Immunity：免疫检查点调节因子为肿瘤免疫治疗提供新靶点

2016-05-29 佚名生物谷

最近，美国科学家发现了一种新的免疫应答调控因子，在这篇发表在国际学术期刊Immunity上的文章中，研究人员还对于T细胞为何无法清除慢性感染，消除肿瘤细胞的原因进行了解读。这些研究发现为许多临床背景下的T细胞应答调节开辟了新的道路。   T细胞是负责识别并清除特异性入侵者的免疫细胞，它们的活性受到高度调控--来自其他细胞的信号会调节T细胞应答进而对抗病原体。但是有时候这些应

最近，美国科学家发现了一种新的免疫应答调控因子，在这篇发表在国际学术期刊Immunity上的文章中，研究人员还对于T细胞为何无法清除慢性感染，消除肿瘤细胞的原因进行了解读。这些研究发现为许多临床背景下的T细胞应答调节开辟了新的道路。

T细胞是负责识别并清除特异性入侵者的免疫细胞，它们的活性受到高度调控--来自其他细胞的信号会调节T细胞应答进而对抗病原体。但是有时候这些应答很快就会消失，比如慢性病毒感染或癌症都会通过诱导T细胞紊乱导致免疫应答受阻。

近来一些阻断免疫检查点的新型药物的出现为肺癌以及黑色素瘤等特定类型癌症的治疗提供了新的改进方法。免疫检查点的作用类似于T细胞的制动系统，能够限制免疫系统对自身健康细胞进行攻击，防止自身免疫疾病的发生。

在这项研究中，研究人员发现一种叫做PSGL-1的分子能够增加免疫检查点水平，进而抑制T细胞活性。当PSGL-1发生缺失，T细胞的制动系统解除，T细胞就能够保持活跃状态。他们利用PSGL-1无应答小鼠进行研究发现这些小鼠能够完全根除淋巴细胞性脉络丛脑膜炎病毒（LCMV）的感染，而在正常情况下LCMV感染会持续数月。

随后，研究人员又将黑色素瘤细胞注射到模型小鼠体内，观察这种免疫制动分子的缺失是否能够影响癌症发展，结果发现模型小鼠体内的肿瘤生长明显慢于正常小鼠，这表明PSGL-1对T细胞应答具有重要的调控作用。

研究人员表示，阻断PSGL-1或可增强机体对癌症以及慢性病毒感染的免疫应答，而激活PSGL-1则可以帮助抑制免疫应答，或可用于类风湿性关节炎，牛皮癣，多发性硬化以及系统性红斑狼疮等自身免疫疾病的治疗。目前许多药物公司对该分子表示出极大兴趣，希望进一步开发其在临床方面的应用。研究人员认为PSGL-1抑制剂将会成为癌症免疫治疗的新工具，为无法从其他检查点抑制剂获得治疗效果的病人带来新的福音。

原始出处

Roberto Tinoco1, 2, Florent Carrette1, Monique L. Barraza1, Dennis C. Otero1, Jonathan Maga?a1, Marcus W. Bosenberg3, Susan L. Swain4, Linda M. Bradley.PSGL-1 Is an Immune Checkpoint Regulator that Promotes T Cell Exhaustion.Immunity.2016

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2017-01-31 12498d2fm51(暂无昵称)

#Immunity#

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2017-02-13 liuli5079

#调节因子#

79 0
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2016-06-03 yde2801fm***3926(暂无匿称)

学习了，免疫治疗是新的治疗方向，值得深入学习

116 0
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2016-06-02 mym86538653

想看全文

115 0
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2016-06-02 mym86538653

思路不错新方向

150 0
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2016-05-31 lsndxfj

#新靶点#

56 0
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2016-05-31 ms5187542471278033

#免疫检查点#

50 0
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2016-05-30 lsblb

确实不错

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Immunity：免疫检查点调节因子为肿瘤免疫治疗提供新靶点

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