BMJ：抗抑郁药物的使用与自杀风险

2015-02-20 Mechront MedSci原创

抑郁症病人中有很高的自杀率，而对其治疗的关键问题之一是减少自杀率。目前临床上抗抑郁药物主要为三类：三环类抗抑郁药物、选择性5-羟色胺再摄取抑制剂SSRI、其他抗抑郁药物。Carol Coupland等人进行了一项队列研究，以探究抑郁人群中，不同抗抑郁药物的使用与自杀和尝试自杀或自我伤害发生率的联系。该研究纳入了2000-01-01到2011-06-31期间第一次诊断为抑郁症的患者，共23

抑郁症病人中有很高的自杀率，而对其治疗的关键问题之一是减少自杀率。目前临床上抗抑郁药物主要为三类：三环类抗抑郁药物、选择性5-羟色胺再摄取抑制剂SSRI、其他抗抑郁药物。Carol Coupland等人进行了一项队列研究，以探究抑郁人群中，不同抗抑郁药物的使用与自杀和尝试自杀或自我伤害发生率的联系。该研究纳入了2000-01-01到2011-06-31期间第一次诊断为抑郁症的患者，共238,963名，年龄范围20-64岁，研究者们最长随访其到2012-08-01。研究结果显示，87.7%（n=209,476）的患者接受了至少一次的抗抑郁药物处方。治疗持续时间中位数为221天（四分位范围 79-590天）。在第一个5年随访中，198例自杀，5243例尝试自杀或自身伤害。治疗期间，三环类抗抑郁药物相比SSRI对自杀风险没有统计学差异（aHR 0.84，95%CI 0.47-1.50）；其他类别抗抑郁药物使用时，自杀风险显著增加（aHR 2.64，95%CI 1.74-3.99）。米氮平与西酞普兰相比，其明显增加自杀风险（aHR&n

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2016-01-31 wetgdt

#抑郁药#

69 0
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2015-02-24 docwu2019

#自杀风险#

84 0
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2015-11-15 柳叶一刀

#BMJ#

78 0
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2015-02-22 huhuaidong389

#抗抑郁药物#

65 0
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2015-02-22 wushaoling

#抗抑郁#

81 0
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2015-02-21 222.209.146.**

SSRI…

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