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J Periodontol:芳香酶抑制剂可增加乳腺癌患者患牙周炎的风险

2015-05-17 MedSci MedSci原创

J Periodontol:芳香酶抑制剂可增加乳腺癌患者患牙周炎的风险 近日有研究表明辅助性使用AI治疗可增加患者患牙周炎的危险,该研究与2015年2月12日在线发表于 JOURNAL OF PERIODONTOLOGY《牙周病学杂志》。芳香酶抑制剂(AI)的应用可导致雌激素水平降低,进而影响骨质密度(BMD)。牙周炎,牙槽骨丧失以及牙齿的丧失均与BMD过低有关。本研究的目的是评估接受A


近日有研究表明辅助性使用AI治疗可增加患者患牙周炎的危险,该研究与2015年2月12日在线发表于 JOURNAL OF PERIODONTOLOGY《牙周病学杂志》。

芳香酶抑制剂(AI)的应用可导致雌激素水平降低,进而影响骨质密度(BMD)。牙周炎,牙槽骨丧失以及牙齿的丧失均与BMD过低有关。本研究的目的是评估接受AI治疗的绝经后早期(I-IIIA)乳腺癌(BCa)女性生存者的牙周炎患病率,牙周健康状况及唾液中的生物标志物。

研究纳入58名绝经妇女,其中29名为接受AIs治疗的乳腺癌患者,另外29名为非乳腺癌绝经女性。通过测定(1)牙周探诊深度(PD);(2)探诊出血(BoP);(3)牙周附着丧失(AL)来评估每位研究对象的牙周基础状况。此外,通过问卷调查来收集研究对象的人口及牙科利用信息。最后,通过线性回归模型来分析研究结果。

结果发现,在牙周平均PD及剩余牙齿数量上两组之间并没有差异。与对照组相比,AI组牙周BoP的位点(27.8 vs. 16.7; p = 0.02),严重牙周AL的位点(5.2 mm vs. 4.0 mm; p < 0.01)以及存在牙结石的位点(18.2 vs. 6.4; p < 0.001)均明显增多。校正研究对象的经济收入,吸烟,牙科保险及既往放化疗史后,线性回归表明:AI的使用可使CAL增加2mm以上(95% CI: 0.46 -3.92)。BCa组中的唾液中骨钙素和肿瘤坏死因子的中位数水平明显高于对照组。

原始出处:

Taichman LS, Inglehart MR, Giannobile WV, Braun T, Kolenic G, Van Poznak C.Periodontal Health in Women With Early Stage Postmenopausal Breast Cancer Newly on Aromatase Inhibitors: APilot Study.J Periodontol. 2015 Feb 12:1-14. 

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    2016-02-07 jklm09
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    2015-09-06 feather89
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    2015-06-09 ljjj1053

    认真学习了

    0

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    2015-05-19 heli0118
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