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Diabetes Care:妊娠期高血糖或可不能导致后代肥胖

2015-07-06 徐媛媛译 MedSci原创

已有研究称母亲在妊娠期间出现高血糖,其后代肥胖的风险高,但关于这个研究结论一直存在争议。本研究调查了母体妊娠期间高血糖和不良妊娠结局(HAPO)与后代5~7岁时人体测量学指标之前的相关性。 在妊娠28周时对所有女性(HAPO)进行75g口服葡萄糖耐量试验(OGTT)。收集5-7岁后代的体重、升高、皮褶厚度测量数据。基于1990年英国增长标准,超重、肥胖和极端肥胖被定义为体重指数BMI-Z分数分别

已有研究称母亲在妊娠期间出现高血糖,其后代肥胖的风险高,但关于这个研究结论一直存在争议。本研究调查了母体妊娠期间高血糖和不良妊娠结局(HAPO)与后代5~7岁时人体测量学指标之前的相关性。

在妊娠28周时对所有女性(HAPO)进行75g口服葡萄糖耐量试验(OGTT)。收集5-7岁后代的体重、升高、皮褶厚度测量数据。基于1990年英国增长标准,超重、肥胖和极端肥胖被定义为体重指数BMI-Z分数分别是≥85,≥95,和≥99百分位。

收纳了1320名年龄在5~7岁后代并进行随访。研究人员发现,母体空腹血糖、餐后1h后血糖、2h血糖与BMI的Z评分值或后代皮褶厚度总和之间没有相关性,独立于母体行OGTT时的BMI和后代出生体重的Z评分值。当不同性别的后代BMI-Z值≥85th、≥95th或99th百分位,皮褶厚度总和≥90th百分位时,其与母体血糖水平之间仍无相关性。

在母体进行OGTT时对BMI矫正后,母体在妊娠期间的高空腹血糖水平不再是后代肥胖的危险因素。

原始出处

Thaware PK1, McKenna S2, Patterson CC3, Hadden DR4, Pettitt DJ5, McCance DR6.Untreated Mild Hyperglycemia During Pregnancy and Anthropometric Measures of Obesity in Offspring at Age 5-7 Years.Diabetes Care. 2015 Jun 19

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objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160804/IMG57A2EF131ACE72300.jpg, createdBy=a2811610046, createdName=黄庆, createdTime=Mon Jul 06 15:11:00 CST 2015, time=2015-07-06, status=1, ipAttribution=)]
  5. 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objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160804/IMG57A2EF131ACE72300.jpg, createdBy=a2811610046, createdName=黄庆, createdTime=Mon Jul 06 15:11:00 CST 2015, time=2015-07-06, status=1, ipAttribution=)]
    2015-07-21 qingfengqishi5

    不错哦

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Jul 09 12:09:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31651, encodeId=97a431651a5, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed Jul 08 12:33:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250964, encodeId=0bd51250964ea, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Wed Jul 08 00:31:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1261070, encodeId=0fd912610e045, content=<a href='/topic/show?id=30c6102e2607' target=_blank style='color:#2F92EE;'>#高血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102726, encryptionId=30c6102e2607, topicName=高血糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Wed Jul 08 00:31:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30904, encodeId=c0753090499, content=确实是个明智的, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160804/IMG57A2EF131ACE72300.jpg, createdBy=a2811610046, createdName=黄庆, createdTime=Mon Jul 06 15:11:00 CST 2015, time=2015-07-06, status=1, ipAttribution=)]
    2015-07-09 cmn

    挺常见了

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Jul 09 12:09:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31651, encodeId=97a431651a5, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed Jul 08 12:33:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250964, encodeId=0bd51250964ea, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Wed Jul 08 00:31:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1261070, encodeId=0fd912610e045, content=<a href='/topic/show?id=30c6102e2607' target=_blank style='color:#2F92EE;'>#高血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102726, encryptionId=30c6102e2607, topicName=高血糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Wed Jul 08 00:31:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30904, encodeId=c0753090499, content=确实是个明智的, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160804/IMG57A2EF131ACE72300.jpg, createdBy=a2811610046, createdName=黄庆, createdTime=Mon Jul 06 15:11:00 CST 2015, time=2015-07-06, status=1, ipAttribution=)]
    2015-07-08 huaxipanxing

    看看

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Jul 09 12:09:00 CST 2015, time=2015-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31651, encodeId=97a431651a5, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=151, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed Jul 08 12:33:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250964, encodeId=0bd51250964ea, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, 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objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160804/IMG57A2EF131ACE72300.jpg, createdBy=a2811610046, createdName=黄庆, createdTime=Mon Jul 06 15:11:00 CST 2015, time=2015-07-06, status=1, ipAttribution=)]
  9. 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level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Wed Jul 08 00:31:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1261070, encodeId=0fd912610e045, content=<a href='/topic/show?id=30c6102e2607' target=_blank style='color:#2F92EE;'>#高血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102726, encryptionId=30c6102e2607, topicName=高血糖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Wed Jul 08 00:31:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30904, encodeId=c0753090499, content=确实是个明智的, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160804/IMG57A2EF131ACE72300.jpg, createdBy=a2811610046, createdName=黄庆, createdTime=Mon Jul 06 15:11:00 CST 2015, time=2015-07-06, status=1, ipAttribution=)]
    2015-07-08 hbwxf
  10. 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objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160804/IMG57A2EF131ACE72300.jpg, createdBy=a2811610046, createdName=黄庆, createdTime=Mon Jul 06 15:11:00 CST 2015, time=2015-07-06, status=1, ipAttribution=)]
    2015-07-06 黄庆

    确实是个明智的

    0

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