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SCI REP:腹膜透析技术失败原因与全因死亡率之间的关系!

2018-03-05 xing.T MedSci原创

总之,感染和社会相关的技术故障与技术失败后2年内的过早死亡有关。评估这些相关性的未来研究可能有助于改善这些患者的预后。

技术失败是腹膜透析(PD)的常见并发症,但技术失败所致的死亡与死亡率之间的关系尚不清楚。近日,Scientific reports杂志上发表了一篇研究文章,以澳大利亚和新西兰透析和移植(ANZDATA)登记中心的数据,研究人员在1989年-2014年期间所有经历过技术失败的PD患者中评估技术故障原因与死亡率之间的关联。

在4663例患者中,2415例患者因感染而失败,883例透析不充分,836例机械故障,529例为社会原因。

感染相比,透析前2年全因死亡率的调整危险比(HR)在透析不充分的患者中为0.83(95% CI 0.70 - 0.98),在机械故障的患者中为0.78(95% CI 0.66 - 0.93),在社会原因的患者中为1.46(95% CI 1.24 - 1.72)。竞争风险模型的估计是相似的。年龄和技术故障之间存在相互作用(相互作用P<0.001),在年龄>60岁的发生社会相关技术故障的老年人中过早死亡最为显著。技术失败的原因与2年后的死亡率之间没有相关性。

总之,感染和社会相关的技术故障与技术失败后2年内的过早死亡有关。评估这些相关性的未来研究可能有助于改善这些患者的预后。

原始出处:


Jenny H. C. Chen,et al. Association between causes of peritoneal dialysis technique failure and all-cause mortality.Scientific reports.2018. https://www.nature.com/articles/s41598-018-22335-4

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    2018-03-07 xuyong530
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    2018-03-05 1e160a78m83(暂无匿称)

    腹膜透析技术在北方开展的还不算好

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