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Acta Otolaryngol:肉毒杆菌毒素A注射对中耳炎积液保护性影响的评估

2017-05-01 AlexYang MedSci原创

最近,有研究人员就肉毒杆菌毒素A对小鼠中耳炎积液的影响进行了研究。研究人员将24只雄性维斯塔白鼠分成3组。组1:肉毒杆菌毒素A和组织胺(鼓室内0.2毫升);组2:生理盐水和组织胺(鼓室内0.2毫升);组3:组织胺(鼓室内0.2毫升)。另外,研究人员将组织胺(鼓室内0.2毫升)处理了所有组别的右耳。从研究开始的第5、10、15、和20天,研究人员进行了DPOAE和ABR测试。研究发现,在所有组别中并

最近,有研究人员就肉毒杆菌毒素A对小鼠中耳炎积液的影响进行了研究。研究人员将24只雄性维斯塔白鼠分成3组。组1:肉毒杆菌毒素A和组织胺(鼓室内0.2毫升);组2:生理盐水和组织胺(鼓室内0.2毫升);组3:组织胺(鼓室内0.2毫升)。另外,研究人员将组织胺(鼓室内0.2毫升)处理了所有组别的右耳。从研究开始的第5、10、15、和20天,研究人员进行了DPOAE和ABR测试。

研究发现,在所有组别中并没有发现DPOAE和ABR得分的显著差异。而在每一个组别中,DPOAE右耳得分在第五天处理时,和基础得分比较有显著的降低。在每个组别之间,DPOAE右耳得分在第5、10和15天时没有发现显著的差异。最后,研究人员指出,肉毒杆菌毒素A阻碍了中耳腺体的分泌并且没有表现出阻止浆液性中耳炎的形成。另外,肉毒杆菌毒素^也并没有导致耳蜗任何的形态变化。

原始出处:

Calim ÖF, Yildirim YS, Dogan R et al. Evaluation of the protective effect of Botulinum toxin type A injection on otitis media with effusion. Acta Otolaryngol. 22 April 2017. doi: 10.1080/00016489.2017.1314008.

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