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JACN:乳制品可改善肝功能,抑制系统性炎症

2015-11-30 MedSci MedSci原创

每天食用三份乳制品可以改善代谢综合症患者肝功能,抑制系统性炎症。

目标:六周交叉研究设计,分析增加乳制品摄入量对通常很少消费乳制品的MetS(metabolic syndrome,代谢综合征)患者(n = 37)系统性炎症和肝酶的影响。

方法:随机化研究,在6周内试验期受试者食用LFD(low-fat dairy,低脂乳制品)(10盎司含脂1%牛奶,6盎司脱脂酸奶,4盎司含脂2%奶酪),控制期受试者食用CNT(
carbohydrate-based control ,碳水化合物)(1.5盎司格兰诺拉燕麦卷和12盎司100%果汁)。四周洗脱期之后,将受试者交叉互换。

评估炎症状态,测定空腹血浆CRP、TNF-α和MCP-1浓度。在每个饮食期终点,测定17例受试者(13例女性,3例男性)的外周血单核细胞中IL-1、IL-6和TNF-α的基因表达水平。检测肝酶,观察乳制品成分是否影响肝功能。

结果:在LFD期终点,受试者血浆ALT(P<0.05)和AST(P<0.005)浓度较低。对所有数据汇总分析发现受试者血浆炎症因子的改变没有显著性。

与控制期相比较,试验期受试者外周血单核细胞IL-1b和IL-6的表达分别减少了46%和63%。按性别分层时,LFD期女性受试者与CNT期相比较,空腹血浆TNF-α(P=0.028)和MCP-1(P=0.001)下降。LFD期终点时受试者肝脂肪变性指数评分显著降低(P<0.001)。


结论:每日三餐食用乳制品可以改善代谢综合症患者肝功能,抑制系统性炎症。

原始出处:

Christine E Dugan, David Aguilar, Young-Ki Park, et all. Dairy Consumption Lowers Systemic Inflammation and Liver Enzymes in Typically Low-Dairy Consumers with Clinical Characteristics of Metabolic Syndrome. Journal of the American College of Nutrition. Published online 23 Nov 2015. 

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2016926, encodeId=513d201692628, content=<a href='/topic/show?id=9760e69058c' target=_blank style='color:#2F92EE;'>#系统性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76905, encryptionId=9760e69058c, topicName=系统性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2b9b368, createdName=qingrejiedu, createdTime=Mon Oct 17 08:51:00 CST 2016, time=2016-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=50230, encodeId=02b750230ee, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Tue Dec 29 15:40:00 CST 2015, time=2015-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49772, encodeId=e46249e723c, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 02:01:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49770, encodeId=e4fc49e7056, content=不错哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 02:00:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49771, encodeId=83be49e71fc, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Mon Dec 28 02:00:00 CST 2015, time=2015-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366690, encodeId=ff12136669027, content=<a href='/topic/show?id=8b4181188f5' target=_blank style='color:#2F92EE;'>#肝功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81188, encryptionId=8b4181188f5, topicName=肝功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8942242, createdName=jj000001, createdTime=Wed Dec 02 11:51:00 CST 2015, time=2015-12-02, status=1, ipAttribution=)]
    2015-12-29 xyfg98

    0

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    2015-12-28 wzf990214

    赞一个

    0

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    2015-12-28 wzf990214

    不错哦

    0

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    2015-12-28 wzf990214

    有意思

    0

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