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JACC:慢性心力衰竭及房颤患者的运动训练

2017-04-04 MedSci MedSci原创

伴有AF的慢性心衰患者年龄偏大,基线运动能力降低,临床事件发生率高,但是其对运动训练的结果及运动能力变化的反应并没有不同。

近日血管权威杂志Journal of the American College of Cardiology上发表了一篇研究文章,旨在探讨心衰伴有房颤(AF)患者运动训练的结果是否和AF状态有关。

研究人员选取了2,331例射血分数≤35%的心衰患者,并随机分为运动训练组和常规护理组。采用调整后的Cox模型通过基线AF状态(既往有AF病史、AF在心电图基线或无AF)分析心衰患者的临床特征和结局(死亡/住院)与运动训练的关系。并且评价了因AF住院而后诊断的随机AF事件,以及AF相关严重心律失常报告。

在2,292例有基线心律的心衰患者中,382例(17%)有AF,1,602例(70%)为窦性心律,308例(13%)有"其他"节律。AF患者年龄较大,峰值摄氧量VO2较低。在随访的2.6年中,未经调整的分析显示每年AF心衰患者死亡率/住院率高24%(风险比[HR]:1.53;95%置信区间[CI]:1.34-1.74;P<0.001);调整后差异不再显着(HR:1.15;95%CI:0.98-1.35; P=0.09)。按治疗随机分组或按基线AF状态随机分组的AF事件发生率并无显着差异(P均>0.10)。AF和运动训练在功能状态或临床结果的评价中没有相互作用(P均> 0.10)。

由此可见,伴有AF的慢性心衰患者年龄偏大,基线运动能力降低,临床事件发生率高,但是其对运动训练的结果及运动能力变化的反应并没有不同。

原始出处:

Nancy Luo, Peter Merrill, Kishan S. Parikh, et al. Exercise Training in Patients With Chronic Heart Failure and Atrial Fibrillation.  JACC. 4 April 2017.

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    2017-07-26 hbwxf
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