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Sci Rep:高盐饮食能促进自身免疫性疾病的进展

2016-06-28 MedSci MedSci原创

高盐饮食一直是饮食结构中的一个让人担忧的问题,而中国的传统食物如熏腊肉制品和腌制酱菜等都以高盐著称。高盐饮食被认为与高血压和肾脏疾病有关,然而近期研究发现其与自身免疫性疾病有着千丝万缕的关系。2016年6月23日,国际权威学术刊物、自然出版集团旗下子刊《Scientific Reports》杂志在线发表了中南大学湘雅二医院陆前进教授课题组题为:“High salt promotes autoimm

高盐饮食一直是饮食结构中的一个让人担忧的问题,而中国的传统食物如熏腊肉制品和腌制酱菜等都以高盐著称。高盐饮食被认为与高血压和肾脏疾病有关,然而近期研究发现其与自身免疫性疾病有着千丝万缕的关系。2016年6月23日,国际权威学术刊物、自然出版集团旗下子刊Scientific Reports杂志在线发表了中南大学湘雅二医院陆前进教授课题组题为:“High salt promotes autoimmunity by TET2-induced DNA demethylation and driving the differentiation of Tfh cells”的研究论文。助理研究员吴海竞博士、博士研究生黄馨和邱宏为论文并列第一作者,陆前进教授为论文通讯作者。该论文对高盐饮食与自身免疫性疾病系统性红斑狼疮之间的关联进行了深入研究。 系统性红斑狼疮(systemic lupus erythematosus, SLE)是一种多器官、多系统受累的自身免疫性疾病。其主要特征为产生大量的自身抗体,与抗原形成免疫复合物,在肾脏等多种组织器官沉积,进而引发炎症反应、造成组织器官损伤,甚至危及生命。SL

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1667680, encodeId=6546166e68074, content=<a href='/topic/show?id=ab7410252195' target=_blank style='color:#2F92EE;'>#高盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102521, encryptionId=ab7410252195, topicName=高盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b2526161022, createdName=lq1776, createdTime=Tue Nov 22 12:02:00 CST 2016, time=2016-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=126614, encodeId=89b9126614d1, content=赞一个!好文章拜读了,认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 14 13:24:00 CST 2016, time=2016-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580115, encodeId=ea891580115c0, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Thu Jun 30 14:02:00 CST 2016, time=2016-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629955, encodeId=52f31629955c9, content=<a href='/topic/show?id=cfc2102524b2' target=_blank style='color:#2F92EE;'>#高盐饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102524, encryptionId=cfc2102524b2, topicName=高盐饮食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded321409867, createdName=珙桐, createdTime=Thu Jun 30 14:02:00 CST 2016, time=2016-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91552, encodeId=bc7f9155207, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed Jun 29 09:22:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91551, encodeId=1b7191551fa, content=的确不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed Jun 29 09:21:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91505, encodeId=2fbb9150519, content=看来少吃盐是正确的, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Wed Jun 29 05:02:00 CST 2016, time=2016-06-29, status=1, ipAttribution=)]
    2016-11-22 lq1776
  2. [GetPortalCommentsPageByObjectIdResponse(id=1667680, encodeId=6546166e68074, content=<a href='/topic/show?id=ab7410252195' target=_blank style='color:#2F92EE;'>#高盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102521, encryptionId=ab7410252195, topicName=高盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b2526161022, createdName=lq1776, createdTime=Tue Nov 22 12:02:00 CST 2016, time=2016-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=126614, encodeId=89b9126614d1, content=赞一个!好文章拜读了,认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 14 13:24:00 CST 2016, time=2016-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580115, encodeId=ea891580115c0, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Thu Jun 30 14:02:00 CST 2016, time=2016-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629955, encodeId=52f31629955c9, content=<a href='/topic/show?id=cfc2102524b2' target=_blank style='color:#2F92EE;'>#高盐饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102524, encryptionId=cfc2102524b2, topicName=高盐饮食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded321409867, createdName=珙桐, createdTime=Thu Jun 30 14:02:00 CST 2016, time=2016-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91552, encodeId=bc7f9155207, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed Jun 29 09:22:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91551, encodeId=1b7191551fa, content=的确不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed Jun 29 09:21:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91505, encodeId=2fbb9150519, content=看来少吃盐是正确的, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Wed Jun 29 05:02:00 CST 2016, time=2016-06-29, status=1, ipAttribution=)]
    2016-09-14 ylzr123

    赞一个!好文章拜读了,认真学习了。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1667680, encodeId=6546166e68074, content=<a href='/topic/show?id=ab7410252195' target=_blank style='color:#2F92EE;'>#高盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102521, encryptionId=ab7410252195, topicName=高盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b2526161022, createdName=lq1776, createdTime=Tue Nov 22 12:02:00 CST 2016, time=2016-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=126614, encodeId=89b9126614d1, content=赞一个!好文章拜读了,认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 14 13:24:00 CST 2016, time=2016-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580115, encodeId=ea891580115c0, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Thu Jun 30 14:02:00 CST 2016, time=2016-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629955, encodeId=52f31629955c9, content=<a href='/topic/show?id=cfc2102524b2' target=_blank style='color:#2F92EE;'>#高盐饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102524, encryptionId=cfc2102524b2, topicName=高盐饮食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded321409867, createdName=珙桐, createdTime=Thu Jun 30 14:02:00 CST 2016, time=2016-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91552, encodeId=bc7f9155207, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed Jun 29 09:22:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91551, encodeId=1b7191551fa, content=的确不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed Jun 29 09:21:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91505, encodeId=2fbb9150519, content=看来少吃盐是正确的, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Wed Jun 29 05:02:00 CST 2016, time=2016-06-29, status=1, ipAttribution=)]
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1667680, encodeId=6546166e68074, content=<a href='/topic/show?id=ab7410252195' target=_blank style='color:#2F92EE;'>#高盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102521, encryptionId=ab7410252195, topicName=高盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b2526161022, createdName=lq1776, createdTime=Tue Nov 22 12:02:00 CST 2016, time=2016-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=126614, encodeId=89b9126614d1, content=赞一个!好文章拜读了,认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 14 13:24:00 CST 2016, time=2016-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580115, encodeId=ea891580115c0, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Thu Jun 30 14:02:00 CST 2016, time=2016-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629955, encodeId=52f31629955c9, content=<a href='/topic/show?id=cfc2102524b2' target=_blank style='color:#2F92EE;'>#高盐饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102524, encryptionId=cfc2102524b2, topicName=高盐饮食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded321409867, createdName=珙桐, createdTime=Thu Jun 30 14:02:00 CST 2016, time=2016-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91552, encodeId=bc7f9155207, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed Jun 29 09:22:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91551, encodeId=1b7191551fa, content=的确不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed Jun 29 09:21:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91505, encodeId=2fbb9150519, content=看来少吃盐是正确的, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Wed Jun 29 05:02:00 CST 2016, time=2016-06-29, status=1, ipAttribution=)]
    2016-06-29 milkshark

    值得学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1667680, encodeId=6546166e68074, content=<a href='/topic/show?id=ab7410252195' target=_blank style='color:#2F92EE;'>#高盐#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102521, encryptionId=ab7410252195, topicName=高盐)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b2526161022, createdName=lq1776, createdTime=Tue Nov 22 12:02:00 CST 2016, time=2016-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=126614, encodeId=89b9126614d1, content=赞一个!好文章拜读了,认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Sep 14 13:24:00 CST 2016, time=2016-09-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1580115, encodeId=ea891580115c0, content=<a href='/topic/show?id=bd2529020e1' target=_blank style='color:#2F92EE;'>#免疫性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29020, encryptionId=bd2529020e1, topicName=免疫性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=df0516593209, createdName=124988c7m100暂无昵称, createdTime=Thu Jun 30 14:02:00 CST 2016, time=2016-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629955, encodeId=52f31629955c9, content=<a href='/topic/show?id=cfc2102524b2' target=_blank style='color:#2F92EE;'>#高盐饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102524, encryptionId=cfc2102524b2, topicName=高盐饮食)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ded321409867, createdName=珙桐, createdTime=Thu Jun 30 14:02:00 CST 2016, time=2016-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91552, encodeId=bc7f9155207, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed Jun 29 09:22:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91551, encodeId=1b7191551fa, content=的确不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Wed Jun 29 09:21:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91505, encodeId=2fbb9150519, content=看来少吃盐是正确的, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2SEXGDldsNfP4rKvY7vJmaHcyvLXicuyaCTJtVOkX3jvd6DwNMD88hDjJwsU7MnUH6zeqC4zt3yGV/0, createdBy=4e701628585, createdName=flyingzyx, createdTime=Wed Jun 29 05:02:00 CST 2016, time=2016-06-29, status=1, ipAttribution=)]
    2016-06-29 milkshark

    的确不错

    0

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    2016-06-29 flyingzyx

    看来少吃盐是正确的

    0

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