiryan
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