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Diabetologia:轻度糖尿病及无视网膜病变的1型糖尿病患者视网膜氧气提取

2017-08-01 MedSci MedSci原创

近日,国际杂志 《Diabetologia》上在线发表一项关于轻度糖尿病及无视网膜病变的1型糖尿病患者视网膜氧气抽提的研究。研究的目的是比较没有或轻度非增殖性糖

近日,国际杂志 《Diabetologia》上在线发表一项关于轻度糖尿病及无视网膜病变的1糖尿病患者视网膜氧气抽提的研究。研究的目的是比较没有或轻度非增殖性糖尿病视网膜病变的糖尿病患者和健康年龄、性别匹配的志愿者的视网膜氧气提取。

该横断面研究中共纳入了241型糖尿病患者和24名健康年龄和性别匹配的志愿者。通过使用定制的双向多普勒光学相干断层扫描系统与使用光谱反射测量的氧饱和度测量相结合测量总视网膜血流量来测量视网膜氧提取。基于以前公布的数学模型,计算视网膜血管中的氧含量和总视网膜氧气提取。

糖尿病参与者的总视网膜血流量(46.4±7.4μl/ min)高于健康志愿者(40.4±5.3μl/ min, 组间p=0.002)。视网膜动脉中的氧含量在两组间相当,但与健康对照组相比,糖尿病患者(0.15±0.02mlO2/ ml)的视网膜静脉氧含量较高(0.13±0.02mlO2 / mlp<0.001)。因此,与健康志愿者相比,糖尿病患者的动静脉氧差异和总视网膜氧提取率降低(总视网膜氧提取1.40±0.44,分别为1.70±0.47μlO2 / minp= 0.03)。

研究人员数据表明与健康对照个体相比,没有或轻度糖尿病性视网膜病变的1型糖尿病患者的早期视网膜缺氧。需要进一步的研究,以充分了解该技术在风险分层和治疗监测中的潜力。

原始出处:

Klemens Fondi, Piotr A. Wozniak, Kinga Howorka,et al. T Retinal oxygen extraction in individuals with type 1 diabetes with no or mild diabetic retinopathy

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    2017-08-08 1e145228m78(暂无匿称)

    学习了,谢谢作:者分享!

    0

  5. 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    2017-08-05 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

  6. 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createdBy=a38f7243741, createdName=xue8604, createdTime=Thu Aug 03 11:31:00 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229321, encodeId=325a22932109, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Wed Aug 02 21:43:57 CST 2017, time=2017-08-02, status=1, ipAttribution=)]
    2017-08-04 ylzr123

    感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Aug 08 00:23:46 CST 2017, time=2017-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230485, encodeId=dc4e2304850b, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sat Aug 05 23:29:45 CST 2017, time=2017-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229841, encodeId=2efe22984119, content=感谢小编为我们准备了如此丰盛的精神大餐,同时也向作者致谢!认真学习了,点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Aug 04 06:50:08 CST 2017, time=2017-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269924, encodeId=95ef126992404, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Thu Aug 03 11:31:00 CST 2017, time=2017-08-03, status=1, ipAttribution=), 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createdBy=a38f7243741, createdName=xue8604, createdTime=Thu Aug 03 11:31:00 CST 2017, time=2017-08-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=229321, encodeId=325a22932109, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Wed Aug 02 21:43:57 CST 2017, time=2017-08-02, status=1, ipAttribution=)]
    2017-08-03 zutt
  8. 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  9. 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  10. 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    2017-08-02 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

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