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JAHA:胶原标志物对射血分数降低和正常的心力衰竭预测价值如何?

2018-02-26 xing.T MedSci原创

由此可见,高水平的循环胶原生物标志物ICTP和PIIINP似乎与HFpEF发生有关,但与HFrEF无关。

胶原标志物可能与心力衰竭及其亚型有关。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章。研究人员假设循环III型前胶原N端肽(PIIINP)和I型胶原羧基末端肽(ICTP)可以预测心衰事件。

研究人员在一个多种族样本中采用分层抽样设计抽取了3187例初始年龄为45-84岁的无心血管疾病个体。研究人员采用采用放射免疫分析法检测了基线血清PIIINP和ICTP浓度。心衰事件被区分为射血分数降低(HFrEF;EF<45%)和EF正常(HFpEF;EF≥45%)两类。研究人员使用泊松回归模型计算PIIINP和ICTP每增加一个SD的HFpEF和HFrEF发病密度,在模型1中调整了年龄、种族、性别和肾功能,在模型2中调整了除这些因素外,还有血压以及药物。

受试者ICTP平均(SD)为3.38±1.77μg/L,PIIINP平均(SD)为5.48±2.04μg/L。HF病例中,96例HFrEF患者和107例HFpEF患者。研究人员发现PIIINP和ICTP都不能显著预测HFrEF事件。在模型1中,13年期间每100人HFpEF的发病密度在PIIINP较低和较高的个体中分别为1.65人和3人(P=0.002),在模型2中对应为1.45人和2.59人(P=0.003)。对于较低与较高的ICTP,在模型1中发病密度分别为1.79人和3.64人(P=0.002);在模型2中分别为1.58人和3.12人(P=0.002)。

由此可见,高水平的循环胶原生物标志物ICTP和PIIINP似乎与HFpEF发生有关,但与HFrEF无关。

原始出处:

Daniel A. Duprez,et al. Predictive Value of Collagen Biomarkers for Heart Failure With and Without Preserved Ejection Fraction: MESA (Multi‐Ethnic Study of Atherosclerosis).JAHA.2018. https://doi.org/10.1161/JAHA.117.007885

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    2018-02-28 zhaohui6731
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    2018-02-26 明月清辉

    谢谢分享.学习了

    0

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