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重复 Allergy:变应原免疫治疗过敏性鼻结膜炎经济又有效!

2017-12-26 徐晓涵 环球医学

2017年发表在《Allergy》上的一项系统性评价和meta分析,对变应原免疫治疗(AIT)在过敏性鼻结膜炎管理中的有效性、成本效果以及安全性进行了评估。

2017年发表在《Allergy》上的一项系统性评价和meta分析,对变应原免疫治疗(AIT)在过敏性鼻结膜炎管理中的有效性、成本效果以及安全性进行了评估。

背景:欧洲变应性反应与临床免疫学学会(EAACI)正在制定AIT过敏性鼻结膜炎的指南。为了制定临床建议,研究人员进行了一项系统评价,旨在评估AIT在过敏性鼻结膜炎管理中的有效性、成本效果以及安全性。

方法:研究人员检索了9个国际生物医学数据库,检索内容为发表的、将要发表和未发表的证据。两名审查者按照预先定义的入组标准独立筛选了研究。首要结局为症状、药物、以及并发症和药物组合评分。次要结局包括成本效果和安全性。研究人员对数据进行了描述性总结,然后使用随机效应meta分析进行定量分析。

结果:研究人员鉴别出5960项研究,其中的160项研究符合入组标准。大量证据证实,在治疗时,症状(SMD,-0.53;95% CI,-0.63~-0.42)、药物(-0.37;-0.49~-0.26)、并发症和药物组合评分(-0.49;-0.69~-0.30)的标准平均差(SMD)显着性降低,敏感性分析中,结果一致。相比之下,更适度的证据关于AIT停药后有效性,表明了相关症状评分的获益。

结论:AIT对过敏性鼻结膜炎患者的症状改善、药物治疗、并发症与药物评分有利。部分证据表明停止治疗后仍有益处。

原始出处:
Dhami S, Nurmatov U, Arasi S, et al.Allergen immunotherapy for allergic rhinoconjunctivitis: A systematic review and meta-analysis.Allergy. 2017 Nov;72(11):1597-1631. doi: 10.1111/all.13201. Epub 2017 Jul 14.

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    2017-12-30 明崖

    学习了分享好成果

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2046921, encodeId=0ec920469210a, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sat Sep 22 04:00:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1677492, encodeId=807816e7492b0, content=<a href='/topic/show?id=2ebbe881920' target=_blank style='color:#2F92EE;'>#结膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78819, encryptionId=2ebbe881920, topicName=结膜炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=803827523485, createdName=tm10051990, createdTime=Tue Jan 16 14:00:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1940990, encodeId=ee31194099098, content=<a href='/topic/show?id=72711035025a' target=_blank style='color:#2F92EE;'>#鼻结膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103502, encryptionId=72711035025a, topicName=鼻结膜炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b30126, createdName=skhzy, createdTime=Sun Mar 04 22:00:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273921, encodeId=1eca2e39217f, content=学习了分享好成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Sat Dec 30 20:07:14 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329054, encodeId=9a2c1329054c4, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Thu Dec 28 13:00:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272801, encodeId=18f72e2801c3, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Wed Dec 27 00:19:01 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272787, encodeId=3f692e278772, content=2017年发表在<Allergy>上的一项系统性评价和meta分析.对变应原免疫治疗(AIT)在过敏性鼻结膜炎管理中的有效性.成本效果以及安全性进行了评估., beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue Dec 26 23:10:06 CST 2017, time=2017-12-26, status=1, ipAttribution=)]
    2017-12-28 膀胱癌
  6. [GetPortalCommentsPageByObjectIdResponse(id=2046921, encodeId=0ec920469210a, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sat Sep 22 04:00:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1677492, encodeId=807816e7492b0, content=<a href='/topic/show?id=2ebbe881920' target=_blank style='color:#2F92EE;'>#结膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78819, encryptionId=2ebbe881920, topicName=结膜炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=803827523485, createdName=tm10051990, createdTime=Tue Jan 16 14:00:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1940990, encodeId=ee31194099098, content=<a href='/topic/show?id=72711035025a' target=_blank style='color:#2F92EE;'>#鼻结膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103502, encryptionId=72711035025a, topicName=鼻结膜炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b30126, createdName=skhzy, createdTime=Sun Mar 04 22:00:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273921, encodeId=1eca2e39217f, content=学习了分享好成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Sat Dec 30 20:07:14 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329054, encodeId=9a2c1329054c4, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Thu Dec 28 13:00:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272801, encodeId=18f72e2801c3, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Wed Dec 27 00:19:01 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272787, encodeId=3f692e278772, content=2017年发表在<Allergy>上的一项系统性评价和meta分析.对变应原免疫治疗(AIT)在过敏性鼻结膜炎管理中的有效性.成本效果以及安全性进行了评估., beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue Dec 26 23:10:06 CST 2017, time=2017-12-26, status=1, ipAttribution=)]
    2017-12-27 杨利洪

    学习了分享了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2046921, encodeId=0ec920469210a, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, createdName=hongbochen, createdTime=Sat Sep 22 04:00:00 CST 2018, time=2018-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1677492, encodeId=807816e7492b0, content=<a href='/topic/show?id=2ebbe881920' target=_blank style='color:#2F92EE;'>#结膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78819, encryptionId=2ebbe881920, topicName=结膜炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=803827523485, createdName=tm10051990, createdTime=Tue Jan 16 14:00:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1940990, encodeId=ee31194099098, content=<a href='/topic/show?id=72711035025a' target=_blank style='color:#2F92EE;'>#鼻结膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103502, encryptionId=72711035025a, topicName=鼻结膜炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9b30126, createdName=skhzy, createdTime=Sun Mar 04 22:00:00 CST 2018, time=2018-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273921, encodeId=1eca2e39217f, content=学习了分享好成果, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Sat Dec 30 20:07:14 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329054, encodeId=9a2c1329054c4, content=<a href='/topic/show?id=bb96232801' target=_blank style='color:#2F92EE;'>#ALL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2328, encryptionId=bb96232801, topicName=ALL)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Thu Dec 28 13:00:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272801, encodeId=18f72e2801c3, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/21/39b6a0099eb602e8ac1f7e10d5d440a9.jpg, createdBy=dee01724555, createdName=杨利洪, createdTime=Wed Dec 27 00:19:01 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272787, encodeId=3f692e278772, content=2017年发表在<Allergy>上的一项系统性评价和meta分析.对变应原免疫治疗(AIT)在过敏性鼻结膜炎管理中的有效性.成本效果以及安全性进行了评估., beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue Dec 26 23:10:06 CST 2017, time=2017-12-26, status=1, ipAttribution=)]
    2017-12-26 有备才能无患

    2017年发表在上的一项系统性评价和meta分析.对变应原免疫治疗(AIT)在过敏性鼻结膜炎管理中的有效性.成本效果以及安全性进行了评估.

    0

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