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Clin Gastroenterol H:结肠息肉切除术后30天内出血的处理和预后

2020-04-26 MedSci原创 MedSci原创

DPPB患者经常过度使用了结肠镜检查。研究人员确定了活动性出血的独立危险因素,可用于确定最有可能从结肠镜检查中受益的患者。

息肉切除术后延迟(30天内)出血(DPPB)的治疗尚未标准化。患者经常接受结肠镜检查,并没有任何益处。近日,消化病领域权威杂志Clinical Gastroenterology and Hepatology发表了一篇研究文章,研究人员旨在明确与DPPB术后治疗干预和活动性出血相关的因素。

研究人员于2010年1月至2018年9月期间在西班牙的6个三级中心对548例息肉切除术后30天内出血的患者进行了回顾性研究(DPPB; 71.9%的患者接受了结肠镜检查,2.6%的患者接受了血管造影栓塞,25.5%的患者无需干预)。研究人员收集了患者的人口统计学和临床数据。该研究的主要结局是需要治疗干预和结肠镜检查期间活动性出血。

需要治疗干预与使用抗血栓药、血红蛋白降低>2g/dL、血流动力学不稳定和合并症独立相关(P<0.05)。344例患者在结肠镜检查时发现了出血点;有74名(21.5%)患者中存在活动性出血。积极使用抗凝剂(比值比[OR]为2.6;95%CI为1.5-4.5)、左侧息肉(OR为1.95;95%CI为1-3.8)、既往使用电灼术(OR为2.6;95%CI为1.1–6.1)和带蒂息肉(OR为1.8,95%CI为1-3.2)显著增加了发生活动性出血的风险。总体而言,该队列中有43%的患者不需要任何止血疗法。在没有干预患者中,再出血(<6%)和需要输血的几率较低。

由此可见,几乎有一半DPPB患者不需要任何治疗干预,DPPB患者经常过度使用了结肠镜检查。研究人员确定了活动性出血的独立危险因素,可用于确定最有可能从结肠镜检查中受益的患者。

原始出处:

E. Rodríguez de Santiago.et al.Management and Outcomes of Bleeding Within 30 Days of Colonic Polypectomy in a Large, Real-life Multicenter Cohort Study.Clinical gastroenterology and hepatology.2020.https://www.cghjournal.org/inpress

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    2020-09-15 smlt2008
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    2021-01-06 许安
  5. [GetPortalCommentsPageByObjectIdResponse(id=1712402, encodeId=c71c1e1240205, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Aug 14 10:52:35 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877287, encodeId=9afa18e728751, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sun Oct 18 18:52:35 CST 2020, time=2020-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977833, encodeId=fd0119e783378, content=<a href='/topic/show?id=93a211600a' target=_blank style='color:#2F92EE;'>#30天#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1160, encryptionId=93a211600a, topicName=30天)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Tue Sep 15 10:52:35 CST 2020, time=2020-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072979, encodeId=c18520e297901, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Wed Jan 06 20:52:35 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=382422, encodeId=8fd93824220e, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat May 02 13:47:16 CST 2020, time=2020-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2065053, encodeId=5e1a2065053d6, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Mon Aug 03 01:52:35 CST 2020, time=2020-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601289, encodeId=3ede160128965, content=<a href='/topic/show?id=3b70528e12b' target=_blank style='color:#2F92EE;'>#息肉切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52871, encryptionId=3b70528e12b, topicName=息肉切除术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b06c18868349, createdName=canlab, createdTime=Tue Apr 28 06:52:35 CST 2020, time=2020-04-28, status=1, ipAttribution=)]
    2020-05-02 wxl882001

    了解一下

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=1712402, encodeId=c71c1e1240205, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Aug 14 10:52:35 CST 2020, time=2020-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877287, encodeId=9afa18e728751, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Sun Oct 18 18:52:35 CST 2020, time=2020-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977833, encodeId=fd0119e783378, content=<a href='/topic/show?id=93a211600a' target=_blank style='color:#2F92EE;'>#30天#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1160, encryptionId=93a211600a, topicName=30天)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Tue Sep 15 10:52:35 CST 2020, time=2020-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072979, encodeId=c18520e297901, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Wed Jan 06 20:52:35 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=382422, encodeId=8fd93824220e, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat May 02 13:47:16 CST 2020, time=2020-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2065053, encodeId=5e1a2065053d6, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Mon Aug 03 01:52:35 CST 2020, time=2020-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601289, encodeId=3ede160128965, content=<a href='/topic/show?id=3b70528e12b' target=_blank style='color:#2F92EE;'>#息肉切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52871, encryptionId=3b70528e12b, topicName=息肉切除术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b06c18868349, createdName=canlab, createdTime=Tue Apr 28 06:52:35 CST 2020, time=2020-04-28, status=1, ipAttribution=)]

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