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Pediatr Infect Dis J:孕期接种流感疫苗可减低后代呼吸系统疾病风险

2016-07-12 zhaoshuang 译 MedSci原创

近期有研究称,母亲在怀孕期间接受流行性感冒病毒亚单位疫苗,其后代出生后与未接种母亲产下的后代相比,在生命的前6个月,在流感季节因急性呼吸道疾病住院的可能性更小。西澳大利亚大学病理及实验室的Annette K. Regan对31000对单胎母儿进行了研究,将孕期接种疫苗定义为分娩前至少14天接种流行性感冒病毒亚单位疫苗。研究中共有3169名孕妇接种疫苗,27589名未接种,其后代分别为疫苗组和对照组

近期有研究称,母亲在怀孕期间接受流行性感冒病毒亚单位疫苗,其后代出生后与未接种母亲产下的后代相比,在出生后6个月,在流感季节因急性呼吸道疾病住院的可能性更小。

西澳大利亚大学病理及实验室的Annette K. Regan对31000对单胎母儿进行了研究,将孕期接种疫苗定义为分娩前至少14天接种流行性感冒病毒亚单位疫苗。

研究中共有3169名孕妇接种疫苗,27589名未接种,其后代分别为疫苗组和对照组。研究者发现后代中共发生了732例住院,其中69%的为毛细支气管炎。疫苗组和对照组的住院率分别为21.9/100000和30.2/100000。

与对照组相比,疫苗组婴儿在流感季节因急性呼吸道疾病住院的可能性下降25%(aHR = 0.75, 95% CI, 0.56-0.99)。此外,研究者观察到,孕晚期接种疫苗可降低后代33%的住院风险(aHR = 0.67, 95% CI, 0.47-0.95),早期接种疫苗没有发现其他风险的降低。

研究结构表明,孕期接种流行性感冒病毒亚单位疫苗,可显著降低后代在出生后前6个月,在流感季节因急性呼吸道疾病住院的风险。

原始出处:


Regan AK, et al. Effect of Maternal Influenza Vaccination on Hospitalization for Respiratory Infections in Newborns: A Retrospective Cohort Study.Pediatr Infect Dis J. 2016;doi:10.1097/INF.0000000000001258.

Maternal influenza vaccination linked to reduced respiratory illness among infants
.Healio.July 11, 2016


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    2016-10-08 1e10c84am36(暂无匿称)

    文章很棒,继续学习

    0

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    2016-09-10 ylzr123

    认真学习。赞!好文待探究。

    0

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    2017-01-03 feather89
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