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腹膜假性黏液瘤误诊为肝硬化腹水2例

2018-03-11 佚名 临床肝胆病杂志

患者女性,80岁

病例1

【一般资料】

患者女性,80岁

【主诉】

因“腹胀1个月余”,经门诊以“肝硬化腹水”收住院。

【既往史】

13岁时曾患肺结核,应用链霉素、异烟肼治疗,胸部X线提示病灶已钙化,否认肝病病史。

【体格检查】

皮肤黏膜未见黄染及出血点,无肝掌、蜘蛛痣,心肺未见异常,腹部高度膨隆,肝脾肋下未触及,移动性浊音可疑阳性,双下肢无凹陷性水肿。

【辅助检查】

白细胞计数(WBC)4.22×109/L,中性粒细胞百分比76.9%,红细胞计数(RBC)4.78×109/L,血红蛋白(Hb)110.00g/L,红细胞平均体积(MCV)77.20fl,平均红细胞血红蛋白量(MCH)22.90pg,红细胞平均血红蛋白浓度(MCHC)297.00g/L,血小板计数(PLT)314.00×109/L。肝功能:丙氨酸氨基转移酶(ALT)4.70U/L,天冬氨酸氨基转移酶(AST)12.90U/L,总胆红素(TBil)10.20μmol/L,直接胆红素(DBil)1.60μmol/L,间接胆红素(IBil)8.60μmol/L,血清白蛋白(Alb)39.60g/L,白球比(A/G)1.115,前白蛋白(PA)102.00mg/L。凝血功能:国际标准化比值(INR)1.11,凝血酶原活动度(PTA)85.0%,活化部分凝血活酶时间(APTT)46.3s,纤维蛋白原(Fib)6.86g/L。HBV血清学标志物,铜蓝蛋白,甲状腺功能,甲、戊、丙、丁型肝炎抗体,自身免疫性肝病相关自身抗体检测阴性。肿瘤标志物:糖链抗原(CA)12-540.12U/ml,CA19-9149.52U/ml,CA24-261.45kU/L,癌胚抗原(CEA)48.57ng/ml。腹水生化:蛋白定量(TP)25.84g/L。腹水常规:黄色、浑浊、有凝块,蛋白质阳性(﹢),比重1.020,细胞总数7840×106/L,有核细胞数642×106/L,单个核细胞42%,多个核细胞58%,未找到抗酸杆菌。腹部增强CT(图1)提示:肝硬化并大量腹水,腹膜增厚;直肠壁增厚。PET/CT示:(1)回盲部占位,呈边缘代谢性增高,考虑原发性病变,倾向黏液性肿瘤;(2)腹部不均匀增厚,局部形成多发结节,代谢增高,倾向转移。腹水脱落细胞检查:见大量无结构物,成堆及散在间皮细胞,少量中性粒细胞及淋巴细胞,未见恶性细胞。



病例2

【一般资料】

患者女性,62岁

【主诉】

因“反复腹胀、腹痛2个月余”于当地医院诊断为“肝硬化失代偿期”,经利尿、抗感染治疗10d后症状无好转,继而就诊本院,门诊以“肝硬化腹水”收治入院。

【既往史】

否认肝病及结核病史。

【体格检查】

皮肤黏膜未见黄染及出血点,无肝掌、蜘蛛痣,心肺未见异常,腹部膨隆,脐周压痛、反跳痛,肝脾肋下未触及,移动性浊音可疑阳性,双下肢无凹陷性水肿。

【辅助检查】

血常规:WBC4.12×109/L,RBC3.32×109/L,Hb86g/L,红细胞比容(HCT)27.9%,MCH26pg,MCHC311g/L,PLT198×109/L。肝功能:ALT19.98U/L,AST71.83U/L,TBil4.82μmol/L,DBil1.86μmol/L,IBil2.96μmol/L,Alb35.00g/L,A/G1.030,PA128.77mg/L。凝血功能:INR0.96,PT107%,Fib480g/L。抗-HBc阳性。铜蓝蛋白,甲状腺功能,甲、戊、丙、丁型肝炎抗体,自身免疫性肝病相关自身抗体检测阴性。腹部CT示:腹盆腔大量积液并肝周、腹膜及盆腔絮状、团状影,疑肿瘤性病变,建议腹水细胞学及生化检查;符合肝硬化失代偿期CT征象,脾脏多发囊状病灶,淋巴瘤待排除(图2)。多肿瘤标志物:CA12-555.75U/ml,CA19-985.84U/ml,CA24-245.98kU/L,CEA112.20ng/ml,铁蛋白377.03ng/ml。腹水生化:氯化物138.33mmol/L,乳酸脱氢酶69.82U/L,淀粉酶17.19U/L,腺苷脱氨酶4.360mmol/L,TP11.83g/L。浆膜腔积液常规+抗酸染色:蛋白质阳性(﹢),比重1.010,细胞总数2000×106/L,有核细胞70×106/L,单核细胞20%,多个核细胞80%。腹水脱落细胞学:见较多间皮细胞及无结构物,少量中性粒细胞及淋巴细胞,未见恶性细胞。


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    2018-06-30 gdsun
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    2018-03-13 121832a9m88暂无昵称

    学习了

    0

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    2018-03-13 xuyong530
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    2018-03-12 秀红

    学习了

    0

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    2018-03-11 cscdliu

    学习了.谢谢

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1933178, encodeId=7fb619331e8d2, content=<a href='/topic/show?id=4c371032459b' target=_blank style='color:#2F92EE;'>#黏液瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103245, encryptionId=4c371032459b, topicName=黏液瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ed25376, createdName=gdsun, createdTime=Sat Jun 30 18:59:00 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295686, encodeId=f91829568625, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Tue Mar 13 05:57:56 CST 2018, time=2018-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331263, encodeId=dc8f133126301, content=<a href='/topic/show?id=b0eb81309bf' target=_blank style='color:#2F92EE;'>#肝硬化腹水#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81309, encryptionId=b0eb81309bf, topicName=肝硬化腹水)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6262500044, createdName=1249862am72(暂无昵称), createdTime=Tue Mar 13 01:59:00 CST 2018, time=2018-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623793, encodeId=e4c81623e93cd, content=<a href='/topic/show?id=16ba8564526' target=_blank style='color:#2F92EE;'>#腹膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85645, encryptionId=16ba8564526, topicName=腹膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e220615097, createdName=xuyong530, createdTime=Tue Mar 13 01:59:00 CST 2018, time=2018-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295367, encodeId=a62329536ea8, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Mon Mar 12 06:10:52 CST 2018, time=2018-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295234, encodeId=32342952341a, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Sun Mar 11 19:47:05 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295194, encodeId=03d62951949a, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Mar 11 13:40:09 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295176, encodeId=7a342951e60e, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 11 12:34:58 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295170, encodeId=c6922951e060, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Sun Mar 11 11:37:33 CST 2018, time=2018-03-11, status=1, ipAttribution=)]
    2018-03-11 131****1460

    学习了受益匪浅

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1933178, encodeId=7fb619331e8d2, content=<a href='/topic/show?id=4c371032459b' target=_blank style='color:#2F92EE;'>#黏液瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103245, encryptionId=4c371032459b, topicName=黏液瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ed25376, createdName=gdsun, createdTime=Sat Jun 30 18:59:00 CST 2018, time=2018-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295686, encodeId=f91829568625, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Tue Mar 13 05:57:56 CST 2018, time=2018-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331263, encodeId=dc8f133126301, content=<a href='/topic/show?id=b0eb81309bf' target=_blank style='color:#2F92EE;'>#肝硬化腹水#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81309, encryptionId=b0eb81309bf, topicName=肝硬化腹水)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c6262500044, createdName=1249862am72(暂无昵称), createdTime=Tue Mar 13 01:59:00 CST 2018, time=2018-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623793, encodeId=e4c81623e93cd, content=<a href='/topic/show?id=16ba8564526' target=_blank style='color:#2F92EE;'>#腹膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85645, encryptionId=16ba8564526, topicName=腹膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e220615097, createdName=xuyong530, createdTime=Tue Mar 13 01:59:00 CST 2018, time=2018-03-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295367, encodeId=a62329536ea8, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Mon Mar 12 06:10:52 CST 2018, time=2018-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295234, encodeId=32342952341a, content=学习了.谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Sun Mar 11 19:47:05 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295194, encodeId=03d62951949a, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Mar 11 13:40:09 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295176, encodeId=7a342951e60e, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 11 12:34:58 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295170, encodeId=c6922951e060, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Sun Mar 11 11:37:33 CST 2018, time=2018-03-11, status=1, ipAttribution=)]
    2018-03-11 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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    2018-03-11 九九消寒

    优质资源.共同学习

    0

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