ACEI或ARB可减少高血压患者阿尔兹海默病风险

2015-09-21 大鹏译医学论坛网

最新研究结果显示，廉价的降血压治疗同时能保护患者的大脑免受阿尔兹海默病的困扰。与未接受降血压治疗的患者相比，那些服用血管紧张素转换酶抑制剂(ACEI)类或血管紧张素受体拮抗剂(ARB)类药物控制血压的患者罹患阿尔兹海默病的可能性更低。该研究报告同时发表于2015年老年痴呆症协会国际会议。穿过血脑屏障是关键已往研究证实，如果患者中年之前出现高血压，那之后该患者罹患阿尔兹海默症的可能性

最新研究结果显示，廉价的降血压治疗同时能保护患者的大脑免受阿尔兹海默病的困扰。与未接受降血压治疗的患者相比，那些服用血管紧张素转换酶抑制剂(ACEI)类或血管紧张素受体拮抗剂(ARB)类药物控制血压的患者罹患阿尔兹海默病的可能性更低。该研究报告同时发表于2015年老年痴呆症协会国际会议。

穿过血脑屏障是关键

已往研究证实，如果患者中年之前出现高血压，那之后该患者罹患阿尔兹海默症的可能性显著升高。而此研究进一步证实控制血压能降低阿尔兹海默症风险。

研究者入组了784例伴有轻度认知功能障碍的高血压患者，这些患者均接受降压治疗，其中488例患者接受了ACEI类药物或ARB类药物治疗。ACEI类药物及ARB类药物在降压机制上相似，与利尿药、钙离子拮抗剂等其他的降血压药物机制有所不同。患者接受3至5年随访不等。

统计分析结果显示，接受ACEI类药物或ARB类药物治疗的患者罹患阿尔兹海默病可能性显著降低。在ACEI及ARB这些药物中，只有特定的几种能穿过血脑屏障，而当研究者观察服用能穿过血脑屏障药物的患者时，发现他们的阿尔兹海默病风险最低。这种现象与2009年一项类似的研究结果一致。

虽然我们需要更多的研究来支持该结论，但现阶段为高血压患者选择降压药物时，能穿过血脑屏障的ACEI及ARB药物或可以同时保护患者的脑部。

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2016-01-10 41514487@qq.com

#阿尔兹海默病风险#

58 0
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2015-12-14 shanyongle

#ACE#

55 0
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2015-09-23 x35042875

解读EMPA-REG OUTCOME研究作者：河北省人民医院郭艺芳在2015年EASD年会期间，揭晓了举世瞩目的降糖治疗试验EMPA-REG OUTCOME研究结果。

129 0
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2015-09-23 habb

#阿尔兹海默#

53 0
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2015-09-23 维他命

#高血压患者#

56 0
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2015-09-21 lovetcm

应该还要看降幅吧

193 0

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