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Neurology:隐源性卒中,应警惕非狭窄性颈动脉斑块

2016-10-25 MedSci MedSci原创

目的:要确定主要发生在单侧而非对侧较大的(≥3毫米厚)而非狭窄(<50%)颈动脉粥样斑块导致隐源性卒中。方法:这是一个横断面观察研究。采用脑卒中登记记录,研究者识别原因不明的前循环脑栓塞(ESUS)。利用CT血管成像,研究者测量每位患者颈动脉斑块的大小(厚度,mm)和颈动脉狭窄(北美症状性颈动脉内膜切除术试验法)。研究者将斑块大小按照预定义的阈值进行分类,计算每个阈值内同侧vs对侧卒中发生的频率。

目的:要确定主要发生在单侧而非对侧较大的(≥3毫米厚)而非狭窄(<50%)颈动脉粥样斑块导致隐源性卒中

方法:这是一个横断面观察研究。采用脑卒中登记记录,研究者识别原因不明的前循环脑栓塞(ESUS)。利用CT血管成像,研究者测量每位患者颈动脉斑块的大小(厚度,mm)和颈动脉狭窄(北美症状性颈动脉内膜切除术试验法)。研究者将斑块大小按照预定义的阈值进行分类,计算每个阈值内同侧vs对侧卒中发生的频率。

结果:研究者纳入了85例ESUS。11%的卒中患者同侧斑块厚度≥5毫米, 1%的卒中患者为对侧(9 / 85和1 / 85;P = 0.008)。19%的卒中患者同侧斑块厚度≥4毫米, 5%的卒中患者为对侧(16 / 85和4 / 85;P = 0.002)。35%的卒中患者同侧斑块厚度≥3毫米,15 %的卒中患者为对侧(30 / 85和13 / 85;P = 0.001)。同侧vs对侧脑卒中患者狭窄的百分比无显著性差异(P = 0.98),斑块大小与狭窄程度相关性较弱(R(2)= 0.26,P<0.001)。

结论:大而非狭窄的颈动脉斑块是导致患侧而非对侧隐源性卒中的常见因素,这表明非狭窄性的斑块是卒中未被重视的因素。研究者应用CT血管造影测得斑块大小,可以很容易地临床实践中应用。

原始出处:

Coutinho JM, Derkatch S, et al. Nonstenotic carotid plaque on CT angiography in patients with cryptogenic stroke. Neurology. 2016 Aug 16.


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    2017-04-04 yinhl1978
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    2016-10-28 1e1263e3m20(暂无匿称)

    学习了,多谢分享

    0

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