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Biomed Mater:生物活性玻璃可显著增加水凝胶的机械性能

2018-01-25 MedSci MedSci原创

与生物相容性、生物诱导性和适当的生物降解一样,机械性能同样也是组织工程支架应具备的中药性能。结冷胶(GG)等水凝胶通常是柔软的材料,可通过掺杂无机颗粒,如生物活性玻璃,不仅提高其生物活性,还可改善其机械性能。可通过多扎红方式评估水凝胶的粘弹性能。本研究中,为了评估添加生物活性玻璃(BAG)对复合水凝胶的粘弹性的影响,研究人员采用并比较了三种最常用的技术,分析它们的优点和局限性:单调单轴无侧限压缩,

与生物相容性、生物诱导性和适当的生物降解一样,机械性能同样也是组织工程支架应具备的中药性能。结冷胶(GG)等水凝胶通常是柔软的材料,可通过掺杂无机颗粒,如生物活性玻璃,不仅提高其生物活性,还可改善其机械性能。可通过多扎红方式评估水凝胶的粘弹性能。

本研究中,为了评估添加生物活性玻璃(BAG)对复合水凝胶的粘弹性的影响,研究人员采用并比较了三种最常用的技术,分析它们的优点和局限性:单调单轴无侧限压缩,小振幅振荡剪切(SAOS)流变学和动态力学分析(DMA)。将DMA中的蠕变和小幅度动态应变控制试验作为表征水凝胶复合材料力学性能的最佳方法,而SAOS流变学因其不会引起体积变化,因此对于研究水凝胶的加工动力学更有用。

结果证实了BAG(纳米)颗粒对GG-BAG复合水凝胶的弹性模量的正向作用。在添加2wt% BAG颗粒(500-800kPa)后,GG水凝胶的6.6±0.8kPa的杨氏模量增加了两个数量级。

原始出处:

Kocen R, Gasik M, Gantar A, Novak S. Viscoelastic behaviour of hydrogel-based composites for tissue engineering under mechanical load. Biomed Mater. 2017 Mar 6;12(2):025004. doi: 10.1088/1748-605X/aa5b00.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2005176, encodeId=d05c20051e68c, content=<a href='/topic/show?id=af6e6938483' target=_blank style='color:#2F92EE;'>#生物活性玻璃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69384, encryptionId=af6e6938483, topicName=生物活性玻璃)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Sat Dec 15 14:09:00 CST 2018, time=2018-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314492, encodeId=273d314492cc, content=偏向材料学, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJu1TYd7JWBGjYppT7VfHb1ZOJpOuhqvn8taH1InVxz4AaPNPeaIa6mTu8m7lHxtVyg71kYCHh11g/132, createdBy=43e62066419, createdName=cococo, createdTime=Sat May 12 19:12:19 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917902, encodeId=f119191e902d3, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Aug 25 05:09:00 CST 2018, time=2018-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308008, encodeId=938b1308008d5, content=<a href='/topic/show?id=edd364149bc' target=_blank style='color:#2F92EE;'>#水凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64149, encryptionId=edd364149bc, topicName=水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Sat Jan 27 05:09:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460948, encodeId=384c1460948fb, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Sat Jan 27 05:09:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608479, encodeId=435e16084e9cb, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Jan 27 05:09:00 CST 2018, time=2018-01-27, status=1, ipAttribution=)]
    2018-05-12 cococo

    偏向材料学

    0

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    2018-08-25 sunylz
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    2018-01-27 tastas
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    2018-01-27 lishizhe
  6. [GetPortalCommentsPageByObjectIdResponse(id=2005176, encodeId=d05c20051e68c, content=<a href='/topic/show?id=af6e6938483' target=_blank style='color:#2F92EE;'>#生物活性玻璃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69384, encryptionId=af6e6938483, topicName=生物活性玻璃)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9df476, createdName=fyxzlh, createdTime=Sat Dec 15 14:09:00 CST 2018, time=2018-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314492, encodeId=273d314492cc, content=偏向材料学, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJu1TYd7JWBGjYppT7VfHb1ZOJpOuhqvn8taH1InVxz4AaPNPeaIa6mTu8m7lHxtVyg71kYCHh11g/132, createdBy=43e62066419, createdName=cococo, createdTime=Sat May 12 19:12:19 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917902, encodeId=f119191e902d3, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Aug 25 05:09:00 CST 2018, time=2018-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308008, encodeId=938b1308008d5, content=<a href='/topic/show?id=edd364149bc' target=_blank style='color:#2F92EE;'>#水凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64149, encryptionId=edd364149bc, topicName=水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Sat Jan 27 05:09:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460948, encodeId=384c1460948fb, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Sat Jan 27 05:09:00 CST 2018, time=2018-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608479, encodeId=435e16084e9cb, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sat Jan 27 05:09:00 CST 2018, time=2018-01-27, status=1, ipAttribution=)]
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