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Eur Respir J:血清25羟维生素D水平与肺癌及组织学类型的关系!

2018-06-09 xing.T MedSci原创

由此可见,孟德尔随机分析并没有表明25(OH)D水平与肺癌的总体风险或组织类型之间存在因果关联。

近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员旨在明确血清25羟维生素D(25(OH)D)水平与肺癌总体发病率和组织学类型之间潜在的因果关系。

研究人员在挪威进行了一项孟德尔随机分析,纳入了54580例对照者和676例肺癌病例。基于维生素D增加的等位基因RS2282679、RS1278588和RS1071657数得到25(OH)D等位基因评分。研究人员估计了与等位基因得分相关的肺癌发病率和组织学类型的风险比和95%可信区间。研究人员采用逆方差加权法汇总了单个单核苷酸多态性的数据,其被用来计算孟德尔随机化估计。

等位基因得分占血清25(OH)D水平变化的3.4%。等位基因得分与肺癌发病率无相关性,每增加一个等位基因的风险比为0.99(95%可信区间为0.93-1.06)。基因决定的25(OH)D水平增加25nmol·L·-1与肺癌的总体发病率(孟德尔随机化估计的风险比为0.96,95%可信区间为0.54-1.69)或任何组织学类型无关。

由此可见,孟德尔随机分析并没有表明25(OH)D水平与肺癌的总体风险或组织类型之间存在因果关联。

原始出处:

Yi-Qian Sun,et al. Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomisation analysis of the HUNT study. Eur Respir J. 2018. http://erj.ersjournals.com/content/51/6/1800329

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    2018-06-15 大爰

    好文章学习并分享!!

    0

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    2018-06-12 12282355m97暂无昵称

    学习了

    0

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    2018-06-11 12282355m97暂无昵称

    学习了

    0

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    2018-06-10 12282355m97暂无昵称

    学习了

    0

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    2018-06-10 phoebeyan520

    学习了受益匪浅!

    0

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    2018-06-09 大爰

    好文章学习并分享!!

    0

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