Eur Heart J：恩格列净对心力衰竭患者循环蛋白质组学的影响

2022-08-28 MedSci原创 MedSci原创

心力衰竭患者循环蛋白水平的变化与实验研究结果一致。实验研究表明，SGLT2抑制剂的作用可能与心脏和肾脏促进自噬流、营养剥夺信号传导和跨膜钠转运有关。

钠-葡萄糖共转运体2(SGLT2)抑制剂可改善不同患者群体的心血管结局，但其作用机制有待进一步研究。

近日，心血管领域权威杂志Eur Heart J上发表了一篇研究文章，研究人员采用大规模蛋白质组学方法探讨恩格列净对心力衰竭患者循环细胞内蛋白水平的影响。

研究人员使用OlinkExplore1536平台，在基线、第12周和第52周检测了1134名来自EMPEROR-Reduced和EMPEROR-Preserved研究的患者超过1250个循环蛋白。统计和生物信息分析确定了差异表达蛋白(恩格列净 vs 安慰剂)，然后将其与心脏和肾脏中已证实的生物作用联系起来。

在第12周，1283个蛋白中有32个达到了预定的差异表达阈值，即它们的水平变化≥10%，错误发现率<1%(恩格列净 vs 安慰剂)。其中，恩格列净治疗效果最好的有9个蛋白:胰岛素样生长因子结合蛋白1、转铁蛋白受体蛋白1、碳酸酐酶2、促红细胞生成素、蛋白-谷氨酰胺-谷氨酰基转移酶2、胸腺肽β-10、u型线粒体肌酸激酶、胰岛素样生长因子结合蛋白4、脂肪细胞脂肪酸结合蛋白4。从基线到第52周的蛋白质变化与从基线到第12周的变化基本一致，除了恩格列净组肾损伤分子-1在第52周降低了10%以上，但在第12周没有降低。差异表达蛋白最常见的生物学作用是促进心脏、肾脏或内皮细胞的自噬流。差异表达蛋白对心脏的其他影响包括减少氧化应激、抑制炎症和纤维化、增强线粒体功能和提供能量、修复和再生能力。差异表达蛋白在肾脏中的作用涉及促进自噬、完整性和再生、抑制肾炎症和纤维化，以及调节肾小管钠的重吸收。

由此可见，心力衰竭患者循环蛋白水平的变化与实验研究结果一致。实验研究表明，SGLT2抑制剂的作用可能与心脏和肾脏促进自噬流、营养剥夺信号传导和跨膜钠转运有关。

原始出处：

Faiez Zannad,et al.Effect of Empagliflozin on Circulating Proteomics in Heart Failure: Mechanistic Insights from the EMPEROR Program.European Heart Journal.2022.https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehac495/6676779

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2023-06-05 1249842em19(暂无昵称)

#循环蛋白#

80 0
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2022-11-16 jjjiang0211

#蛋白质组#

92 0
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2023-02-02 柳叶一刀

#白质#

73 0
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2022-08-30 cmj8wellington

#蛋白质#

113 0
[GetPortalCommentsPageByObjectIdResponse(id=1706286, encodeId=30c41e0628629, content=<a href='/topic/show?id=e6f450461fd' target=_blank style='color:#2F92EE;'>#循环蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50461, encryptionId=e6f450461fd, topicName=循环蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffd131196023, createdName=1249842em19(暂无昵称), createdTime=Mon Jun 05 08:39:06 CST 2023, time=2023-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754888, encodeId=714d1e54888dd, content=<a href='/topic/show?id=0a1688e33b3' target=_blank style='color:#2F92EE;'>#蛋白质组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88733, encryptionId=0a1688e33b3, topicName=蛋白质组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cf6736789983, createdName=jjjiang0211, createdTime=Wed Nov 16 00:39:06 CST 2022, time=2022-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765996, encodeId=95a51e65996fd, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Thu Feb 02 03:39:06 CST 2023, time=2023-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297186, encodeId=7b09129e18658, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Aug 30 05:39:06 CST 2022, time=2022-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357975, encodeId=a706135e9757c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Aug 30 05:39:06 CST 2022, time=2022-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563657, encodeId=820c156365e2c, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Aug 30 05:39:06 CST 2022, time=2022-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1241728, encodeId=70ee1241e283d, content=<a href='/topic/show?id=1a17528644d' target=_blank style='color:#2F92EE;'>#恩格列净#</a>对<a href='/topic/show?id=072c5088466' target=_blank style='color:#2F92EE;'>#心力衰竭#</a>患者循环<a href='/topic/show?id=915d88e3471' target=_blank style='color:#2F92EE;'>#蛋白质组学#</a>，<a href='/topic/show?id=f5cb5192610' target=_blank style='color:#2F92EE;'>#心衰#</a>，不过这个机制也没有太大的用处，在临床上早已证实过了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52864, encryptionId=1a17528644d, topicName=恩格列净), TopicDto(id=50884, encryptionId=072c5088466, topicName=心力衰竭), TopicDto(id=88734, encryptionId=915d88e3471, topicName=蛋白质组学), TopicDto(id=51926, encryptionId=f5cb5192610, topicName=心衰)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Mon Aug 29 02:52:50 CST 2022, time=2022-08-29, status=1, ipAttribution=)]
2022-08-30 zhaojie88

#ART#

97 0
[GetPortalCommentsPageByObjectIdResponse(id=1706286, encodeId=30c41e0628629, content=<a href='/topic/show?id=e6f450461fd' target=_blank style='color:#2F92EE;'>#循环蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50461, encryptionId=e6f450461fd, topicName=循环蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffd131196023, createdName=1249842em19(暂无昵称), createdTime=Mon Jun 05 08:39:06 CST 2023, time=2023-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754888, encodeId=714d1e54888dd, content=<a href='/topic/show?id=0a1688e33b3' target=_blank style='color:#2F92EE;'>#蛋白质组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88733, encryptionId=0a1688e33b3, topicName=蛋白质组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cf6736789983, createdName=jjjiang0211, createdTime=Wed Nov 16 00:39:06 CST 2022, time=2022-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765996, encodeId=95a51e65996fd, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Thu Feb 02 03:39:06 CST 2023, time=2023-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297186, encodeId=7b09129e18658, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Aug 30 05:39:06 CST 2022, time=2022-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357975, encodeId=a706135e9757c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Aug 30 05:39:06 CST 2022, time=2022-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563657, encodeId=820c156365e2c, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Aug 30 05:39:06 CST 2022, time=2022-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1241728, encodeId=70ee1241e283d, content=<a href='/topic/show?id=1a17528644d' target=_blank style='color:#2F92EE;'>#恩格列净#</a>对<a href='/topic/show?id=072c5088466' target=_blank style='color:#2F92EE;'>#心力衰竭#</a>患者循环<a href='/topic/show?id=915d88e3471' target=_blank style='color:#2F92EE;'>#蛋白质组学#</a>，<a href='/topic/show?id=f5cb5192610' target=_blank style='color:#2F92EE;'>#心衰#</a>，不过这个机制也没有太大的用处，在临床上早已证实过了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52864, encryptionId=1a17528644d, topicName=恩格列净), TopicDto(id=50884, encryptionId=072c5088466, topicName=心力衰竭), TopicDto(id=88734, encryptionId=915d88e3471, topicName=蛋白质组学), TopicDto(id=51926, encryptionId=f5cb5192610, topicName=心衰)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Mon Aug 29 02:52:50 CST 2022, time=2022-08-29, status=1, ipAttribution=)]
2022-08-30 slcumt

#HEART#

134 0
[GetPortalCommentsPageByObjectIdResponse(id=1706286, encodeId=30c41e0628629, content=<a href='/topic/show?id=e6f450461fd' target=_blank style='color:#2F92EE;'>#循环蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50461, encryptionId=e6f450461fd, topicName=循环蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffd131196023, createdName=1249842em19(暂无昵称), createdTime=Mon Jun 05 08:39:06 CST 2023, time=2023-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1754888, encodeId=714d1e54888dd, content=<a href='/topic/show?id=0a1688e33b3' target=_blank style='color:#2F92EE;'>#蛋白质组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88733, encryptionId=0a1688e33b3, topicName=蛋白质组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cf6736789983, createdName=jjjiang0211, createdTime=Wed Nov 16 00:39:06 CST 2022, time=2022-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765996, encodeId=95a51e65996fd, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Thu Feb 02 03:39:06 CST 2023, time=2023-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1297186, encodeId=7b09129e18658, content=<a href='/topic/show?id=158288e017c' target=_blank style='color:#2F92EE;'>#蛋白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88701, encryptionId=158288e017c, topicName=蛋白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Tue Aug 30 05:39:06 CST 2022, time=2022-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357975, encodeId=a706135e9757c, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Aug 30 05:39:06 CST 2022, time=2022-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563657, encodeId=820c156365e2c, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue Aug 30 05:39:06 CST 2022, time=2022-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1241728, encodeId=70ee1241e283d, content=<a href='/topic/show?id=1a17528644d' target=_blank style='color:#2F92EE;'>#恩格列净#</a>对<a href='/topic/show?id=072c5088466' target=_blank style='color:#2F92EE;'>#心力衰竭#</a>患者循环<a href='/topic/show?id=915d88e3471' target=_blank style='color:#2F92EE;'>#蛋白质组学#</a>，<a href='/topic/show?id=f5cb5192610' target=_blank style='color:#2F92EE;'>#心衰#</a>，不过这个机制也没有太大的用处，在临床上早已证实过了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=156, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52864, encryptionId=1a17528644d, topicName=恩格列净), TopicDto(id=50884, encryptionId=072c5088466, topicName=心力衰竭), TopicDto(id=88734, encryptionId=915d88e3471, topicName=蛋白质组学), TopicDto(id=51926, encryptionId=f5cb5192610, topicName=心衰)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=循证小兵, createdTime=Mon Aug 29 02:52:50 CST 2022, time=2022-08-29, status=1, ipAttribution=)]
2022-08-29 循证小兵

#恩格列净#对#心力衰竭#患者循环#蛋白质组学#，#心衰#，不过这个机制也没有太大的用处，在临床上早已证实过了。

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