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Brit J Cancer:常用药物与子宫内膜癌生存率

2017-07-10 zhangfan MedSci原创

在子宫内膜癌确诊后服用他汀类药物、β阻断剂以及阿司匹林等常用药不会影响患者的生存率

随着药物新适应症的批准,子宫内膜癌(EC)患者的生存期逐渐延长,这种情况下,常用药物对于子宫内膜癌新辅助化疗的疗效影响的确证工作越发重要。

近日研究人员利用英国临床实践研究数据库、国家癌症研究数据库和国家统计办公室的死亡登记纪录,对1998-2010年间,新诊断的3058名子宫内膜癌患者进行前瞻性队列研究。利用Cox回归模型,调整前后的风险比(HR)和95%可信区间计算子宫内膜癌特异性生存率。

研究平均随访6.1年(范围1-16年),共发生394起特异性死亡事件。无论是否调整混杂因素,诊断后使用他汀类药物(aHR 0.83, 95% CI 0.64-1.08), β阻断剂(aHR 0.86, 95% CI 0.65-1.13)以及低剂量的阿司匹林(aHR 0.91, 95% CI 0.69- 1.20)不会显著影响子宫内膜癌患者生存率。药物治疗与子宫内膜癌特异性生存率之间不存在剂量效应相关性证据。

研究表明,在子宫内膜癌确诊后服用他汀类药物、β阻断剂以及阿司匹林等常用药不会影响患者的生存率。

原始出处:


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    2017-07-11 ylzr123

    认真学习,不断进步,把经验分享给同好。点赞了!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2085388, encodeId=ffaf2085388ed, content=<a href='/topic/show?id=70f14863158' target=_blank style='color:#2F92EE;'>#常用药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48631, encryptionId=70f14863158, topicName=常用药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sun Mar 11 14:18:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1708397, encodeId=13c41e08397c2, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Wed Apr 18 21:18:00 CST 2018, time=2018-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256580, encodeId=ed271256580e1, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Wed Jul 12 05:18:00 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1619195, encodeId=7e68161919580, content=<a href='/topic/show?id=049148630cb' target=_blank style='color:#2F92EE;'>#常用药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48630, encryptionId=049148630cb, topicName=常用药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Wed Jul 12 05:18:00 CST 2017, time=2017-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220855, encodeId=b2bf220855c8, content=认真学习,不断进步,把经验分享给同好。点赞了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Jul 11 06:38:47 CST 2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=220784, encodeId=5468220e84fa, content=讲解的非常好,值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Jul 10 19:14:20 CST 2017, time=2017-07-10, status=1, ipAttribution=)]
    2017-07-10 虈亣靌

    讲解的非常好,值得学习

    0

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