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JAHA: 早年经历中国大饥荒者,成年后易患心血管病!上海瑞金医院毕宇芳等发表REACTION研究

2020-04-04 朱朱 中国循环杂志

既往研究发现,早年因遭受饥荒而营养不良的人,成年后出现糖尿病和代谢综合征的风险明显增加。

既往研究发现,早年因遭受饥荒而营养不良的人,成年后出现糖尿病和代谢综合征的风险明显增加。

4月1日,上海交通大学医学院附属瑞金医院毕宇芳、陆洁莉等发表的REACTION研究提示,早年遭遇中国大饥荒而营养不良的人,成年后(40岁以后)发生心血管病的风险显著增加,早年生活在严重饥荒地区的人风险更高。

研究者指出,该研究表明,儿童期和青少年时期的营养状况对于成年后心血管病的预防有重要作用。他们认为,早年营养不良与成年后心血管病发生风险之间的关系可能在一定程度上与代谢综合征风险增加有关。

该研究于2011~2012年从全国25个中心纳入近26万名≥40岁的成年人。

结果显示,与从未经历饥荒的人相比,早年经历过饥荒的人中心血管病、心肌梗死、中风、冠心病发生风险显著增加。

多因素logistic回归分析显示,在儿童期经历过饥荒的人中,心血管病、心肌梗死、中风、冠心病发生风险分别增加35%、59%、40%、44%。

在青少年时期经历过饥荒的人中,上述事件的发生风险分别增加52%、107%、92%、83%。

该研究显示,与早年生活在饥荒相对不严重地区的人相比,早年生活在饥荒严重地区的人成年后出现心血管病的风险显著增加。

原始出处:
Rui Du,et al. Early‐Life Famine Exposure and Risk of Cardiovascular Diseases in Later Life: Findings From the REACTION Study. J Am Heart Assoc, 2020, 9: e014175

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    2020-10-07 drj2003
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    2020-08-04 hittouch
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    2020-04-06 zhaohui6731

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