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J Periodontol：牙周炎患者中抗蛋白酶TRAPIN-2与促炎细胞因子呈负相关

2018-02-23 MedSci MedSci原创

炎症Trappin-2IL-1β
关注

Trappin-2是一种有效的具有抗炎特性的生物活性丝氨酸蛋白酶抑制剂，也被称为"警报抗蛋白酶"。虽然trappin-2在几种慢性感染中的重要性已被证明，但其可能参与牙周炎仍未定义。本研究旨在探讨牙周健康个体和牙龈炎或广泛性慢性牙周炎（CP）或侵袭性牙周炎（GAgP）患者唾液中trappin-2和白细胞介素（IL）-1β水平。

Trappin-2是一种有效的具有抗炎特性的生物活性丝氨酸蛋白酶抑制剂，也被称为"警报抗蛋白酶"。虽然trappin-2在几种慢性感染中的重要性已被证明，但其可能参与牙周炎仍未定义。本研究旨在探讨牙周健康个体和牙龈炎或广泛性慢性牙周炎（CP）或侵袭性牙周炎（GAgP）患者唾液中trappin-2和白细胞介素（IL）-1β水平。

在全口牙周检查前收集80名全身健康和不吸烟的个体的未刺激的唾液样本。通过酶联免疫吸附试验分析Trappin-2和IL-1β，并在校准总蛋白水平后以ng/mg表示。相关性分析显示trappin-2和IL-1β水平之间呈负相关。 Trappin-2也与临床牙周参数呈显着负相关，与IL-1β呈正相关。与健康个体相比，CP和GAgP患者的Trappin-2水平显着降低，但牙龈炎没有。 trappin-2的唾液浓度降低对区分健康和牙周炎具有高度的敏感性和特异性。

结论：在牙周健康者的唾液中Trappin-2作为"抗惊厥"蛋白酶，相当丰富。与健康个体相比，牙周炎患者唾液中trappin-2减少和IL-1β水平升高可能意味着潜在的抗蛋白酶/促炎细胞因子失衡，导致宿主保护能力受损。

原始出处：

Beral Afacan， et al. Alarm anti‐protease trappin‐2 negatively correlates with proinflammatory cytokines in patients with periodontitis. Journal of Periodontology. 2018 January. doi：10.1902/jop.2017.170245

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    2018-05-29 仁医06

    #TRA#

    0

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    2018-04-02 ms7019579240139182

    #胞因子#

    0

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    2018-10-20 ms6127405442416114

    #促炎#

    0

  4. 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    2018-04-01 医者仁心

    #蛋白酶#

    0

  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291219, encodeId=4d94291219c4, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Feb 27 01:06:38 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291218, encodeId=735429121823, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, 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    2018-06-08 xue8602

    #TRAP#

    0

  6. 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    2018-02-28 yykkxiaodou

    #促炎细胞因子#

    0

  7. 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    2018-10-24 feather89

    #PE#

    0

  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291219, encodeId=4d94291219c4, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Feb 27 01:06:38 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291218, encodeId=735429121823, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Feb 27 01:06:32 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290929, encodeId=1d32290929bc, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Feb 26 00:53:44 CST 2018, time=2018-02-26, status=1, ipAttribution=)]
    2018-02-27 jihuaijun1112

    学习学习学习

    0

  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291219, encodeId=4d94291219c4, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Tue Feb 27 01:06:38 CST 2018, time=2018-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291218, encodeId=735429121823, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, 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    2018-02-27 jihuaijun1112

    学习学习学习

    0

  10. 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    2018-02-26 jihuaijun1112

    学习学习学习

    0

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本实验旨在研究实验性牙周炎（PD）的小鼠模型中鼠李糖乳杆菌GG（LGG）对骨吸收和局部及全身炎症的作用。

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由此可见，CHD-APAH患者炎症生物标志物水平升高。呼吸道生理的显著异常可能导致呼吸困难，但不受循环和痰液细胞因子的影响。增加的血清内皮素-1和气道功能障碍之间的关系可能与支气管收缩性能相关。

Am J Resp Crit Care：血小板调节肺结核的炎症和组织破坏！

由此可见，血小板促进TB患者炎症和组织降解。

J Thromb Haemost：长期癌症幸存者的凝血功能和炎症！

由此可见，与没有癌症病史的患者相比，癌症幸存者表现出更严重的炎症和凝血功能。长期癌症幸存者的整体死亡率增加独立于传统CVRFs。这些结果强调有必要开展进一步研究以调查血浆生物标志物作为癌症幸存者心血管危险因素的补充。

J Exp Med：炎症导致的疾病，与某蛋白质的自我切割...

近日，澳大利亚昆士兰大学（UQ）的研究人员发现一种炎症过程在健康细胞中自动关闭的方式，这很可能是阻止多种常见疾病（包括肝脏疾病、阿尔兹海默症和痛风）中不受控炎症造成伤害的关键。现在，他们正在研究手动停止这一过程的方法。该研究已于近日发表在《Journal of Experimental Medicine》上。

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