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糖尿病患者肿瘤患病率明显增高(REACTION研究)

2017-03-19 谭嘉 健康报

我国一项涉及25万余人的多中心、前瞻性观察研究结果显示,糖代谢异常与部分恶性肿瘤风险增加显着相关,糖尿病病程、胰岛素抵抗也与部分恶性肿瘤患病风险增加相关。在近日于江苏省无锡市举行的2017华东内分泌代谢病论坛上,专家提醒,临床医生和糖尿病患者在控制血糖的同时,也要重视相关肿瘤好发部位的年度体检。据介绍,上海交通大学医学院附属瑞金医院宁光教授,牵头开展了中国2型糖尿病患者肿瘤发生风险的流行病学注册研

我国一项涉及25万余人的多中心、前瞻性观察研究结果显示,糖代谢异常与部分恶性肿瘤风险增加显着相关,糖尿病病程、胰岛素抵抗也与部分恶性肿瘤患病风险增加相关。在近日于江苏省无锡市举行的2017华东内分泌代谢病论坛上,专家提醒,临床医生和糖尿病患者在控制血糖的同时,也要重视相关肿瘤好发部位的年度体检。



据介绍,上海交通大学医学院附属瑞金医院宁光教授,牵头开展了中国2型糖尿病患者肿瘤发生风险的流行病学注册研究(REACTION)。2011年~2017年,25家医疗机构通过社区整群随机抽样开展队列研究,共计调查25.9万人,平均年龄为57±10岁,其中男性占34.67%,女性占65.33%。该研究计划对无恶性肿瘤病史的不同糖代谢人群随访观察5年以上,到2015年已完成3年随访。

上海交通大学医学院附属瑞金医院内分泌科王卫庆教授介绍,从目前的研究结果看,糖尿病患者所有恶性肿瘤患病率显着高于糖尿病前期及正常糖耐量人群。男性正常糖耐量人群所有恶性肿瘤患病率为1.02%,糖尿病前期人群为1.05%,糖尿病患者为1.45%;女性分别为1.86%、2.17%、2.87%。男性糖尿病患者中患病率显着增高的四大恶性肿瘤是结直肠癌肺癌、膀胱癌与肾癌,女性为乳腺癌、子宫内膜癌、结直肠癌与卵巢癌

从病程上看,在所有糖尿病患者中,病程10年以上与结直肠癌、肾癌、膀胱癌患病风险增加显着相关。男性糖尿病患者,病程5年以上与结直肠癌患病风险增加显着相关;女性糖尿病患者,病程10年以上与子宫内膜癌、卵巢癌患病风险增加显着相关。此外,在女性非糖尿病人群中,相对于胰岛素敏感者,胰岛素抵抗的女性乳腺癌、卵巢癌及子宫内膜癌患病风险增加。

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    2017-04-05 hittouch
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  4. 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encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Tue Mar 21 11:45:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567591, encodeId=9c27156e591dc, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Tue Mar 21 11:45:00 CST 2017, time=2017-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181401, encodeId=ea1c1814015f, content=学习了,很有用的!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Mon Mar 20 10:25:25 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181360, encodeId=15e218136005, content=学习了谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Mon Mar 20 09:50:16 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181269, encodeId=5aec18126922, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Mar 20 00:05:55 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181265, encodeId=e47e181265a6, content=跟肝癌关系大不?, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=79351625688, createdName=1dd7a091m35(暂无匿称), createdTime=Mon Mar 20 00:02:54 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181243, encodeId=f54918124330, content=糖代谢异常与部分恶性肿瘤风险增加显着相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Sun Mar 19 22:26:47 CST 2017, time=2017-03-19, status=1, ipAttribution=)]
    2017-03-21 liuxiaona
  5. 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encodeId=f54918124330, content=糖代谢异常与部分恶性肿瘤风险增加显着相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Sun Mar 19 22:26:47 CST 2017, time=2017-03-19, status=1, ipAttribution=)]
    2017-03-21 liuxiaona
  6. 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likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Mar 20 00:05:55 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181265, encodeId=e47e181265a6, content=跟肝癌关系大不?, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=79351625688, createdName=1dd7a091m35(暂无匿称), createdTime=Mon Mar 20 00:02:54 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181243, encodeId=f54918124330, content=糖代谢异常与部分恶性肿瘤风险增加显着相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Sun Mar 19 22:26:47 CST 2017, time=2017-03-19, status=1, ipAttribution=)]
    2017-03-20 明天会更好!

    学习了,很有用的!!!

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Mon Mar 20 10:25:25 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181360, encodeId=15e218136005, content=学习了谢谢了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Mon Mar 20 09:50:16 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181269, encodeId=5aec18126922, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Mar 20 00:05:55 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181265, encodeId=e47e181265a6, content=跟肝癌关系大不?, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=79351625688, createdName=1dd7a091m35(暂无匿称), createdTime=Mon Mar 20 00:02:54 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181243, encodeId=f54918124330, content=糖代谢异常与部分恶性肿瘤风险增加显着相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Sun Mar 19 22:26:47 CST 2017, time=2017-03-19, status=1, ipAttribution=)]
    2017-03-20 186****0580(小山羊)

    学习了谢谢了。

    0

  8. 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likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Mar 20 00:05:55 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181265, encodeId=e47e181265a6, content=跟肝癌关系大不?, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=79351625688, createdName=1dd7a091m35(暂无匿称), createdTime=Mon Mar 20 00:02:54 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181243, encodeId=f54918124330, content=糖代谢异常与部分恶性肿瘤风险增加显着相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Sun Mar 19 22:26:47 CST 2017, time=2017-03-19, status=1, ipAttribution=)]
    2017-03-20 飛歌

    学习了很有用

    0

  9. 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encodeId=f54918124330, content=糖代谢异常与部分恶性肿瘤风险增加显着相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Sun Mar 19 22:26:47 CST 2017, time=2017-03-19, status=1, ipAttribution=)]
    2017-03-20 1dd7a091m35(暂无匿称)

    跟肝癌关系大不?

    0

  10. 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likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Mon Mar 20 00:05:55 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181265, encodeId=e47e181265a6, content=跟肝癌关系大不?, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=79351625688, createdName=1dd7a091m35(暂无匿称), createdTime=Mon Mar 20 00:02:54 CST 2017, time=2017-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=181243, encodeId=f54918124330, content=糖代谢异常与部分恶性肿瘤风险增加显着相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170207/IMG589913E36908D4741.jpg, createdBy=99331680071, createdName=knowheart, createdTime=Sun Mar 19 22:26:47 CST 2017, time=2017-03-19, status=1, ipAttribution=)]
    2017-03-19 knowheart

    糖代谢异常与部分恶性肿瘤风险增加显着相关

    0

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JCO:二甲双胍可以显著改善HER2阳性早期乳腺癌合并糖尿病患者的预后

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Diabetes Care:1型糖尿病患者心电图异常与心血管疾病风险有啥关系?

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Drugs & Aging:老年女性服用他汀类药物后患糖尿病的风险更高

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胰岛素和胰高血糖素如何调节血糖水平

【胰岛素和胰高血糖素之间关系解密】胰腺分泌胰岛素和胰高血糖素,它们在调节血糖水平中起重要作用。这两种激素平衡血糖。如果一种激素的水平在理想范围之外,血糖水平可能飙升或下降。胰岛素和胰高血糖素在一起工作,有助于保持身体内部的条件稳定。当血糖过高时,胰腺分泌更多的胰岛素。当血糖水平下降时,胰腺释放胰高血糖素使其恢复正常。本文主要内容:1.血糖和健康2.血糖调节3.血糖问题引起的糖尿病4.血糖水平如何影

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