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PLOS Med:儿童期创伤性脑损伤会导致长期的健康问题

2016-09-01 Moon 译 MedSci原创

近期有数据显示,儿童期创伤性脑损伤与长期的健康问题具有潜联系。研究人员进一步得出结论,应该对儿童和青少年制定年龄特异性的临床指导方针和预防策略。 来自牛津大学的Amir Sariaslan博士和同事们对1985-1973年之间的1143470名参与者(来自瑞典出生队列)进行了研究,探究儿童期创伤性脑损伤、成人死亡率、精神病发病率和社会结果之间的关联。最终研究者纳入了104290名在≤25岁时

近期有数据显示,儿童期创伤性脑损伤与长期的健康问题具有潜在联系。研究人员进一步得出结论,应该对儿童和青少年制定年龄特异性的临床指导方针和预防策略。

来自牛津大学的Amir Sariaslan博士和同事们对1985-1973年之间的1143470名参与者(来自瑞典出生队列)进行了研究,探究儿童期创伤性脑损伤、成人死亡率、精神病发病率和社会结果之间的关联。最终研究者纳入了104290名在≤25岁时有过至少一次的创伤性脑损伤患者,同时纳入68268名未受影响的同胞兄弟姐妹。

从26岁开始,对参与者平均随访8年;分析数据显示,创伤性脑损伤与专家诊断精神疾病绝对风险超过10%有关,与低教育程度有关。此外,创伤性脑损伤还与残疾养老金绝对风险、早死绝对风险有关,比例分别占到近5%、2%。

校正性别、出生年份和出生顺序等混杂因素后,研究者发现,创伤性脑损伤与以下情况的最高相对风险如下:精神病住院治疗(aRR = 2; 95% CI, 1.9-2; 6632 vs. 37095)、伤残抚恤金(aRR = 1.8; 95% CI, 1.7-1.8; 4691 vs. 29778)和早死(aRR = 1.7; 95% CI, 1.6-1.9; 799 vs. 4695)。

对不同创伤性脑损伤发作次数的患者进行比较后发现,多次发作者与仅发作一次的患者相比,伤残抚恤金的风险增加近3倍(aRR = 2.6; 95% CI, 2.4-2.8)。首次受伤时间为20-24岁的患者与0-4岁时首次受伤的患者相比,所有结局的风险增加25%以上。

Sariaslan和他的同事写道:“目前大部分头部受伤的儿童没有接受系统的长期随访;我们的研究结果表明,儿童期创伤性脑损伤与长期的健康问题具有潜在联系,在以后应该完善该方面的随访,及早识别相关的精神后果等。”

原始出处:

[1] Childhood traumatic brain injury linked to long-term health issues. Healio.2016 August 31.


[2] Sariaslan A, et al. Long-Term Outcomes Associated with Traumatic Brain Injury in Childhood and Adolescence: A Nationwide Swedish Cohort Study of a Wide Range of Medical and Social Outcomes. PLOS Med. 2016;doi:10.1371/journal.pmed.1002103.

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    2016-11-27 amyloid
  2. 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    2016-09-06 李东泽

    很好,不错,以后会多学习

    0

  3. 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encodeId=9596139e0532c, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sat Sep 03 03:52:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596255, encodeId=fcf5159625564, content=<a href='/topic/show?id=76172e956f2' target=_blank style='color:#2F92EE;'>#健康问题#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27956, encryptionId=76172e956f2, topicName=健康问题)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64a918348691, createdName=xzw119, createdTime=Sat Sep 03 03:52:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607077, encodeId=db2a160e0770b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Sep 03 03:52:00 CST 2016, time=2016-09-03, status=1, ipAttribution=)]
    2016-09-05 李东泽

    很好,不错,以后会多学习

    0

  4. 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topicName=健康问题)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64a918348691, createdName=xzw119, createdTime=Sat Sep 03 03:52:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607077, encodeId=db2a160e0770b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Sep 03 03:52:00 CST 2016, time=2016-09-03, status=1, ipAttribution=)]
    2016-09-05 李东泽

    很好,不错,以后会多学习

    0

  5. 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topicName=健康问题)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64a918348691, createdName=xzw119, createdTime=Sat Sep 03 03:52:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607077, encodeId=db2a160e0770b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Sep 03 03:52:00 CST 2016, time=2016-09-03, status=1, ipAttribution=)]
    2016-09-05 李东泽

    很好,不错,以后会多学习

    0

  6. 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encodeId=9596139e0532c, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sat Sep 03 03:52:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596255, encodeId=fcf5159625564, content=<a href='/topic/show?id=76172e956f2' target=_blank style='color:#2F92EE;'>#健康问题#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27956, encryptionId=76172e956f2, topicName=健康问题)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64a918348691, createdName=xzw119, createdTime=Sat Sep 03 03:52:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607077, encodeId=db2a160e0770b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Sep 03 03:52:00 CST 2016, time=2016-09-03, status=1, ipAttribution=)]
    2016-09-04 ylzr123

    赞,拜读,得深入学习!

    0

  7. 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topicName=健康问题)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64a918348691, createdName=xzw119, createdTime=Sat Sep 03 03:52:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607077, encodeId=db2a160e0770b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Sep 03 03:52:00 CST 2016, time=2016-09-03, status=1, ipAttribution=)]
  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 04 21:01:00 CST 2016, time=2016-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335107, encodeId=71da133510e71, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Sat Sep 03 03:52:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397053, 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  9. 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