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BMJ:NICE他汀类药物指南应公布需治疗人数及治疗风险

2014-06-23 iang 丁香园

当以需治疗人数(NNT)作为评估他汀获益指标,而非ASCOT-LLA研究中所呈现的他汀治疗可以减少36%心血管疾病发生风险为参照时,他汀获益或许远非如此巨大。英国医学杂志应该质疑目前宣称的他汀治疗益处及其最小化的副作用。英国国家健康临床优化研究院(NICE)发布的指南草案影响力很大,因此必须准确而又通俗易懂地描述指南证据。明确的指南有助于全科医生等采用最佳基于证据的建议规劝患者服药。出于明确性和完

当以需治疗人数(NNT)作为评估他汀获益指标,而非ASCOT-LLA研究中所呈现的他汀治疗可以减少36%心血管疾病发生风险为参照时,他汀获益或许远非如此巨大。英国医学杂志应该质疑目前宣称的他汀治疗益处及其最小化的副作用。


英国国家健康临床优化研究院(NICE)发布的指南草案影响力很大,因此必须准确而又通俗易懂地描述指南证据。明确的指南有助于全科医生等采用最佳基于证据的建议规劝患者服药。

出于明确性和完整性考虑,NICE应该发表他汀在初级预防中的NNTs(或许还应该包括引起1例不良事件需要人数NNH)。全科医生向患者解释NNTs并非难事,我们也希望根据有效的NNTs制定有价值的干预措施。

然而,令人惊讶的是,NICE至今未采用NNTs辅助指南决策。

原始出处:

Tresidder A.NICE should publish numbers needed to treat and harm for statins.BMJ. 2014 Jun 11;348:g3458. doi: 10.1136/bmj.g3458.

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    2015-05-17 gaoxiaoe
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    2014-06-25 fusion

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