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Eur Heart J:这个病也是认知衰退与痴呆的风险因素

2017-09-25 安雅晶 环球医学

2017年9月,发表在《Eur Heart J》的一项由法国和英国科学家进行的研究表明,房颤(AF)为认知衰退与痴呆的风险因素。

2017年9月,发表在《Eur Heart J》的一项由法国和英国科学家进行的研究表明,房颤(AF)为认知衰退与痴呆的风险因素。

目的:为了评估AF是否为认知功能障碍的风险因素,研究者使用了随访超过45~85年患者的AF、重复认知评分、痴呆发病率的前瞻性数据。

方法和结果:数据来自于Whitehall II研究,该研究于1985年进行,患者数为10308。7428人(414人为AF,1997年时为45~69岁)接受了4次认知测试(1997~2013)。调整了社会人口学、行为和慢性病后,与无AF参与者相比,较长AF病程(5、10或15年)的参与者认知衰退更快(P=0.01)。卒中或冠心病患者不能解释过度的认知衰退,然而,当将二者一并考虑的时候,该相关性受到了影响(P=0.09)。对于痴呆(274/9302无AF,50/912有AF),调整了社会人口学因素、健康行为和慢性病的Cox回归显示,AF与较高的痴呆风险相关(HR,1.87;95% CI,1.37~2.55)。多状态模型显示,随访期AF可增加无卒中者的痴呆风险(HR,1.67;1.17~2.38),但是不能增加无卒中和冠心病者的痴呆风险(1.29;0.74~2.24)。

结论:45~85岁个体中,AF与认知的加速衰退和较高的痴呆风险相关,甚至在AF发病率很低的年龄时也是如此。AF患者中的心血管疾病至少可部分解释该现象。

原始出处:
Singh-Manoux A, Fayosse A, Sabia S, et al.Atrial fibrillation as a risk factor for cognitive decline and dementia.Eur Heart J. 2017 Sep 7;38(34):2612-2618. doi: 10.1093/eurheartj/ehx208.

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    2017-10-02 ren1mw

    学习一下!谢谢分享

    0

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    2017-09-27 大爰

    学习了谢谢分享!!

    0

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    2017-09-27 zhaojie88
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    2017-09-27 slcumt
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    2017-09-26 ren1mw

    学习了!谢谢分享

    0

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    2017-09-25 往日如昨

    继续学习中谢谢

    0

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    2017-09-25 有备才能无患

    45~85岁个体中.AF与认知的加速衰退和较高的痴呆风险相关.甚至在AF发病率很低的年龄时也是如此.AF患者中的心血管疾病至少可部分解释该现象.

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