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JCEM:生长激素治疗会对Prader-Willi综合征患者的脂肪产生什么影响?

2016-09-26 Moon 译 MedSci原创

Prader-Willi综合征(PWS)成年患者与按BMI匹配的对照组相比,皮下脂肪比例增加;但是是否是基因型在影响患者的身体成分和代谢呢?目前还存在争议。 研究者进行了本项研究,评估PWS成年患者的身体成分和代谢特征;此外还评估了前次生长激素(GH)治疗的影响。 PWS成年患者(平均年龄:25.5±8.9岁)根据不同遗传亚型,分为缺失型(Del, n=47)或单亲二倍体(UPD,n

Prader-Willi综合征(PWS)成年患者与按BMI匹配的对照组相比,皮下脂肪比例增加;但是是否是基因型在影响患者的身体成分和代谢呢?目前还存在争议。

研究者进行了本项研究,评估PWS成年患者的身体成分和代谢特征;此外还评估了前次生长激素(GH)治疗的影响。

PWS成年患者(平均年龄:25.5±8.9岁)根据不同遗传亚型,分为缺失型(Del, n=47)或单亲二倍体(UPD,n = 26),数据分析时将童年或青春期进行GH治疗考虑在内。在亚组,测量了脂肪细胞大小、禁食时总胃促生长素水平、静息时能量消耗(REE),以及通过Dykens Hyperphagia问卷调查评估参与者是否食欲过盛。

总样本中,Del组的BMI高于UPD组(40.9±11.5 vs. 34.6±9.6 kg/m2, p=0.02),但是在体脂百分比、代谢、脂肪细胞大小、REE和食欲过盛评分或胃促生长素水平上,没有组间差异。

对于既往使用GH治疗的样本中,Del组和UPD组患者的BMI没有差别(33.5±11.1 vs.33.0±9.7kg/m2)。另外,在Del组,既往使用GH治疗与脂粉百分比和脂肪细胞体积的下降有关。

结果表明,对于PWS成年患者,基因缺失与BMI的增加有关。儿童或青少年时期使用GH进行治疗,可以限制这种有害表型效应,改善肥胖相关标记。研究表明,PWS的分子表型和脂肪组织的发育之间存在相关性,并且生长激素会影响两者间的联系。

原始出处:

Coupaye M.et al.Effect of genotype and previous growth hormone treatment on adiposity in adults with Prader-Willi syndrome.J Clin Endocrinol Metab. 2016 Sep 23:jc20162163. [Epub ahead of print]

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    2017-09-06 achengzhao
  2. 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    2016-10-13 smallant2015
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createdName=zhouqu_8, createdTime=Wed Sep 28 08:52:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517476, encodeId=5963151e476c9, content=<a href='/topic/show?id=292c696301a' target=_blank style='color:#2F92EE;'>#生长激素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69630, encryptionId=292c696301a, topicName=生长激素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=baae11082219, createdName=ms6747015003810650, createdTime=Wed Sep 28 08:52:00 CST 2016, time=2016-09-28, status=1, ipAttribution=)]
    2016-10-11 1e0d99ddm02(暂无匿称)

    总结的很好!

    0

  4. 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style='color:#2F92EE;'>#激素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66836, encryptionId=b1d766836e4, topicName=激素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfa6343, createdName=aliceclz, createdTime=Wed Sep 28 08:52:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430686, encodeId=e0ca143068641, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Sep 28 08:52:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517476, encodeId=5963151e476c9, content=<a href='/topic/show?id=292c696301a' target=_blank style='color:#2F92EE;'>#生长激素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69630, encryptionId=292c696301a, topicName=生长激素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=baae11082219, createdName=ms6747015003810650, createdTime=Wed Sep 28 08:52:00 CST 2016, time=2016-09-28, status=1, ipAttribution=)]
    2016-10-11 1e0d99ddm02(暂无匿称)

    总结的很好!

    0

  5. 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createdName=zhouqu_8, createdTime=Wed Sep 28 08:52:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517476, encodeId=5963151e476c9, content=<a href='/topic/show?id=292c696301a' target=_blank style='color:#2F92EE;'>#生长激素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69630, encryptionId=292c696301a, topicName=生长激素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=baae11082219, createdName=ms6747015003810650, createdTime=Wed Sep 28 08:52:00 CST 2016, time=2016-09-28, status=1, ipAttribution=)]
    2016-10-11 1e0d99ddm02(暂无匿称)

    分享一下!

    0

  6. 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style='color:#2F92EE;'>#激素治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66836, encryptionId=b1d766836e4, topicName=激素治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bfa6343, createdName=aliceclz, createdTime=Wed Sep 28 08:52:00 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430686, encodeId=e0ca143068641, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, 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    2016-10-01 doctorJiangchao

    继续关注

    0

  7. 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    2016-10-01 doctorJiangchao

    继续学习

    0

  8. 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  9. 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