American Journal of Stem Cells: 父亲的年龄和生活方式影响后代的健康状况

2016-05-23 佚名生物谷

据乔治敦大学医学中心的研究员讲述，越来越多的研究表明父亲的年龄，饮酒习惯和环境因素会影响新生儿的出生缺陷。这些缺陷是由表观遗传改变导致的，而且这种变化可能影响很多代。生物化学和分子细胞生物学专业的副教授Joanna Kitlinska博士讲到："众所周知，母亲提供的营养、激素和心理环境会对后代的器官结构、细胞反应和基因表达构成永久性的影响。"但我们的研究表明父亲对后代也有同样的影响。父亲的生

据乔治敦大学医学中心的研究员讲述，越来越多的研究表明父亲的年龄，饮酒习惯和环境因素会影响新生儿的出生缺陷。这些缺陷是由表观遗传改变导致的，而且这种变化可能影响很多代。

生物化学和分子细胞生物学专业的副教授Joanna Kitlinska博士讲到："众所周知，母亲提供的营养、激素和心理环境会对后代的器官结构、细胞反应和基因表达构成永久性的影响。"但我们的研究表明父亲对后代也有同样的影响。父亲的生活方式、年龄会影响某些蛋白分子的功能，从而调控基因的表达。因此，父亲不仅会影响他的直接后代，还会影响后代的后代，相关的研究结果发表在 American Journal of Stem Cells，杂志上，例如，即使母亲从来不喝酒，新生儿也有可能被诊断出胎儿酒精谱系障碍(FASD)，75%患有FASD的孩子的父亲都有酗酒的习惯，这表明父亲饮酒会对后代产生负面的影响。

该报道对至今为止关于父亲与遗传性表观遗传调控之间关联性的研究论文进行了总结，可概括为以下几点

1）父亲高龄会增加后代精神分裂症、自闭症和出生缺陷的发生率；

2）父亲童年时期限制饮食能降低孩子和孙子心血管疾病相关的死亡风险；

3）父亲肥胖会导致后代脂肪细胞体积的增大，代谢调控的改变及糖尿病、肥胖和脑癌的发生；

4）父亲的心理压力会引起后代行为特征的缺陷；

5）父亲饮酒会导致新生儿体重下降、大脑体积显着下降和认知功能受损。

最后，Kitlinska 讲到"父亲遗传性的表观遗传特征需要被整合到临床应用中，指导和改变人们的生活方式"。此外，Kitlinska还提到为真正理解表观遗传对孩子的影响，我们需要研究母亲和父亲这两个影响力的交互作用，而不是单独地、分离地去理解这两个影响因素。

原始出处

Review finds fathers' age， lifestyle associated with birth defects

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2017-04-14 维他命

#CEL#

48 0
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2016-09-01 zhaozhouchifen

#Cell#

75 0
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2016-07-13 hb2008ye

#stem cell#

62 0
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2017-05-08 yykkxiaodou

#stem cells#

66 0
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2016-05-25 12498bb3m92(暂无昵称)

#STEM#

74 0
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2016-05-25 kkunny

#健康状况#

59 0
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2016-05-25 124988c7m101暂无昵称

#cells#

66 0

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