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CIRC RES：冠心病患者7-酮基胆固醇与心血管预后和总死亡相关！

2017-04-06 xing.T MedSci原创

7-KC冠心病预后死亡率
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由此可见，7-KC水平升高与稳定型CAD患者心血管事件、总死亡和复合结局风险增加相关。


7-酮基胆固醇（7-KC），是一种胆固醇的氧化产物，在动物模型的动脉粥样硬化形成上发挥重要作用。近日，心血管领域权威杂志Circulation Research上发表了一篇研究文章，研究人员试图明确循环中7-KC与稳定型冠心病（CAD）患者的临床心血管结局和总死亡率之间的相关性。

研究人员通过高效液相色谱法测量了一个前瞻性队列研究中1016名参与者的7-KC水平，这些参与者为稳定型CAD患者（平均年龄63.2岁，男性占61.1%），在2008年12月至2011年12月期间招募入研究，中位随访了4.6年。研究人员通过审查病历和死亡证明来判定心肌梗死（MI）、住院心力衰竭（HF），心血管（CV）死亡、全因死亡和MI/HF/死亡的复合终点。研究人员采用多变量Cox比例风险分析比较了心血管事件和全因死亡的发生率，根据血浆7-KC水平的四分位数。

在中位随访4.6年期间，共有221名参与者（21.8%）经历了心血管事件或死亡。调整后的复合终点的风险在7-KC水平位于最高四分位数范围的患者中较高，相比于最低四分位数范围的患者（风险比为1.76；95%可信区间为1.42-2.21；P＜0.001）。对人口学和临床变量和其他生物标志物，包括C-反应蛋白（hs-CRP）和脑型钠尿肽前体N端片段（NT-proBNP），进行调整后，7-KC水平每增加一个标准差（SD）仍然与复合结局发生率升高36%相关（风险比为1.36；95%可信区间为1.22-1.48，P=0.007）。血浆中7-KC水平可以明显改善各种模型性能指标。

由此可见，7-KC水平升高与稳定型CAD患者心血管事件、总死亡和复合结局风险增加相关。

原始出处：

Jiayi Song,et al. Association of Plasma 7-Ketocholesterol with Cardiovascular Outcomes and Total Mortality in Patients with Coronary Artery Disease.Circulation research. 2017. https://doi.org/10.1161/CIRCRESAHA.117.311049

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createdAvatar=https://wx.qlogo.cn/mmopen/iaqwic5175nrs2asVmGicNahCpBSxNUbSuA4vpeiazhWPdV79iaSIJsvMiaGECEouckrnOYc6073M9RbpNPL6qU9SdfB5BsicIqON4X/0, createdBy=f47f2017208, createdName=1e20390em99(暂无匿称), createdTime=Fri Apr 07 09:19:44 CST 2017, time=2017-04-07, status=1, ipAttribution=)]
    2017-04-09 doctorJiangchao

    好文章指导临床。

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/iaqwic5175nrs2asVmGicNahCpBSxNUbSuA4vpeiazhWPdV79iaSIJsvMiaGECEouckrnOYc6073M9RbpNPL6qU9SdfB5BsicIqON4X/0, createdBy=f47f2017208, createdName=1e20390em99(暂无匿称), createdTime=Fri Apr 07 09:19:44 CST 2017, time=2017-04-07, status=1, ipAttribution=)]
    2017-04-08 小林科研

    要和控制7–kc水平，将对稳定型CAD预后帮助很大

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/iaqwic5175nrs2asVmGicNahCpBSxNUbSuA4vpeiazhWPdV79iaSIJsvMiaGECEouckrnOYc6073M9RbpNPL6qU9SdfB5BsicIqON4X/0, createdBy=f47f2017208, createdName=1e20390em99(暂无匿称), createdTime=Fri Apr 07 09:19:44 CST 2017, time=2017-04-07, status=1, ipAttribution=)]
    2017-04-08 xiaogang320

    #心血管预后#

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/iaqwic5175nrs2asVmGicNahCpBSxNUbSuA4vpeiazhWPdV79iaSIJsvMiaGECEouckrnOYc6073M9RbpNPL6qU9SdfB5BsicIqON4X/0, createdBy=f47f2017208, createdName=1e20390em99(暂无匿称), createdTime=Fri Apr 07 09:19:44 CST 2017, time=2017-04-07, status=1, ipAttribution=)]
    2017-04-08 liubm557

    #冠心病患者#

    0

  8. 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2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186061, encodeId=6c431860616f, content=要和控制7–kc水平，将对稳定型CAD预后帮助很大, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5hq7GzrreT6BIby4Nk9TuR1sMLt9C0uQP5wCdRDsQ192EafCsTwd5qTISHbU3RDATQxqtPEFME4VSX3iaDd76tx/0, createdBy=50852046917, createdName=小林科研, createdTime=Sat Apr 08 23:51:55 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508628, encodeId=4a9a15086282a, content=<a href='/topic/show?id=884c51916cd' target=_blank style='color:#2F92EE;'>#心血管预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51916, encryptionId=884c51916cd, topicName=心血管预后)], attachment=null, 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authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Apr 08 06:35:20 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185825, encodeId=9a8a1858250e, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Fri Apr 07 19:30:13 CST 2017, time=2017-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185729, encodeId=51a5185e294f, content=值得学习分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/iaqwic5175nrs2asVmGicNahCpBSxNUbSuA4vpeiazhWPdV79iaSIJsvMiaGECEouckrnOYc6073M9RbpNPL6qU9SdfB5BsicIqON4X/0, createdBy=f47f2017208, createdName=1e20390em99(暂无匿称), createdTime=Fri Apr 07 09:19:44 CST 2017, time=2017-04-07, status=1, ipAttribution=)]
    2017-04-08 1e0f8808m18(暂无匿称)

    学习了，很好的研究。

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=187784, encodeId=a2f818e78499, content=谢谢分享谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160823/IMG57BBA4F88B06B5498.jpg, createdBy=29f71719637, createdName=ffffffffff, createdTime=Sun Apr 16 00:45:34 CST 2017, time=2017-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=187525, encodeId=269e18e5258d, content=谢谢分享谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160823/IMG57BBA4F88B06B5498.jpg, createdBy=29f71719637, createdName=ffffffffff, createdTime=Sat Apr 15 04:36:06 CST 2017, time=2017-04-15, status=1, ipAttribution=), 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authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Apr 08 06:35:20 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185825, encodeId=9a8a1858250e, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Fri Apr 07 19:30:13 CST 2017, time=2017-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185729, encodeId=51a5185e294f, content=值得学习分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/iaqwic5175nrs2asVmGicNahCpBSxNUbSuA4vpeiazhWPdV79iaSIJsvMiaGECEouckrnOYc6073M9RbpNPL6qU9SdfB5BsicIqON4X/0, createdBy=f47f2017208, createdName=1e20390em99(暂无匿称), createdTime=Fri Apr 07 09:19:44 CST 2017, time=2017-04-07, status=1, ipAttribution=)]
    2017-04-07 绛珠草小姐

    学习了，谢谢

    0

  10. 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2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186061, encodeId=6c431860616f, content=要和控制7–kc水平，将对稳定型CAD预后帮助很大, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5hq7GzrreT6BIby4Nk9TuR1sMLt9C0uQP5wCdRDsQ192EafCsTwd5qTISHbU3RDATQxqtPEFME4VSX3iaDd76tx/0, createdBy=50852046917, createdName=小林科研, createdTime=Sat Apr 08 23:51:55 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508628, encodeId=4a9a15086282a, content=<a href='/topic/show?id=884c51916cd' target=_blank style='color:#2F92EE;'>#心血管预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51916, encryptionId=884c51916cd, topicName=心血管预后)], attachment=null, 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authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Apr 08 06:35:20 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185825, encodeId=9a8a1858250e, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/1A51842815047D40BFDAA8D69AA8E519/100, createdBy=fd7f2029163, createdName=绛珠草小姐, createdTime=Fri Apr 07 19:30:13 CST 2017, time=2017-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185729, encodeId=51a5185e294f, content=值得学习分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/iaqwic5175nrs2asVmGicNahCpBSxNUbSuA4vpeiazhWPdV79iaSIJsvMiaGECEouckrnOYc6073M9RbpNPL6qU9SdfB5BsicIqON4X/0, createdBy=f47f2017208, createdName=1e20390em99(暂无匿称), createdTime=Fri Apr 07 09:19:44 CST 2017, time=2017-04-07, status=1, ipAttribution=)]
    2017-04-07 1e20390em99(暂无匿称)

    值得学习分享

    0

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