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SJO：化疗会促进肿瘤进化

2015-12-03 佚名 生物谷

化疗乳腺癌肿瘤金华基因突变
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一项刊登于国际杂志Siberian Journal of Oncology上的研究论文中，来自俄罗斯的科学家通过研究发现，对乳腺癌患者进行辅助化疗或可刺激肿瘤发生进化；文章中研究人员对准备进行手术的乳腺癌患者的活组织样本进行了分析，随后在每一份样本的活组织检查中都检测到了染色体的异常情况。 在患者手术进行之前，患者接受了2-4小时的辅助化

图片来源：medicalxpress.com

近日，一项刊登于国际杂志Siberian Journal of Oncology上的研究论文中，来自俄罗斯的科学家通过研究发现，对乳腺癌患者进行辅助化疗或可刺激肿瘤发生进化；文章中研究人员对准备进行手术的乳腺癌患者的活组织样本进行了分析，随后在每一份样本的活组织检查中都检测到了染色体的异常情况。

在患者手术进行之前，患者接受了2-4小时的辅助化疗（neoadjuvant chemotherapy，NAC），术后研究者进行了重复的分析来观察肿瘤的治疗效应；结果研究者发现，在大部分患者机体中，化疗会完全或部分破坏肿瘤的老巢，但23%的患者却表现出了在辅助治疗情况下出现肿瘤新生的情况，而且研究者还在部分肿瘤细胞中发现了染色体的加倍现象，而肿瘤细胞也因此产生了耐药性，这种现象称之为放大效应，即化疗产生的副作用，计划所有的患者都发生了癌症转移，其余的患者在5年的观察期内并未发生肿瘤转移。

研究者Ibragimova表示，在化疗的影响下有可能会刺激耐药性肿瘤的进化，使其对当前化疗的效应并没有任何反应；前期实验结果表明，化疗会促进突变产生，而这些突变在染色体区域的放大效应中并没有发现，在某些病例中这或许是癌症血原性转移发生的主要原因；研究者希望可以发现参与肿瘤发生的方法和原因，然而毫无疑问的是化疗存在严格的个性化特征，这主要依赖于肿瘤和患者的特性。

大多数的化疗药物都是固有的突变剂，而化疗可以引发肿瘤细胞出现遗传异常，这些遗传异常就会导致肿瘤细胞的改变，因此研究者观察到的肿瘤细胞的死灰复燃就是为了应对化疗的攻击，目前研究者正在尝试揭示肿瘤为何会在化疗效应下进化以及其进化的机制。研究者后期将增加样本量来检查上述表现，如果可以利用一种技术成功预测特殊患者机体中的肿瘤发育，那么就可以确定是否患者需要进行化疗以及哪种药物可以被使用。

本文研究对于帮助制定乳腺癌患者的个体化治疗方案提供了一定思路，比如化疗目前是肿瘤学家们治疗肿瘤的主要手段，而他们希望后期可以开发出更多新型的癌症治疗手段。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=48971, encodeId=85cf489e12c, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48972, encodeId=cd2f489e27f, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44956, encodeId=728d44956b1, content=有点像人突破重重困难，突出重围一样。, beContent=null, objectType=article, channel=null, level=null, likeNumber=204, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44957, encodeId=4cdb4495ea6, content=生物进化论在这里也适用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44844, encodeId=933644844a1, content=相当于绞恐怖组织一样，相互增长的, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Dec 05 12:11:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44843, encodeId=5b054484303, content=不难理解！和放疗一样！, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Dec 05 11:48:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44780, encodeId=62c444e8053, content=肿瘤进化能力超强, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Dec 04 19:31:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44744, encodeId=675e44e44fc, content=同意其观点, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Dec 04 12:24:00 CST 2015, time=2015-12-04, status=1, ipAttribution=)]
    2015-12-27 hixiaoluo

    好文章，值得收藏

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=48971, encodeId=85cf489e12c, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48972, encodeId=cd2f489e27f, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44956, encodeId=728d44956b1, content=有点像人突破重重困难，突出重围一样。, beContent=null, objectType=article, channel=null, level=null, likeNumber=204, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44957, encodeId=4cdb4495ea6, content=生物进化论在这里也适用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44844, encodeId=933644844a1, content=相当于绞恐怖组织一样，相互增长的, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Dec 05 12:11:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44843, encodeId=5b054484303, content=不难理解！和放疗一样！, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Dec 05 11:48:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44780, encodeId=62c444e8053, content=肿瘤进化能力超强, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Dec 04 19:31:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44744, encodeId=675e44e44fc, content=同意其观点, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Dec 04 12:24:00 CST 2015, time=2015-12-04, status=1, ipAttribution=)]
    2015-12-27 hixiaoluo

    好文章，值得收藏

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=48971, encodeId=85cf489e12c, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48972, encodeId=cd2f489e27f, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44956, encodeId=728d44956b1, content=有点像人突破重重困难，突出重围一样。, beContent=null, objectType=article, channel=null, level=null, likeNumber=204, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44957, encodeId=4cdb4495ea6, content=生物进化论在这里也适用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44844, encodeId=933644844a1, content=相当于绞恐怖组织一样，相互增长的, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Dec 05 12:11:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44843, encodeId=5b054484303, content=不难理解！和放疗一样！, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Dec 05 11:48:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44780, encodeId=62c444e8053, content=肿瘤进化能力超强, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Dec 04 19:31:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44744, encodeId=675e44e44fc, content=同意其观点, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Dec 04 12:24:00 CST 2015, time=2015-12-04, status=1, ipAttribution=)]
    2015-12-06 三三五五

    有点像人突破重重困难，突出重围一样。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=48971, encodeId=85cf489e12c, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48972, encodeId=cd2f489e27f, content=好文章，值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 08:41:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44956, encodeId=728d44956b1, content=有点像人突破重重困难，突出重围一样。, beContent=null, objectType=article, channel=null, level=null, likeNumber=204, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44957, encodeId=4cdb4495ea6, content=生物进化论在这里也适用？, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Sun Dec 06 09:09:00 CST 2015, time=2015-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44844, encodeId=933644844a1, content=相当于绞恐怖组织一样，相互增长的, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Dec 05 12:11:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44843, encodeId=5b054484303, content=不难理解！和放疗一样！, beContent=null, objectType=article, channel=null, level=null, likeNumber=171, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170803/IMG5982F7A3DBB3C1061.jpg, createdBy=0ba51605600, createdName=Jianghuiqin, createdTime=Sat Dec 05 11:48:00 CST 2015, time=2015-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44780, encodeId=62c444e8053, content=肿瘤进化能力超强, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Fri Dec 04 19:31:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44744, encodeId=675e44e44fc, content=同意其观点, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Dec 04 12:24:00 CST 2015, time=2015-12-04, status=1, ipAttribution=)]
    2015-12-06 三三五五

    生物进化论在这里也适用？

    0

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    2015-12-05 lovetcm

    相当于绞恐怖组织一样，相互增长的

    0

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    2015-12-05 Jianghuiqin

    不难理解！和放疗一样！

    0

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    2015-12-04 medcardio

    肿瘤进化能力超强

    0

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    2015-12-04 老段

    同意其观点

    0

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