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Hypertension:尿钾排泄减少与高血压风险升高相关

2014-07-25 高晓方 译 医学论坛网

荷兰一项研究表明,尿钾排泄减少与罹患高血压风险升高具有相关性;增加膳食钾摄入至90 mmol/天可减少高血压发生。论文于7月21日在线发表于《高血压》(Hypertension)杂志。 此项前瞻性研究共纳入5511例年龄为28~75岁的血压正常受试者。受试者在基线时均未应用降压药物。基线和随访中期时利用24小时尿样测定钾排泄。中位随访时间为7.6年。 结果显示,基线中位钾排泄为70 mmol/

荷兰一项研究表明,尿钾排泄减少与罹患高血压风险升高具有相关性;增加膳食钾摄入至90 mmol/天可减少高血压发生。论文于7月21日在线发表于《高血压》(Hypertension)杂志。

此项前瞻性研究共纳入5511例年龄为28~75岁的血压正常受试者。受试者在基线时均未应用降压药物。基线和随访中期时利用24小时尿样测定钾排泄。中位随访时间为7.6年。

结果显示,基线中位钾排泄为70 mmol/24 h,相当于膳食钾摄入91 mmol/24 h。随访期间1172例受试者出现高血压。

多变量校正之后,与钾排泄为中、高三分位的受试者相比,低三分位者出现高血压风险升高(危险比[HR] 1.20)。钾排泄减少导致的高血压占整体高血压的6.2%。钠/钾排泄比与高血压风险无相关性。

原始出处:


Kieneker LM1, Gansevoort RT1, Mukamal KJ1, de Boer RA1, Navis G1, Bakker SJ1, Joosten MM2.Urinary Potassium Excretion and Risk of Developing Hypertension: The Prevention of Renal and Vascular End-Stage Disease Study.Hypertension. 2014 Jul 21. pii: HYPERTENSIONAHA.114.03750. [Epub ahead of print]

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    2015-05-05 维他命
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    2015-02-14 feather89
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