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PNAS:单次催产素鼻腔喷雾或改善自闭症患儿脑功能

2013-12-09 高晓方 译 医学论坛网

      耶鲁大学医学院的研究者发现,在自闭症谱系疾病患儿中,单次催产素鼻腔喷雾可增强社交信息处理期间的脑活动。相关文章发表于12月的《美国国家科学院院刊》(PNAS)上。 此项双盲、安慰剂对照研究共纳入17例伴有自闭症谱系疾病的儿童和青少年(年龄8~16.5岁),并在涉及社交判断的任务期间随机给予催产素或安慰剂鼻腔喷雾。 结果显示,当患儿接受催产素鼻腔喷雾时,与奖

  

   

耶鲁大学医学院的研究者发现,在自闭症谱系疾病患儿中,单次催产素鼻腔喷雾可增强社交信息处理期间的脑活动。相关文章发表于12月的《美国国家科学院院刊》(PNAS)上。

此项双盲、安慰剂对照研究共纳入17例伴有自闭症谱系疾病的儿童和青少年(年龄8~16.5岁),并在涉及社交判断的任务期间随机给予催产素或安慰剂鼻腔喷雾。

结果显示,当患儿接受催产素鼻腔喷雾时,与奖赏和情绪识别相关的脑中枢对社交任务反应更为显著。催产素使导致社交困难的脑区暂时性正常化。此外,催产素使涉及社交行为和社交识别的脑区在应对社交刺激时更为活化,并在非社交刺激时活化减低。

英文链接:A single spray of C improves brain function in children with autism


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    2014-04-13 drwjr
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    2013-12-11 xiongke014
  6. [GetPortalCommentsPageByObjectIdResponse(id=1855470, encodeId=6ca818554e0ea, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Sun Apr 13 02:26:00 CST 2014, time=2014-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1994947, encodeId=2d92199494e54, content=<a href='/topic/show?id=eb8f10351e38' target=_blank style='color:#2F92EE;'>#鼻腔喷雾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103517, encryptionId=eb8f10351e38, topicName=鼻腔喷雾)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a19115, createdName=stfoxst, createdTime=Tue Jun 10 13:26:00 CST 2014, time=2014-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1442395, encodeId=04f61442395cd, content=<a href='/topic/show?id=dfae84e3003' target=_blank style='color:#2F92EE;'>#脑功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84730, encryptionId=dfae84e3003, topicName=脑功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00224929300, createdName=ms1467340776200723, createdTime=Wed Dec 11 07:26:00 CST 2013, time=2013-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1465812, encodeId=2972146581238, content=<a href='/topic/show?id=736b103508c6' target=_blank style='color:#2F92EE;'>#鼻腔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103508, encryptionId=736b103508c6, topicName=鼻腔)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Wed Dec 11 07:26:00 CST 2013, time=2013-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1527545, encodeId=e7b7152e545a8, content=<a href='/topic/show?id=68b5863e5d2' target=_blank style='color:#2F92EE;'>#自闭#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86375, encryptionId=68b5863e5d2, topicName=自闭)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=159511872623, createdName=xiongke014, createdTime=Wed Dec 11 07:26:00 CST 2013, time=2013-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529910, encodeId=bc8515299109c, content=<a href='/topic/show?id=010228026b8' target=_blank style='color:#2F92EE;'>#催产#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28026, encryptionId=010228026b8, topicName=催产)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f1711981795, createdName=zhanfl, createdTime=Wed Dec 11 07:26:00 CST 2013, time=2013-12-11, status=1, ipAttribution=)]
    2013-12-11 zhanfl
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